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이동현 교수

Lee, Donghyeon

서울대학교 내과학교실 · 의학

연구실 소개

이동현 교수 연구실은 심혈관 질환, 간질환, 암 등 만성질환의 생물학적 기전과 예후 생물학적 마커를 규명하는 데 초점을 맞추고 있습니다. 특히 고혈압 환자에서의 수축기 혈압 조절, 간경변 환자에서의 세균성 복막염 예후 평가, 블라더 퇄세포암에서의 텔로머라제 활성과 관련된 진단 생물학적 지표 탐색을 주요 연구 방향으로 삼고 있습니다. 또한, 신경망 기반 영상 강화 기술을 활용한 의료 영상 분석 기법 개발을 통해 정밀의료의 기반을 마련하고자 합니다.

심혈관 위험생물학적 마커텔로머라제의료 영상 강화예후 평가

연구 현황

논문 수
409
총 인용 수
6,230
최근 5년 논문
79
주요 분야
의학

연구 성과 추이

표시된 성과는 수집된 데이터 기준으로 산출되며, 일부 차이가 있을 수 있습니다.

5개년 연도별 논문 게재 수
79총합
2022
2023
2024
2025
2026
5개년 연도별 피인용 수
1,028총합
20222023202420252026

주요 논문

15
1
논문|인용수 64·1998
Telomerase: a potential marker of bladder transitional cell carcinoma in bladder washes.
Dong Hyeon Lee, Seung Choul Yang, Sung Joon Hong, Byung Ha Chung, Isaac Yi Kim
FWCI 3.2PubMed

Telomerase is an enzyme that immortalizes cells by maintaining a constant telomere length. Here, telomerase activity in bladder washes was analyzed and compared with the final pathological diagnosis in 23 patients with bladder transitional cell carcinoma (TCC). Bladder washes and normal tissues were obtained from each patient prior to transurethral resection of bladder tumor. Telomerase activity was detected using telomeric repeat amplification protocol assay based on PCR. Cytological diagnosis

PhysiologyMedicine
2
논문|인용수 30·2013
Polymorphisms near <b><i>Interleukin 28B</i></b> Gene Are Not Associated with Hepatitis B Virus Clearance, Hepatitis B e Antigen Clearance and Hepatocellular Carcinoma Occurrence
Dong Hyeon Lee, Yuri Cho, Ji Yeon Seo, Jung Hee Kwon, Eun Ju Cho, Eun Sun Jang, Min‐Sun Kwak, Jae Youn Cheong, Sung Won Cho, Jeong‐Hoon Lee, Su Jong Yu, Jung‐Hwan Yoon
SJR Q3FWCI 4.1IntervirologyOA

No significant association was identified between polymorphisms near the IL28B gene and the natural courses of chronic HBV infection, including the HBV clearance and HCC occurrence.

EpidemiologyMedicine
3
논문|인용수 30·2010
Coronary Flow Reserve Is a Comprehensive Indicator of Cardiovascular Risk Factors in Subjects With Chest Pain and Normal Coronary Angiogram
Dong Hyeon Lee, Ho‐Joong Youn, Yun‐Seok Choi, Chul‐Soo Park, Jeong Hwan Park, Hui‐Kyung Jeon, Eung Ju Kim
SJR Q1FWCI 2.0Circulation JournalOA

CFR can be a comprehensive indicator of cardiovascular risk factors, including parameters of the FRSS, in subjects with chest pain and a normal coronary angiogram.

Radiology, Nuclear Medicine and ImagingMedicine
4
논문|인용수 29·2019
Resolution-Preserving Generative Adversarial Networks for Image Enhancement
Donghyeon Lee, Sangheon Lee, Lee Hoseong, Kyujoong Lee, Hyuk‐Jae Lee
SJR Q1FWCI 1.8IEEE AccessOA

Generative adversarial networks (GANs) are used for image enhancement such as single image super-resolution (SISR) and deblurring. The conventional GANs-based image enhancement suffers from two drawbacks that cause a quality degradation due to a loss of detailed information. First, the conventional discriminator network adopts strided convolution layers which cause a reduction in the resolution of the feature map, and thereby resulting in a loss of detailed information. Second, the previous GANs

