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이승표 교수

Seung-Pyo Lee

서울대학교 내과학교실 · 의학

연구실 소개

이승표 교수의 연구실은 심장질환의 조기 진단과 생체재료의 혁신적 개발을 중심으로 활동하고 있습니다. 특히 퇴행성 심장질환인 대동맥판막질환과 비정상적인 심장 리듬 장애인 심방세동의 유전적 기반을 규명하고, 환경 오염물질이 심장 동맥 판막에 미치는 영향을 분석하는 데 초점을 맞추고 있습니다. 또한, 생체에 통합 가능한 유연한 전도성 나노소재 개발을 통해 미래형 의료기기의 실현 가능성을 모색하고 있습니다.

심장질환생체재료나노소재유전자환경오염물질

연구 현황

논문 수
444
총 인용 수
7,833
최근 5년 논문
90
주요 분야
의학

연구 성과 추이

표시된 성과는 수집된 데이터 기준으로 산출되며, 일부 차이가 있을 수 있습니다.

5개년 연도별 논문 게재 수
90총합
2022
2023
2024
2025
2026
5개년 연도별 피인용 수
1,307총합
20222023202420252026

주요 논문

15
1
논문|인용수 169·2014
11C-Pittsburgh B PET Imaging in Cardiac Amyloidosis
Seung‐Pyo Lee, Eun Seong Lee, Hongyoon Choi, Hyung‐Jun Im, Youngil Koh, Min‐Ho Lee, Ji‐Hyun Kwon, Jin Chul Paeng, Hyung‐Kwan Kim, Gi Jeong Cheon, Yong‐Jin Kim, Inho Kim
SJR Q1FWCI 4.1JACC. Cardiovascular imaging
Molecular BiologyBiochemistry, Genetics and Molecular Biology
2
논문|인용수 142·2014
Assessment of Diffuse Myocardial Fibrosis by Using MR Imaging in Asymptomatic Patients with Aortic Stenosis
Seung‐Pyo Lee, Whal Lee, Joo Myung Lee, Eun‐Ah Park, Hyung‐Kwan Kim, Yong‐Jin Kim, Dae‐Won Sohn
SJR Q1FWCI 8.9Radiology

Native T1 mapping provides a noninvasive estimation of diffuse myocardial fibrosis and correlates with subclinical myocardial dysfunction in asymptomatic patients with AS.

Cardiology and Cardiovascular MedicineMedicine
3
논문|인용수 122·2017
Noncontrast Myocardial T1 Mapping by Cardiac Magnetic Resonance Predicts Outcome in Patients With Aortic Stenosis
Heesun Lee, Jun‐Bean Park, Yeonyee E. Yoon, Eun‐Ah Park, Hyung‐Kwan Kim, Whal Lee, Yong‐Jin Kim, Goo‐Yeong Cho, Dae‐Won Sohn, Andreas Greiser, Seung‐Pyo Lee
SJR Q1FWCI 11.6JACC. Cardiovascular imaging
Radiology, Nuclear Medicine and ImagingMedicine
4
논문|인용수 106·2006
Integrin-Linked Kinase, a Hypoxia-Responsive Molecule, Controls Postnatal Vasculogenesis by Recruitment of Endothelial Progenitor Cells to Ischemic Tissue
Seung‐Pyo Lee, Seock‐Won Youn, Hyun‐Jai Cho, Lian Li, Tae Youn Kim, Hyung-Seon Yook, Jae-Woong Chung, Jin Hur, Chang‐Hwan Yoon, Kyung Woo Park, Byung‐Hee Oh, Young-Bae Park
SJR Q1FWCI 4.2CirculationOA

Endogenous ILK is a novel and physiological upstream responder of numerous intracellular molecules involved in hypoxic stress in ECs and may control the recruitment of EPCs to ischemic tissue.

Molecular BiologyBiochemistry, Genetics and Molecular Biology
5
논문|인용수 84·2019
PM2.5 concentration in the ambient air is a risk factor for the development of high-risk coronary plaques
Seokhun Yang, Seung‐Pyo Lee, Jun‐Bean Park, Heesun Lee, Si‐Hyuck Kang, Sang‐Eun Lee, Juyong Brian Kim, Su‐Yeon Choi, Yong‐Jin Kim, Hyuk‐Jae Chang
SJR Q1FWCI 5.3European Heart Journal - Cardiovascular ImagingOA

Exposure to higher concentration of PM2.5 in the ambient air is significantly associated with the development of high-risk coronary plaques.

