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The KBASE cohort is a prospective, longitudinal cohort study that recruited participants with a wide age range and a wide distribution of cognitive status (CN, MCI, and ADD) and it has several strengths in its design and methodologies. Details of the recruitment, study methodology, and baseline sample characteristics are described in this paper.

We aimed to identify and characterize subtypes of Alzheimer's disease (AD) exhibiting different patterns of regional brain atrophy on MRI using age- and gender-specific norms of regional brain volumes. AD subjects included in the Alzheimer's Disease Neuroimaging Initiative study were classified into subtypes based on standardized values (Z-scores) of hippocampal and regional cortical volumes on MRI with reference to age- and gender-specific norms obtained from 222 cognitively normal (CN) subject

The findings of this study showing both functional as well as structural changes of retina measured by multifocal electroretinogram and SS-OCT in preclinical AD suggest the potential use of retinal biomarkers as a tool for early detection of in vivo AD pathologic abnormalities in CN older adults.

Our results demonstrate that increased thalamic Ins level is associated with prodromal depressive symptoms. Further longitudinal follow-up studies with larger UHR sample sizes are required to investigate the function of Ins concentrations as a biomarker of vulnerability to psychosis.

The present findings suggest that amyloid-independent regional neurodegeneration might underlie relations of neuroticism and conscientiousness with AD.

Objective: Recent neuroimaging studies have suggested that brain changes occur in subjects at ultra-high risk (UHR) for psychosis while experiencing prodromal symptoms, among which depression may increase the risk of developing a psychotic disorder. The goal of this study is to examine brain metabolite levels in the anterior cingulate cortex, the left dorsolateral prefrontal cortex and the left thalamus in subjects at UHR for psychosis and to compare brain metabolite levels between the UHR subje

Our finding suggests that basal fasting blood insulin may have association with neuronal and synaptic activity in specific cerebral regions, particularly in the hippocampal/parahippocampal and inferior parietal regions.

Previous literature suggests that Alzheimer's disease (AD) process may contribute to late-life onset depression (LLOD). Therefore, we investigated the association of LLOD with cerebral amyloidosis and neuronal injury, the two key brain changes in AD, along with vascular risks. Twenty nine non-demented individuals who first experienced major depressive disorder (MDD) after age of 60 years were included as LLOD subjects, and 27 non-demented elderly individuals without lifetime experience of MDD we

Figure copy and recall tasks from the Benton Visual Retention Test (BVRT) and the Consortium to Establish a Registry of Alzheimer's Disease (CERAD) neuropsychological battery are used widely to assess visuospatial function in cognitively impaired (CI) individuals. We aimed to identify functional neural correlates of figure copy and recall task performances as measured by the BVRT and the CERAD constructional praxis (CP) and CP recall (CR) in CI individuals. Both tasks were administered to 64 CI

Our findings suggest that Aβ deposition may affect the central auditory pathway even before cognitive decline appears. DDT1, which can easily be applied to the old-age population, may have the potential as a screening tool for preclinical AD.

Our findings suggest that AHM use may be associated with lower Aβ burden in older adults with hypertension. Further studies exploring the underlying mechanism, particularly related to RASi, may provide insights into new therapeutic targets for AD. ANN NEUROL 2025;97:1051-1061.

Abstract Background Telomere length (TL) is known to be associated with aging and various age‐related diseases. However, previous studies on the relationship between the TL and Alzheimer’s disease (AD) yielded inconsistent results, and the association between TL and in vivo AD pathologies such as cerebral beta‐amyloid (Aβ) and tau deposition remains unclear. We investigated whether TL is related to in vivo AD pathologies and predicts future cognitive decline. Method Total 132 older adults recrui

Several studies revealed the heterogeneities of Alzheimer's disease (AD) regarding the regional distribution pattern of brain atrophy and tau pathology. However, limited information is available for heterogeneities in the regional pattern of cerebral amyloid deposition in individuals with AD. We tried to identify subtypes of regional amyloid deposition in amyloid-positive cognitively impaired (CI) individuals. Total 121 amyloid-positive CI individuals consisting of mild cognitive impairment and