송상훈 교수
Sang Hoon Song
서울대학교 · 의학
연구실 소개
송상훈 교수의 연구실은 주로 성기능 장애와 감염성 질환의 생물학적 기전을 규명하고자 하며, 특히 성기능저하증, 조루 및 난임 관련 질환의 메커니즘과 치료 전략을 중심으로 연구를 진행하고 있습니다. 항결핵치료제의 약물 농도 모니터링 및 개인 맞춤형 용량 조절 기술 개발을 통해 치료 효과를 극대화하고, 전통 발효제품인 누룩의 미생물 군집 분석을 통해 건강 기능성 물질의 발견에도 기여하고 있습니다. 특히, 신경 손상 이후 발기부전이 발생하는 분자 기전을 다각도로 분석함으로써 새로운 치료 타겟을 제시하고 있습니다.
연구 현황
연구 성과 추이
표시된 성과는 수집된 데이터 기준으로 산출되며, 일부 차이가 있을 수 있습니다.
주요 논문
15The prevalence of FSD in Korean young women was common and comparable to those reported worldwide.
Monitoring of anti-tuberculosis drug concentrations and dose adjustment can be helpful in cases that show poor response to treatment. Here, we describe a method that can rapidly and simultaneously measure the blood concentrations of four anti-tuberculosis drugs (isoniazid, rifampicin, pyrazinamide, and ethambutol) and two major metabolic ratios (acetylisoniazid/isoniazid and 25-desacetylrifampicin/rifampicin) using high-performance liquid chromatography/tandem mass spectrometry (HPLC/MS/MS). A C
A variety of nuruk were collected from various provinces in Korea, and their microflora profiles were analyzed at the species level. A total of 42 nuruk samples were collected and when the viable cell numbers in these nuruk were enumerated, the average cell numbers of bacteria, fungi, yeast, and lactic acid bacteria from all nuruk were 7.21, 7.91, 3.49, and 4.88 log CFU/10 g, respectively. There were no significant differences in viable cell numbers of bacteria or fungi according to regions coll
Staphylococcus pettenkoferi is a recently isolated human pathogen with only a few reported cases of infection. We report a case of bloodstream infection caused by S. pettenkoferi in a patient with pulmonary tuberculosis.
The layered perovskite compounds NaLnTiO4 (Ln = Y, La–Tb) have Ln2O2 rock-salt layers alternating with Na2O2 rock-salt layers on either side of a TiO2 sheet. The cation ordering introduces an internal electric field perpendicular to the layers. Ion exchange of Li+ for Na+ changes the rock-salt Na2O2 layers into OLi2O antifluorite layers but does not change the charge of the layers or, significantly, the internal electric field. The internal fields induce a ferroic displacement of the Ti(IV) ions
Sera from patients with TB had higher alpha-1-antitrypsin levels than sera from control participants. Alpha-1-antitrypsin levels may aid in the diagnosis of TB.
Through this study, acceptable analytical performance of novel Alinity i system has been verified. It is expected to readily replace existing instrument and to be an option for laboratories considering introduction of automated immunoassay analyzer.
The assay showed acceptable precision, trueness, linearity, and limit of quantification, and correlated well with LC-MS/MS. Therefore, its analytical performance is satisfactory for monitoring the drug concentration of voriconazole.
Background: Effective treatment and monitoring of tuberculosis (TB) requires biomarkers that can be easily evaluated in blood samples. The aim of this study was to analyze the serum proteome of patients with TB and to identify protein biomarkers for TB. Methods: Serum samples from 26 TB patients and 31 controls were analyzed by using nano-flow ultra-performance liquid chromatography coupled to quadrupole time-of-flight mass spectrometry in data-independent mode, and protein and peptide amounts w
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