최상일 교수
Sang Il Choi
서울대학교 · 의학
연구실 소개
최상일 교수의 연구실은 심혈관 질환과 위암의 분자 기전을 중심으로 한 기초 및 임상 연구를 수행하고 있습니다. 특히 FGF21과 같은 대사 관련 단백질이 심혈관 위험 요인과의 관계를 규명하고, 심장 MRI를 활용한 심근 손상 평가 및 심장 박동성 생체 영상 기술 개발에도 주력하고 있습니다. 또한 헬리코박터 파일로리 감염과 관련된 위암의 전구 병변 및 전이 메커니즘을 분석하여, 갈락토시드-9와 같은 신호 분자들이 암 진행에 미치는 영향을 탐색하고 있습니다.
연구 현황
연구 성과 추이
표시된 성과는 수집된 데이터 기준으로 산출되며, 일부 차이가 있을 수 있습니다.
주요 논문
15The purpose of this study was to correlate the abnormal signal area on various magnetic resonance (MR) images to the infarct area on pathologic examination and to assess the myocardial viability on the basis of MR images. T2-weighted, first-pass perfusion, and delayed gadolinium-enhanced T1-weighted images were used as "one-stop examinations" in a pig model of reperfused myocardial infarction. The results of each MR image were compared with those of 2,3, 5-triphenyltetrazolium chloride (TTC) sta
MR images enhanced with bis-gadolinium mesoporphyrins provide accurate sizing of irreversibly damaged myocardium with a strong and persistent signal enhancement in the reperfused myocardium.
Intestinal-type gastric cancer often results from <i>Helicobacter pylori</i> infection through intestinal metaplasia, a transdifferentiated premalignant phenotype. Because <i>H. pylori</i> virulence factor CagA has been associated with aberrant expression of the transcription factor CDX1, which regulates intestinal differentiation, we explored its relationship with <i>H. pylori</i> infection and function during gastric carcinogenesis in normal gastric epithelial cells and gastric cancer cell lin
Although an asymptomatic population classified as low risk by the NCEP guideline has been regarded as a minimal risk group, the prevalence of atherosclerosis plaques and significant stenosis were not negligible. However, considering very low event rate for those patients, CCTA should not be performed in low-risk asymptomatic subjects, although CCTA might have the potential for identification of high-risk groups in the selected subjects regarded as a minimal-risk group by NCEP guideline.
Tumoral expression of Gal-9 may suppress tumor progression in patients with gastric cancer.
The survival of patients with HCC, especially HBV-related HCC, has improved significantly over time in Korea.
Bone marrow involvement was found in 4.3% of the patients with gastric MALT lymphoma. Bone marrow examination may be deferred because marrow involvement does not change the treatment options or outcome in gastric MALT lymphoma confined to the stomach wall.
In this paper, we propose a new pattern recognition method using feature feedback and present its application to face recognition. Conventional pattern recognition methods extract the features employed for classification using PCA, LDA and so on. On the other hand, in the proposed method, the extracted features are analyzed in the original space using feature feedback. Using reverse mapping from the extracted features to the original space, we can identify the important part of the original data
In this paper, we investigate Lipschitz and asymptotic stability for perturbed nonlinear dierential systems.
In this paper, we investigate bounds for solutions of the perturbed nonlinear functional differential systems with a -similarity condition using the notion of h-stability.
A new model to predict survival of patients with recurrent or progressive hepatocellular carcinoma was developed and validated. This model may be useful for planning subsequent treatments.
The image quality of in vitro DT-MRI is significantly improved as the number of diffusion-sensitizing gradient directions is increased.
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