Computer Vision and Pattern RecognitionComputer Science
5
논문|인용수 26·2009
Age is an Independent Risk Factor for the Early Morning Blood Pressure Surge in Patients Never-Treated for Hypertension
Dong Hyeon Lee, Sang‐Hyun Ihm, Ho‐Joong Youn, Yun‐Seok Choi, Chanseok Park, Chul‐Soo Park, Jong Min Lee, Heeyoul Kim, Yong‐Seog Oh, Wook-Sung Chung, Ki‐Bae Seung, Eung Ju Kim
SJR Q2FWCI 0.7Korean Circulation JournalOA

Age is an independent risk factor for EMBPS in patients with never-treated hypertension. BP control in the early morning period is more important in elderly patients so as to prevent cardiovascular events.

Cardiology and Cardiovascular MedicineMedicine
6
논문|인용수 25·2013
High-sensitivity C-reactive Protein Level is an Independent Predictor of Poor Prognosis in Cirrhotic Patients With Spontaneous Bacterial Peritonitis
Yuri Cho, So Youn Park, Jeong‐Hoon Lee, Dong Hyeon Lee, Minjong Lee, Jeong‐Ju Yoo, Won‐Mook Choi, Young Youn Cho, Yun Bin Lee, Jae Woong Yoon, Jung Hee Kwon, Eun Ju Cho
SJR Q2FWCI 1.1Journal of Clinical Gastroenterology

This study found that serum hs-CRP level is related to a lower response rate to antibiotics, a higher mortality rate in patients with SBP. The hs-CRP level was negatively correlated with the CP and Model for End-Stage Liver Disease scores, which suggests that the prognostic function of hs-CRP was not a surrogate for hepatic dysfunction.

HepatologyMedicine
7
논문|인용수 23·2024
Enhancing reliability in oxide-based memristors using two-dimensional transition metal dichalcogenides
Donghyeon Lee, Seung Mo Kim, Jun-Cheol Park, Yoonsung Jung, Soyeon Lee, Byoung Hun Lee, Sanghan Lee, Sanghan Lee, Sanghan Lee
SJR Q1FWCI 4.8Applied Surface Science
Electrical and Electronic EngineeringEngineering
8
논문|인용수 22·2012
Effects of <i>Ecklonia cava</i> Polyphenol in Individuals with Hypercholesterolemia: A Pilot Study
Dong Hyeon Lee, Mi Yeon Park, Byung Joo Shim, Ho‐Joong Youn, Hye Jeong Hwang, Hyeon‐Cheol Shin, Hui Kyung Jeon
SJR Q3FWCI 1.7Journal of Medicinal Food

We evaluated the efficacy and safety of Ecklonia cava polyphenol (Seapolynol™, a polyphenol antioxidant and anti-inflammatory agent purified from E. cava) during a 12-week treatment period (400 mg orally once daily) in individuals with hypercholesterolemia and performed subgroup analysis for metabolic syndrome (MetS). As a noncomparative study, forty-six individuals (M:F=22:24, mean age=54±11 years) with fasting total cholesterol concentration >240 mg/dL or low-density lipoprotein cholesterol (L

Aquatic ScienceAgricultural and Biological Sciences
9
논문|인용수 18·2024
Surface Defect Recovery in Perovskite Nanocrystals with Excess Halide for Core–Shell Structure
Dong Hyeon Lee, Woo Hyeon Jeong, Seokhyun Choung, Ji Won Jang, Gyudong Lee, Hochan Song, Sang‐Hun Han, Gyeong Eun Seok, Ji-Hoon Kim, Myeonggeun Han, Jeong Woo Han, Hyosung Choi
SJR Q1FWCI 3.8ACS Energy Letters

We present a method to synthesize stable and uniform high-quality perovskite nanocrystals (PNCs) by using excess halide to recover surface defects in CsPbBr3/ZnS core/shell nanocrystals. Use of N-bromosuccinimide as a halide donor recovered surface halide vacancies of bare CsPbBr3 PNCs during the growth of the ZnS shell, as confirmed by DFT calculations. This approach achieves a high photoluminescence quantum yield of nearly 1, and significantly increases the stability of PNCs under adverse cond

