윤경확 교수

ERlow breast cancer showed distinct clinicopathological features. ERlow tumors seemed to have higher recurrence rates compared to ERhigh tumors, and they showed no significant benefit from hormonal therapy. Future large scale prospective studies are necessary to validate the treatment options for ERlow breast cancer.

While <i>BRCA1/2</i> mutation carriers had a higher risk of developing CBC compared to non-carriers at high-risk of HBOC, the risk of IBTR was similarly high across breast cancer patients irrespective of the <i>BRCA</i> mutation. Further preventive strategies to reduce CBC and IBTR for all patients at high-risk of HBOC should be investigated.

Preserving the anterior lamellar fat in NSM was associated with thicker mastectomy flap, overall lower rates of complications, including ischemia of the mastectomy flap and nipple-areolar complex, and was associated with better aesthetic outcomes and improved quality of life.

The findings suggest that plasma proteome profiling can reveal potential diagnostic biomarkers for breast cancer and may contribute to early detection and personalized treatment strategies. A further validation study with a larger sample cohort of breast cancer patients is planned.

Abstract PurposeEstrogen receptor (ER) expression in breast cancer plays an essential role in carcinogenesis and disease progression. Recently, tumors with low level (1-10%) of ER expression have been separately defined as ER Low Positive (ER low ). It is suggested that ER low tumors might be morphologically and behaviorally different from tumors with high ER expression (ER high ).MethodsRetrospective analysis of a prospective cohort database was performed. Patients who underwent curative surger

The presence of a DCIS component carries varied prognostic significance in <i>BRCA1</i> and <i>BRCA2</i> mutations. A tailored approach may be necessary when determining treatment options for breast cancer patients with <i>BRCA1/2</i> mutations based on the presence of DCIS.

Background Data on the impact of preoperative MRI on long-term outcomes in young patients with breast cancer are insufficient. Purpose To investigate the associations of preoperative MRI with recurrence and survival outcomes in patients 50 years or younger with newly diagnosed breast cancer, and the impact of hormone receptor status on these associations. Materials and Methods This retrospective study included patients aged 50 years or younger with newly diagnosed unilateral breast cancer who un

Abstract Abstract Background: Although Breast Cancer Susceptibility Gene (BRCA)-associated invasive breast cancer has been extensively studied, there are few reports on ductal carcinoma in situ (DCIS) in patients with BRCA1/2 mutations. This study aims to evaluate the prognostic effect of DCIS in breast cancer patients with pathologic variants of BRCA1/2 genes. Methods: Retrospective analysis was performed on a prospective cohort of 157 patients who were found positive for BRCA1/2 mutations thro

OPS is widely practiced among Korean breast surgeons, with the increasing adoption of advanced techniques such as robotic-assisted and endoscopic surgery. Although preferences differ with the surgeon's age, the concept of OPS has expanded considerably, and a multidisciplinary approach remains critical. Understanding these trends is essential to optimize patient care and improve surgical training programs.