이동현 교수
Lee, Donghyeon
서울대학교 내과학교실 · 의학
연구실 소개
이동현 교수 연구실은 심혈관 질환, 간질환, 암 등 만성질환의 생물학적 기전과 예후 생물학적 마커를 규명하는 데 초점을 맞추고 있습니다. 특히 고혈압 환자에서의 수축기 혈압 조절, 간경변 환자에서의 세균성 복막염 예후 평가, 블라더 퇄세포암에서의 텔로머라제 활성과 관련된 진단 생물학적 지표 탐색을 주요 연구 방향으로 삼고 있습니다. 또한, 신경망 기반 영상 강화 기술을 활용한 의료 영상 분석 기법 개발을 통해 정밀의료의 기반을 마련하고자 합니다.
연구 현황
연구 성과 추이
표시된 성과는 수집된 데이터 기준으로 산출되며, 일부 차이가 있을 수 있습니다.
주요 논문
15Telomerase is an enzyme that immortalizes cells by maintaining a constant telomere length. Here, telomerase activity in bladder washes was analyzed and compared with the final pathological diagnosis in 23 patients with bladder transitional cell carcinoma (TCC). Bladder washes and normal tissues were obtained from each patient prior to transurethral resection of bladder tumor. Telomerase activity was detected using telomeric repeat amplification protocol assay based on PCR. Cytological diagnosis
No significant association was identified between polymorphisms near the IL28B gene and the natural courses of chronic HBV infection, including the HBV clearance and HCC occurrence.
CFR can be a comprehensive indicator of cardiovascular risk factors, including parameters of the FRSS, in subjects with chest pain and a normal coronary angiogram.
Generative adversarial networks (GANs) are used for image enhancement such as single image super-resolution (SISR) and deblurring. The conventional GANs-based image enhancement suffers from two drawbacks that cause a quality degradation due to a loss of detailed information. First, the conventional discriminator network adopts strided convolution layers which cause a reduction in the resolution of the feature map, and thereby resulting in a loss of detailed information. Second, the previous GANs
Age is an independent risk factor for EMBPS in patients with never-treated hypertension. BP control in the early morning period is more important in elderly patients so as to prevent cardiovascular events.
This study found that serum hs-CRP level is related to a lower response rate to antibiotics, a higher mortality rate in patients with SBP. The hs-CRP level was negatively correlated with the CP and Model for End-Stage Liver Disease scores, which suggests that the prognostic function of hs-CRP was not a surrogate for hepatic dysfunction.
We evaluated the efficacy and safety of Ecklonia cava polyphenol (Seapolynol™, a polyphenol antioxidant and anti-inflammatory agent purified from E. cava) during a 12-week treatment period (400 mg orally once daily) in individuals with hypercholesterolemia and performed subgroup analysis for metabolic syndrome (MetS). As a noncomparative study, forty-six individuals (M:F=22:24, mean age=54±11 years) with fasting total cholesterol concentration >240 mg/dL or low-density lipoprotein cholesterol (L
We present a method to synthesize stable and uniform high-quality perovskite nanocrystals (PNCs) by using excess halide to recover surface defects in CsPbBr3/ZnS core/shell nanocrystals. Use of N-bromosuccinimide as a halide donor recovered surface halide vacancies of bare CsPbBr3 PNCs during the growth of the ZnS shell, as confirmed by DFT calculations. This approach achieves a high photoluminescence quantum yield of nearly 1, and significantly increases the stability of PNCs under adverse cond
The questionnaire-based diagnosis of current asthma is associated with API, but not with spirometry, AHR, FeNO, or atopic sensitization in preschool children.
The VPA-induced increase in NKG2D ligands expression significantly enhanced the effects of CIK cell therapy in a mouse model of HCC.
Patients with CHB have an elevated risk of developing primary extrahepatic malignancy. Long-term NA treatment was associated with a lower risk of extrahepatic malignancy development among patients with CHB.
The IGF-CTP classification was slightly better than the original CTP classification for predicting survival of patients with HCC in a chronic hepatitis B endemic area. This is most likely due to the fact that serum IGF-1 levels reflect underlying HCC status.
Increased IMA after EST suggests a large ischemic burden in coronary artery disease, so the DeltaIMA during EST may be useful for predicting the severity of myocardial ischemia.
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