Electrical and Electronic EngineeringEngineering
10
논문|인용수 17·2019
Asthma predictive index as a useful diagnostic tool in preschool children: a cross-sectional study in Korea
Dong Hyeon Lee, Ji‐Won Kwon, Hyung Young Kim, Ju‐Hee Seo, Hyo-Bin Kim, So Yeon Lee, Gwang-Cheon Jang, Dae Jin Song, Woo Kyung Kim, Young-Ho Jung, Soo‐Jong Hong, Jung Yeon Shim
SJR Q1FWCI 0.9Clinical and Experimental PediatricsOA

The questionnaire-based diagnosis of current asthma is associated with API, but not with spirometry, AHR, FeNO, or atopic sensitization in preschool children.

PhysiologyMedicine
11
논문|인용수 15·2019
Catalytic cyclohexene oxidation in the nano channels of a copper silicate material
Dong Hyeon Lee, Hyun Sung Kim
SJR Q2FWCI 0.8Applied Catalysis A General
Materials ChemistryMaterials Science
12
논문|인용수 15·2017
Synergistic effect of cytokine-induced killer cell with valproate inhibits growth of hepatocellular carcinoma cell in a mouse model
Dong Hyeon Lee, Joon Yeul Nam, Young Woon Chang, Hyeki Cho, Seong Hee Kang, Young Youn Cho, Eun Ju Cho, Jeong‐Hoon Lee, Su Jong Yu, Yoon Jun Kim, Jung‐Hwan Yoon
SJR Q1FWCI 1.2Cancer Biology & TherapyOA

The VPA-induced increase in NKG2D ligands expression significantly enhanced the effects of CIK cell therapy in a mouse model of HCC.

ImmunologyImmunology and Microbiology
13
논문|인용수 15·2022
Association of Chronic Hepatitis B Infection and Antiviral Treatment With the Development of the Extrahepatic Malignancies: A Nationwide Cohort Study
Dong Hyeon Lee, Sung Won Chung, Jeong‐Hoon Lee, Hwi Young Kim, Goh Eun Chung, Mi‐Sook Kim, Bo Ram Yang, Joon Yeul Nam, Yun Bin Lee, Yoon Jun Kim, Jung‐Hwan Yoon
SJR Q1FWCI 2.2Journal of Clinical Oncology

Patients with CHB have an elevated risk of developing primary extrahepatic malignancy. Long-term NA treatment was associated with a lower risk of extrahepatic malignancy development among patients with CHB.

EpidemiologyMedicine
14
논문|인용수 14·2017
Validation of a Modified Child-Turcotte-Pugh Classification System Utilizing Insulin-Like Growth Factor-1 for Patients with Hepatocellular Carcinoma in an HBV Endemic Area
Dong Hyeon Lee, Jeong‐Hoon Lee, Yong Jin Jung, Jungsoo Gim, Won Kim, Byeong Gwan Kim, Kook Lae Lee, Yuri Cho, Jeong‐Ju Yoo, Minjong Lee, Young Youn Cho, Eun Ju Cho
SJR Q1FWCI 1.0PLoS ONEOA

The IGF-CTP classification was slightly better than the original CTP classification for predicting survival of patients with HCC in a chronic hepatitis B endemic area. This is most likely due to the fact that serum IGF-1 levels reflect underlying HCC status.

EpidemiologyMedicine
15
논문|인용수 14·2010
Change in Ischemia-Modified Albumin and Its Clinical Significance During Exercise Stress Testing
Dong Hyeon Lee, Hui-Kyung Jeon, Hun‐Jun Park, Woo‐Seung Shin, Seungwon Lee, Ho‐Joong Youn, Chul-Min Kim, Hae Kyung Lee
SJR Q1FWCI 7.1Circulation JournalOA

Increased IMA after EST suggests a large ischemic burden in coronary artery disease, so the DeltaIMA during EST may be useful for predicting the severity of myocardial ischemia.

Complementary and alternative medicineMedicine

대표 연구 분야

EpidemiologyAerospace EngineeringHepatologyMolecular BiologyPulmonary and Respiratory MedicineCivil and Structural Engineering

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