이상아 교수

Adipokines, soluble mediators produced by adipocytes, may link adipose tissue to the inflammatory, metabolic, and immune dysregulation that characterize many obesity-related diseases. The stability of plasma adipokine levels within individuals, their seasonal variability, intercorrelations, and relationships to well-established measures of adiposity are incompletely defined. We measured levels of 12 adipokines [interleukin 1beta (IL-1beta), IL-6, IL-8, tumor necrosis factor-alpha (TNF-alpha), pl

The association of animal-origin food consumption and cooking patterns with colorectal cancer (CRC) risk was evaluated in a cohort of 73,224 participants of the Shanghai Women's Health Study. After a mean follow-up time of 7.4 yr, 394 incident cases of CRC (colon = 236; rectal = 158) were diagnosed. Overall, no association was found between the risk of CRC and intake of total meat and total fish. Eel (P(trend) = 0.01), shrimp (P(trend) = 0.06), and shellfish (P(trend) = 0.04) consumption were po

The prevalence of hypertension has increased over the past decade in many developed and developing countries, including China. This increase may be associated with changes in lifestyle, including dietary patterns. We evaluated the association of dietary patterns with blood pressure (BP) by using data from a large, population-based cohort study of middle-aged and elderly Chinese men, the Shanghai Men's Health Study. The present cross-sectional analysis includes 39 252 men who reported no prior hi

To evaluate the interactive effect of methylenetetrahydrofolate reductase (MTHFR) genotype and dietary factors on the development of breast cancer, a hospital based case-control study was conducted in South Korean study population consisting of 189 histologically confirmed incident breast cancer cases and their 189 age-matched controls without present or previous history of cancer. A PCR-RFLP method was used for the genotyping of MTHFR (C677T) and statistical evaluations were performed by uncond

Despite low participation in exercise/sports, most middle-aged and elderly Chinese men in Shanghai participate in a high level of nonexercise PA. Their PA patterns are closely associated with socioeconomic/lifestyle factors.

For differential diagnosis between TBM and VM, we created a new weighted scoring system. This scoring system and decision tree analysis are simple and easy to apply in clinical practice to differentiate TBM from VM.

최근 자연어처리에서 문장 단위의 임베딩을 위한 모델들은 거대한 말뭉치와 파라미터를 이용하기 때문에 큰 하드웨어와 데이터를 요구하고 학습하는 데 시간이 오래 걸린다는 단점을 갖는다. 따라서 규모가 크지 않더라도 학습 데이터를 경제적으로 활용하면서 필적할만한 성능을 가지는 모델의 필요성이 제기된다. 본 연구는 음절 단위의 한국어 사전, 자소 단위의 한국어 사전을 구축하고 자소 단위의 학습과 양방향 WordPiece 토크나이저를 새롭게 소개하였다. 그 결과 기존 모델의 1/10 사이즈의 학습 데이터를 이용하고 적절한 크기의 사전을 사용해 더 적은 파라미터로 계산량은 줄고 성능은 비슷한 KR-BERT 모델을 구현할 수 있었다. 이로써 한국어와 같이 고유의 문자 체계를 가지고 형태론적으로 복잡하며 자원이 적은 언어에 대해 모델을 구축할 때는 해당 언어에 특화된 언어학적 현상을 반영해야 한다는 것을 확인하였다.

Since the appearance of BERT, recent works including XLNet and RoBERTa utilize sentence embedding models pre-trained by large corpora and a large number of parameters. Because such models have large hardware and a huge amount of data, they take a long time to pre-train. Therefore it is important to attempt to make smaller models that perform comparatively. In this paper, we trained a Korean-specific model KR-BERT, utilizing a smaller vocabulary and dataset. Since Korean is one of the morphologic

Although a plethora of high-performance film cooling hole configurations have been suggested, they are too complicated to manufacture and extremely difficult to maintain their original shapes during turbine operation. Thus, it is assumed that there is little room for further performance improvement by optimizing a single hole shape. However, optimization researches on the arrangement of the film cooling holes are still insufficient, so investigation of the possibility of the optimal hole array f

The use of DTG/DRV/c in HIV treatment-experienced patients appears to be a very good regimen for switch therapy that is effective and well tolerated, without significant adverse drug reaction.

A high-fidelity yet affordable design procedure is proposed for a film-cooling hole array optimization and subsequently applied to the array on the nozzle pressure side of the high-pressure turbine. To make this possible, the efficient array shape parameterization method combined with the efficient global optimization method is introduced. As a result of optimization, the average and variation of the wall temperature are reduced by approximately 10 and 25%, respectively. Also, it is confirmed fr

Despite several studies on the optimum shape of film cooling holes, only a small number of research efforts have attempted to optimize the hole arrangement for film cooling. Moreover, although the manufacturing tolerance has substantial effects on the performance of film cooling, the studies on this issue are even scarcer. The present study proposed a robust design optimization procedure that takes the manufacturing uncertainties into account; it was subsequently applied to the film holes on a h

In spite of a myriad of researches on the optimal shape of film cooling holes, only a few attempts have been made to optimize the hole arrangement for film cooling so far. Moreover, although the general scale of film cooling hole is so small that manufacturing tolerance has substantial effects on the cooling performance of turbine, the researches on this issue are even scarcer. If it is possible to obtain optimal hole arrangement which not only improve the film cooling performance but also is ro