신상준 교수

<b>Objective:</b> Mucosal melanoma is an aggressive malignancy with a poor response to conventional therapies. The efficacy of radiotherapy (RT), especially combined with immune checkpoint inhibitors (ICIs), for this rare melanoma subtype remains unknown. We investigated the reciprocal effect of RT and ICI on mucosal melanoma patients. <b>Materials and Methods:</b> We identified 23 patients with 31 tumors who were treated with RT between July 2008 and February 2017. All patients received RT for

Upfront chemotherapy and short course RT with delayed surgery is a valuable alternative treatment approach for patients with MRF involvement or closeness of rectal cancer with distant metastases.

Within the framework of blade aerodynamic design, the maximum aerodynamic efficiency, power production, and minimum thrust force are the targets to obtain. This paper describes an improved optimization framework for blade aerodynamic design under realistic conditions, while considering multiple design parameters. The relationship between the objective function and the design parameters, such as the chord length, maximum chord, and twist angle, were obtained by using the second-order response sur

The combined analysis concerning uPA and E-cadherin expression may be a useful predictor of metastasis in pancreatic cancer.

The design and manufacturing of an active twist rotor blade for vibration reduction in helicopters are presented. The rotor blade is integrally twisted by direct strain actuation through embedded piezoelectric fiber composite actuators distributed along the span of the blade. Highlights of the analysis formulation used to design this type of active blade are presented. The requirements for the prototype blade, along with the final design results are also presented. Detailed aspects of its manufa

3007 Background: Belvarafenib, a potent, selective RAF dimer (type II) inhibitor, exhibits clinical activity in BRAF V600E - and NRAS-mutant (NRASm) melanoma patients. The combination of belvarafenib and cobimetinib more potently and durably suppressed MAPK pathway output and tumor growth than currently approved BRAF/MEK inhibitors in RAS- or RAF-mutant tumor xenograft models. This interim results of phase 1b trial evaluated the safety, tolerability, pharmacokinetics, and anti-tumor activity of

An improved data-driven non-intrusive model order reduction (MOR) methodology capable of interpolating time-transient flow-fields and other types of data with respect to the parameters is proposed. The proposed MOR method comprises the following two stages: MOR and interpolation. For the MOR, modified proper orthogonal decomposition (POD) is used to collect the parametrically independent POD modes and dependent coefficients. An interpolation of the POD coefficients is conducted through unsupervi

These findings demonstrated that a strong possibility that upfront chemotherapy and short-course RT with delayed surgery are an effective alternative treatment for LARC with potentially resectable distant metastasis, owing to achievement of pathologic down-staging, R0 resection, and favorable compliance and toxicity, despite the long treatment duration.

Summary This study proposed geometrically nonlinear quadratic solid/solid‐shell elements applicable for moving structures. Coordinates in the corotational (CR) formulation were established for a solid element. The proposed CR formulation was consistent with other hexahedral or tetrahedral solid type finite elements. The study involved an explicit description of relevant quantities induced during the derivation. Centrifugal and inertial terms were derived to analyze the behavior of moving structu

Adjuvant chemotherapy for elderly patients with Stage II colon cancer is not effective, whereas elderly patients with Stage III with adjuvant chemotherapy appear to have a better survival rate in the general population.