김석호 교수

Inflammatory bowel disease is known as the most chronic inflammatory disorder in colon, which subsequently progresses to intestinal obstruction and fistula formation. Many studies to date for the treatment of IBD have been focused on inflammation. However, most of the anti-inflammatory agents do not have anti-fibrotic effects and could not relieve intestinal stricture in IBD patients. Because preventing or reversing intestinal fibrosis in IBD is a major therapeutic target, we analyzed the papers

Abstract The aza‐Claisen rearrangement, also known as the 3‐aza‐Cope rearrangement, has attracted significant attention because it can be used as a complimentary method to access a diverse range of useful organic molecules. The presence of a nitrogen atom at the 3‐position enables the tethering of various‐sized azacycles, thereby giving ring‐expansion strategies that take advantage of the aza‐Claisen rearrangement a distinct advantage compared to other [3,3]‐sigmatropic rearrangements. Recent ad

Quinazolines are a class of nitrogen-containing heterocyclic compounds with broad-spectrum of pharmacological activities. Transition-metal-catalyzed reactions have emerged as reliable and indispensable tools for the synthesis of pharmaceuticals. These reactions provide new entries into pharmaceutical ingredients of continuously increasing complexity, and catalysis with these metals has streamlined the synthesis of several marketed drugs. The last few decades have witnessed a tremendous outburst

Yes-associated protein (YAP)-1 is highly upregulated in pancreatic cancer and associated with tumor progression. However, little is known about the role of YAP1 and related genes in pancreatic cancer. Here, we identified target genes regulated by YAP1 and explored their role in pancreatic cancer progression and the related clinical implications. Analysis of different pancreatic cancer databases showed that Neuromedin U (NMU) expression was positively correlated with YAP1 expression in the tumor

Obesity, characterized by excess lipid accumulation, has emerged as a leading public health problem. Excessive, adipocyte-induced lipid accumulation raises the risk of metabolic disorders. Adipose-derived stem cells (ASCs) are mesenchymal stem cells (MSCs) that can be obtained from abundant adipose tissue. High fat mass could be caused by an increase in the size (hypertrophy) and number (hyperplasia) of adipocytes. Reactive oxygen species (ROS) are involved in the adipogenic differentiation of h

YM155 is a clinically evaluated anticancer with a fused naphthoquinone-imidazolium scaffold. In this study, we demonstrated that based on weak or cryptic antibacterial activity of YM155 against methicillin-resistant <i>Staphylococcus aureus</i> (MRSA) (MIC of 50 μg/ml), some congeneric compounds with short alkyl chains (e.g., c5 with a hexyl chain) at the N3 position of the scaffold, displayed more potent antibacterial activity against MRSA (MIC of 3.13 μg/ml), which is in a clinically achievabl

Cancer cachexia is a highly debilitating condition characterized by weight loss and muscle wasting that contributes significantly to the morbidity and mortality of pancreatic cancer. The factors that induce cachexia in pancreatic cancer are largely unknown. We previously showed that pancreatic adenocarcinoma upregulated factor (PAUF) secreted by pancreatic cancer cells is responsible for tumor growth and metastasis. Here, we analyzed the relation between pancreatic cancer-derived PAUF and cancer

We experimentally demonstrate the simultaneous enhancement of Raman and photoluminescence (PL) of core-shell hybrid nanoparticles consisting of Ag (core) and polydiacetylene (PDA, shell) through the assistance of localized surface plasmon (LSP) effect for the effective biosensor. Core-shell nanoparticles (NPs) are fabricated in deionized water through a sequential process of reprecipitation and self-assembly. The Raman signal of PDA on core-shell NPs is enhanced more than 100 times. Also, highly

A mild and highly efficient metal-free oxidative α-cyanation of <i>N</i>-acyl/sulfonyl 1,2,3,4-tetrahydroisoquinolines (THIQs) has been accomplished at an ambient temperature via DDQ oxidation and subsequent trapping of <i>N</i>-acyl/sulfonyl iminium ions with (<i>n</i>-Bu)₃SnCN. Employing readily removable <i>N</i>-acyl/sulfonyl groups as protecting groups rather than <i>N</i>-aryl ones enables a wide range of applications in natural product synthesis. The synthetic utility of the method was il

Despite numerous reports on the beneficial effects of catechin or epicatechin contained in tea and cacao extract on human health, a conclusive and precise molecular mechanism has not been elucidated. Metabolism of chemical compounds in gut microbiota recently gained significant attention, and extensive studies have been devoted in this field. In conjunction with these results, our group focused on the anti-inflammatory effects of both enantiomers of DHPV (5-(3',4'-dihydroxyphenyl)-γ-valerolacton

Arylnaphthalene lignan lactones belong to a class of natural lignans, and more than 60 analogs have been isolated. Their pharmacological activities as well as unique structural features have attracted considerable attention from medicinal and synthetic chemists. Since the first synthesis in 1895, many synthetic methodologies with ionic or pericyclic reaction mechanisms have been reported. Transition metal catalysts sometimes provide exceptional synthetic versatility for the syntheses of natural

Pyrimidine is a privileged scaffold in many synthetic compounds exhibiting diverse pharmacological activities, and is used for therapeutic applications in a broad spectrum of human diseases. In this study, we prepared a small set of pyrimidine libraries based on the structure of two hit compounds that were identified through the screening of an in-house library in order to identify an inhibitor of anoctamin 1 (ANO1). ANO1 is amplified in various types of human malignant tumors, such as head and

이 논문은 한국에서 청년이 결혼과 출산을 어떻게 생각하고 있으며, 결혼과 출산에 대한 기피가 그들의 마음에서 왜 형성되는가를 살펴본다. 이 논문은 비혼과 출산 포기를 설명하기 위해서는 현재 가용한 자원의 부족과 어려운 현실에 대한 인식과 더불어 미래의 불확실성에 대한 불안이 가진 영향력을 살펴봐야 한다는 전제에서 출발한다. 즉 기존 청년 담론에서 핵심적 위치를 점하고 있는 일자리나 소득 등 사회경제적 요인뿐 아니라 꿈이나 미래에 대한 전망과 같은 사회심리적 요인도 함께 고려하는 것이 청년의 비혼과 출산 기피를 이해하는 데 도움이 될 것이라 보았다. 분석의 결과, 청년의 비혼과 출산 기피는 일자리와 소득 등 사회경제적 자원의 결핍뿐 아니라 불확실한 미래에 대한 불안이 중요한 요인임을 확인하였다. 청년 자신이 보유하고 있는 객관적 자원보다는 자신의 현재와 미래에 대한 주관적 인식이 청년들의 결혼과 출산에 대한 꿈과 가능성에 영향을 미친다는 사실을 보여주었다. 특히 미래에 예상하는 계층