이정수 교수
Lee Jungsoo
서울대학교 · 공학
연구실 소개
이 교수의 연구실은 신경생물학과 나노소재를 융합한 다학제적 연구를 선도하고 있습니다. 주로 척추동물의 뇌신경계 형성과 축삭 유도 메커니즘을 규명하기 위해 제브라피시를 모델 생물로 활용하며, 뇌의 구조적 발달과 신경 회로 형성에 관여하는 Robo 수용체 유전자들의 기능을 분석하고 있습니다. 또한 반도체 나노소재를 활용한 생체센서 및 광검출기 기술 개발을 통해 신경질환 치료와 연계된 정밀의료 기반 기술을 개발하고 있습니다.
연구 현황
연구 성과 추이
표시된 성과는 수집된 데이터 기준으로 산출되며, 일부 차이가 있을 수 있습니다.
주요 논문
15We report the cloning and expression patterns of three novel zebrafish Roundabout homologs. The Roundabout (robo) gene encodes a transmembrane receptor that is essential for axon guidance in Drosophila and Robo family members have been implicated in cell migration. Analysis of extracellular domains and conserved cytoplasmic motifs shows that zebrafish Robo1 and Robo2 are orthologs of mammalian Robo1 and Robo2, respectively, while zebrafish Robo3 is likely to be an ortholog of mouse Rig-1. The th
We have fabricated Si nanowire (SiNW) based ion-sensitive field effect transistors (ISFETs) for biosensing applications. The ability to prepare a large number of sensors on a wafer, the use of standard silicon microfabrication techniques resulting in cost savings, and potential high sensitivity are significant advantages in favor of nanoscale SiNW ISFETs. The SiNW ISFETs with embedded Ag/AgCl reference electrode were fabricated on a standard silicon-on-insulator wafer using electron-beam lithogr
The electronic and photoconductive characteristics of CdTe nanowire-based field effect transistors were studied systematically. The electrical characterization of a single CdTe nanowire FET verifies p-type behavior. The CdTe NW FETs respond to visible-near infrared (400–800 nm) incident light with a fast, reversible and stable response characterized by a high responsivity (81 A W−1), photoconductive gain (∼2.5 × 104%) and reasonable response and decay times (0.7 s and 1 s, respectively). These r
Image classification models tend to make decisions based on peripheral attributes of data items that have strong correlation with a target variable (i.e., dataset bias). These biased models suffer from the poor generalization capability when evaluated on unbiased datasets. Existing approaches for debiasing often identify and emphasize those samples with no such correlation (i.e., bias-conflicting) without defining the bias type in advance. However, such bias-conflicting samples are significantly
This study was supported by the National Research Foundation of Korea (NRF) grant funded by the Korea government (Ministry of Science and ICT; No. NRF-2017R1A2B4009568), grants of the Korean Health Technology R&D Project, Ministry for Health, Welfare & Family Affairs, and the Republic of Korea (HI13C0010, HI14C1324, HI14C1799).
Noninvasive brain stimulation (NBS), such as repetitive transcranial magnetic stimulation (rTMS) or transcranial direct current stimulation (tDCS), has been used in stroke patients with motor impairment. NBS can help recovery from brain damage by modulating cortical excitability. However, the efficacy of NBS varies among individuals. To obtain insights of responsiveness to the efficacy of NBS, we investigated characteristic changes of the motor network in responders and nonresponders of NBS over
We report on the characterization of low-frequency noise in fully depleted (FD) double-gate p-channel FinFETs. While the average noise follows a 1/f dependence, considerable device-to-device variations in noise level are observed due to the statistical fluctuation of the number of oxide traps involved. We found that the low-frequency noise in poly-Si-gated p-FinFETs is mainly governed by the carrier number fluctuation with correlated mobility fluctuation. The low-frequency noise characteristics
Electroencephalography (EEG) is electrical brain activity that can be measured on the scalp with Ag/AgCl electrodes and conductive gel. However, time‐consuming preparation procedures, dehydration of the gel, and skin irritation are crucial drawbacks of using such electrodes. Alternative approaches involving the use of spiky dry electrodes have their own drawbacks such as limited skin–electrode contact area, high skin–electrode impedance, and pain. Reverse‐curve‐arch‐shaped dry EEG electrodes for
Most previous stroke studies have been performed in heterogeneous patient populations. Moreover, the brain network might demonstrate different recovery dynamics according to lesion location. In this study, we investigated variation in motor network alterations according to lesion location. Forty patients with subcortical ischemic stroke were enrolled. Patients were divided into two groups: 21 patients with supratentorial stroke (STS) and 19 patients with infratentorial stroke (ITS). All patients
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