윤경철 교수
Kyung Chul Yoon
서울대학교 · 의학
연구실 소개
윤경철 교수의 연구실은 눈의 건조증과 관련된 염증 반응, 면역 반응, 그리고 각막 상피 손상의 분자 기전을 중심으로 연구를 진행하고 있습니다. 특히 흐린 눈물막과 각막 표면의 손상 메커니즘을 밝히기 위해 면역세포 유도화학물질(CXCL9/10/11, IL-6, TNF-α)과 Th1/Th2 반응의 조절 메커니즘을 분석하고 있으며, 당뇨병 등 만성질환에 의한 눈의 구조적·기능적 변화를 정량적으로 평가하는 데에도 주력하고 있습니다. 이와 더불어 유전자 수정 기반의 유전자 치료 전략 개발을 통해 유전적 이상이 원인이 되는 안과 질환의 근본적 치료법 모색도 시도하고 있습니다.
연구 현황
연구 성과 추이
표시된 성과는 수집된 데이터 기준으로 산출되며, 일부 차이가 있을 수 있습니다.
주요 논문
15The indication of liver transplantation (LT) for the treatment of advanced hepatocellular carcinoma (HCC) is expanding. However, portal vein tumor thrombus (PVTT) has been still accepted as an absolute contraindication. We experienced an unexpectedly good prognosis in selected patients. Therefore, we tried to identify the prognostic factors after LT for HCC with major PVTT. Among 282 patients who underwent living donor liver transplantation (LDLT) for HCC from January 2009 to December 2013, 11 (
Treatment strategies that include liver resection offer a survival benefit compared with non-surgical treatments for potentially resectable BCLC-B HCC.
Pure laparoscopic donor right hepatectomy is both feasible and safe when performed at a center experienced in adult living donor liver transplantation. Performance of about 60 PLDRHs over 1 year is sufficient to standardize the procedure.
Hong, Suk Kyun M.D.; Lee, Kwang‐Woong M.D., Ph.D.; Kim, Hyo‐Sin M.D.; Yoon, Kyung Chul M.D.; Ahn, Sung‐Woo M.D.; Choi, Jin Yong M.D.; Kim, Hyeyoung M.D.; Yi, Nam‐Joon M.D., Ph.D.; Suh, Kyung‐Suk M.D., Ph.D. Author Information
Split-liver transplantation (SLT) should be cautiously considered because the right trisection (RTS) graft can be a marginal graft in adult recipients. Herein, we analyzed the outcomes of RTS-SLT in Korea, where >75% of adult liver transplantations are performed with living donor liver transplantation. Among 2462 patients who underwent deceased donor liver transplantations (DDLTs) from 2005 to 2014, we retrospectively reviewed 86 (3.5%) adult patients who received a RTS graft (RTS-SLT group). Th
Conventional biochemical markers have limited usefulness in the prediction of early liver dysfunction. We, therefore, tried to find more useful liver failure biomarkers after liver resection that are highly sensitive to internal and external challenges in the biological system with a focus on liver metabolites. Twenty pigs were divided into the following 3 groups: sham operation group (n = 6), 70% hepatectomy group (n = 7) as a safety margin of resection model, and 90% hepatectomy group (n = 7)
Our validated AR system has the potential to effectively enable the prediction of internal hepatic anatomic structures during 3D laparoscopic liver resection, and may enhance 3D visualization for select laparoscopic liver surgeries.
Management of chalazion, characterized by noninfectious chronic granulomatous inflammation of the meibomian glands (MGs), remains challenging in ophthalmic practice, particularly because of its propensity for recurrence even after surgical intervention. This study aimed to evaluate the combined efficacy of doxycycline and intense pulsed light (IPL) therapy for treating intractable recurrent chalazion, focusing on reducing recurrence rates and improving MG status. This retrospective study include
Lenvervimab decreases HBsAg secretion, and HBsAg antibody precipitation in the multivesicular body may play an important role.
Aims: Laparoscopic living donor hepatectomy is performed selectively in some countries because of the small sized structures and anatomic variations which requires more precise technique. In Kazakhstan about 200 cases of living donor liver transplantation were performed starting from December 2011.We now present the first case of laparoscopic living donor hepatectomy in Kazakhstan using a 3D laparoscopic device with colleagues from Seoul National University Hospital, Korea by professor KwangWoon
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