김남희 교수

Objectives: The purpose of this study was to evaluate the relationship between perceived oral symptoms(POS) and perceived oral health(POH) status among the elderly in Seoul. Methods: All 443 subjects aged 60 or more in 6 welfare institutions selected using cluster sampling were surveyed cross-sectionally the self-reporting questionnaire. All 443 subjects provided written informed consents of the Seoul National University Dental Hospital Institutional Review Boards. The questionnaires consisted

We recently reported that brefeldin A-inhibited guanine nucleotide-exchange protein 3 (BIG3) binds Prohibitin 2 (PHB2) in cytoplasm, thereby causing a loss of function of the PHB2 tumor suppressor in the nuclei of breast cancer cells. However, little is known regarding the mechanism by which BIG3 inhibits the nuclear translocation of PHB2 into breast cancer cells. Here, we report that BIG3 blocks the estrogen (E2)-dependent nuclear import of PHB2 via the karyopherin alpha (KPNA) family in breast

The antibody titer of the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) was observed in 289 healthy healthcare workers who had completed the second dose of the Pfizer-BioNTech coronavirus disease 2019 (COVID-19) vaccine. Antibody tests were performed using both the automated electrochemiluminescence immunoassay (ECLIA) and the chromatographic lateral flow immunoassay (LFIA). All subjects had antibodies against the receptor binding domain of the spike protein of SARS-CoV-2 only one

Several studies reported that severe acute respiratory syndrome coronavirus-2 antibody levels change over 6 months in participants receiving the vaccination. From the enrolled 272 health care workers (HCWs), blood samples were obtained at 2, 16, and 24 weeks after the second vaccination dose. In the 267 noninfected HCWs, the neutralizing antibodies decreased by 23.9%, and the anti-spike/receptor binding domain antibody decreased by 53.8% at 24 weeks. We observed no significant difference in anti

High-risk human papillomavirus (HPV) infection is an essential factor for the development of cervical cancer. HPV18 is the second most common carcinogenic HPV type following HPV16, but the lineages of HPV18 have been less well studied than those of HPV 16. The purpose of this study was to analyze the nucleotide variants in the E6, E7, and L1 genes of HPV18, to assess the prevalence of HPV18 variants in Korea and to explore the relationship between HPV18 genetic variants and the risk for cervical

This study demonstrated that contact system activation and abundant NET formation occurred in the high thrombin generation state in hyperthyroidism and were correlated with free T4 level.

목 적 : 소아 요로감염증의 원인균을 조사하고 그 중 대부분을 차지하는 Escherichia coli에서의 extended spectrum β- lactamase(ESBL) 생성균의 빈도와 ESBL 생성 E. coli에 의한 요로감염의 위험인자를 알아보고자 하였다.방 법 : 2002년 7월부터 12월까지 6개월간 서울대학교 어린이병원에서 요로감염증으로 진단된 125례(환자수 112명)를 대상으로 하였다. 그 중 E. coli에 의한 요로감염 74례의 의무기록을 후향적으로 분석하고, ESBL 생성 여부를 National Committee for Clinical Laboratory Standards에 따른 disk 확산법과 double disk synergy test를 통해 확인하였다.결 과 : 125례의 요로감염증에서 E. coli가 74균주, Enterobacter spp.가 9균주, Klebsillea spp.가 8균주, Pseudomonas가 6균주, 그람 양성균주가 15균주 분

These results emphasize the importance of storage temperature and media or buffer and performing RT-qPCR for SARS-CoV-2 nucleic acid detection as soon as possible after sample collection.

A revised WHO classification of hematopoietic neoplasm introduced the new category 'Myeloid Neoplasms with Germline Predisposition', reflecting the growing importance of genetic testing for myeloid neoplasms. Here, we investigated monozygotic twins with the same de novo mutation in GATA2 but different phenotypes. The patient suffering a bleeding tendency was diagnosed with myelodysplastic syndrome (MDS), and her monozygotic twin showed dysmegakaryopoietic features in the bone marrow. Targeted se

WGS may play a pivotal role in TB diagnosis and the detection of drug resistance, genetic diversity, and transmission dynamics in the near future because of its accuracy, speed, and extensibility.

교량 본연의 기능과 구조물의 안전을 추구하는 기존의 공학적 교량설계에서 공학과 예술이 접목된 미학적 설계로 옮겨가기 위해서는 교량의 역사속에서 미학적 개념을 발견하고 이를 발전시켜나가는 것이 중요하다. 본 연구에서는 교량 미학의 뿌리를 찾고자 고대 교량들의 구조물 설계에 반영된 고대 건축술과 미학적 개념을 고찰하고, 이를 통해서 교량미를 새롭게 정의하고 이에 걸맞은 미학적 설계방법을 제시하였다. 제시된 미학적 개념들은 기존 교량구조물의 미학적 이해와 새로운 교량설계에 대한 미학적 설계법으로 사용될 수 있으리라 기대된다. 더 나아가서 교량설계와 건축물설계 양자간의 발전을 위해서 요구되는 통시적인 고찰의 기회를 마련해 주는데 의의가 있다.