김미경 교수

Gastrointestinal stromal tumors (GIST) occur primarily in the wall of the intestine and are characterized by activating mutations in the receptor tyrosine kinases genes KIT or PDGFRA. The diagnosis of GIST relies heavily on the demonstration of KIT/CD117 protein expression by immunohistochemistry. However, KIT expression is absent in approximately 4% to 15% of GIST and this can complicate the diagnosis of GIST in patients who may benefit from treatment with receptor tyrosine kinase inhibitors. W

DM is a significant risk factor for COVID-19 severity and mortality. Our findings imply that COVID-19 patients with DM, especially if elderly, require special attention and prompt intensive care.

The SRC kinase family comprises non-receptor tyrosine kinases that are ubiquitously expressed in all cell types. Although Src is reportedly activated in pulmonary and renal fibrosis, little is known regarding its role in liver fibrosis. This study investigated whether the inhibition of Src protects against liver fibrosis. The expression of Src was upregulated in thioacetamide (TAA)-induced fibrotic mouse liver and cirrhosis of patients, and phospho-Src was upregulated during activation of hepati

The results of our systematic review and meta-analysis suggest that there is limited evidence for CAT being superior to IAT in the treatment of cerebral infarction. The total number of RCTs included in our analysis was low, however, and the RCTs included had a high risk of bias. Future RCTs appear to be warranted.

Diabetic kidney disease (DKD) is a leading cause of end-stage renal disease in Korea and worldwide, and is a risk factor for the development of cardiovascular complications. The conventional treatments for DKD are control of blood glucose and blood pressure levels by inhibiting the renin-angiotensin system. However, the prevalence of DKD continues to increase and additional therapies are required to prevent or ameliorate the condition. Many drugs have been, or are being, developed to target the

연구목적: 본 연구의 목적은 경로분석을 통해 일반간호사의 직무스트레스 요인과 환자안전문화 인식 및 환자안전간호 활동 간의 인과관계를 탐색하는 것이다. 연구방법: 서울소재 대학병원에서 근무하는 경력 1년 이상 일반간호사 275명을 대상으로 2018년 1월 5일부터 2월 28일까지 설문지를 사용하여 자료 수집하였다. 자료 분석은 SPSS 프로그램(ver. 24)을 이용하여 기술적 통계, t-test, ANOVA, Scheffé test 및 Pearson correlation coefficients를 분석하였고 AMOS 프로그램(ver. 24)을 이용하여 경로분석과 부트스트래핑 방법을 사용하였다. 연구결과: 가설모형을 경로 분석한 결과 각 내생변수에 상당한 설명력을 보였고, 조직문화는 업무량 과중, 전문적 지식과 기술부족, 부적절한 보상, 근무환경 및 의사소통에 의해 45%가 설명되었다. 연구결과 환자안전문화 인식이 직무스트레스 요인과 환자안전간호 활동 간의 매개효과가 있음을 확인하였다.

Clusterin is a glycoprotein that is expressed in most human tissues and found in body fluids. In our previous studies we demonstrated that clusterin has a protective effect against hepatic lipid accumulation and renal fibrosis; however, the role of clusterin in hepatic fibrosis is unknown. Here, we examined whether clusterin had protective effects against hepatic fibrosis using in vitro and in vivo models. Clusterin was upregulated in the livers of human cirrhotic patients and in thioacetamide (

The reviewed studies suggested that SHP could be a major target for therapeutic intervention in metabolic and fibrotic diseases, including metabolic syndrome and its complications. However, for SHP-targeted therapy, there are some outstanding issues, including the small number of known inducers of SHP and the lack of sufficient data in humans.

Kahweol is a diterpene found in coffee beans and unfiltered coffee drinks. Several studies have demonstrated that kahweol induces the nuclear factor erythroid-2 related factor 2/ hemeoxygenase-1 (Nrf2/HO-1) pathway; however, the mechanisms involved are currently unknown. Kelch-like ECH-associated protein 1 (Keap1) is a major regulator of Nrf2 expression and is degraded mostly by autophagy. The p62 protein enhances binding to Keap1 and contributes to the activation of Nrf2. Here, we examined the

The blockade of angiotensin II (Ang II) is a major therapeutic strategy for diabetic nephropathy. The main roles of Ang II in renal disease are mediated via the Ang type 1 receptor (AT1R). Upregulation of clusterin/apolipoprotein J has been reported in nephropathy models, suggesting it has a protective role in nephropathogenesis. Here, we studied how clusterin acts against Ang II-induced renal fibrosis. Levels of AT1R and fibrotic markers in clusterin-/- mice and Ang II infused rats transfected

The objective of this study was to explore the causal relationships among staff nurses' job stress factors, patient safety culture perception, and patient safety nursing activities through path analysis. Methods: The participants, 275 staff nurses with over a year of experience working at a university hospital in Seoul, completed structured questionnaires. The data were collected from January 5 to February 28, 2018. The data analysis included descriptive statistics, t-test, ANOVA, Scheffe test a

We observed the algal species compositions and the marine algal flora in the Islands of Ullungdo and Dokdo in May, June, August and November, 1999. The total number of marine algal species was 56 species composed of the brown algae of 22 species, the red algae of 28 species and the green algae of 6 species. Among them, 53 species Here recognized in Ullungdo and 24 species in Dokdo. The sudden decrease of the algal species was distinguished as comparing with the results of the previous research.

This paper explores students’ and teacher’s experiences with project-oriented learning, as a form of critical pedagogy for Korean English language...