Health, Toxicology and MutagenesisEnvironmental Science
6
논문|인용수 78·2023
Stretchable Low-Impedance Conductor with Ag–Au–Pt Core–Shell–Shell Nanowires and in Situ Formed Pt Nanoparticles for Wearable and Implantable Device
Sung‐Hyuk Sunwoo, Sang Ihn Han, Dongjun Jung, Minseong Kim, Seonghyeon Nam, Hyunjin Lee, Suji Choi, Hyejeong Kang, Ye Seul Cho, Da‐Hae Yeom, Myung‐Jin Cha, Seunghwan Lee
SJR Q1FWCI 8.6ACS Nano

Mechanically soft metallic nanocomposites have gained much attention as a key material for intrinsically stretchable biointegrated devices. However, it has been challenging to develop a stretchable conductive nanocomposite with all the desired material characteristics including high conductivity, high stretchability, low cytotoxicity, and low impedance. Here, we present a material strategy for the stretchable conductive nanocomposite, particularly emphasizing low impedance, by combining silver-g

Biomedical EngineeringEngineering
7
논문|인용수 76·2008
Surface Characteristics of Orthodontic Materials and Their Effects on Adhesion of Mutans streptococci
Seung‐Pyo Lee, Shin‐Jae Lee, Bum‐Soon Lim, Sug‐Joon Ahn
SJR Q1FWCI 1.1The Angle OrthodontistOA

The hypothesis is rejected. This study suggests that SFE characteristics play an important role in the initial MS adhesion to orthodontic materials.

OrthodonticsDentistry
8
논문|인용수 76·2018
Incident Atrial Fibrillation Is Associated With <i>MYH7</i> Sarcomeric Gene Variation in Hypertrophic Cardiomyopathy
Seung‐Pyo Lee, Euan A. Ashley, Julian R. Homburger, Colleen Caleshu, Eric M. Green, Daniel Jacoby, Steven D. Colan, Edmundo Arteaga-Fernández, Sharlene M. Day, Francesca Girolami, Iacopo Olivotto, Michelle Michels
SJR Q1FWCI 3.9Circulation Heart FailureOA

Background Although atrial fibrillation (AF) is common in hypertrophic cardiomyopathy (HCM) patients, the relationship between genetic variation and AF has been poorly defined. Characterizing genetic subtypes of HCM and their associations with AF may help to improve personalized medical care. We aimed to investigate the link between sarcomeric gene variation and incident AF in HCM patients. Methods and Results Patients from the multinational Sarcomeric Human Cardiomyopathy Registry were followed

Cardiology and Cardiovascular MedicineMedicine
9
논문|인용수 71·2019
Stretchable Low‐Impedance Nanocomposite Comprised of Ag–Au Core–Shell Nanowires and Pt Black for Epicardial Recording and Stimulation
Sung‐Hyuk Sunwoo, Sang Ihn Han, Hyejeong Kang, Ye Seul Cho, Dongjun Jung, Chanhyuk Lim, Chaehong Lim, Myung‐Jin Cha, Seung‐Pyo Lee, Taeghwan Hyeon, Dae‐Hyeong Kim
SJR Q1FWCI 2.7Advanced Materials Technologies

Abstract Cardiac resynchronization therapy (CRT) presents effective means to modulate cardiac conduction and related functions in heart failure patients. However, the conventional CRT delivers electric current at only two points on the heart, therefore, it is unable to provide comprehensive electrical support to the heart. Additionally, the CRT‐device structure faces several issues, such as those associated with the endocardial screw tip, which may cause myocardial degeneration, and the metal le

Biomedical EngineeringEngineering
10
논문|인용수 62·2020
Pittsburgh B Compound Positron Emission Tomography in Patients With AL Cardiac Amyloidosis
Seung‐Pyo Lee, Hoon-Young Suh, Sohyun Park, Sera Oh, Soongu Kwak, Hyue Mee Kim, Youngil Koh, Jun‐Bean Park, Hyung‐Kwan Kim, Hyun‐Jai Cho, Yong‐Jin Kim, Inho Kim
SJR Q1FWCI 2.9Journal of the American College of Cardiology
Molecular BiologyBiochemistry, Genetics and Molecular Biology
11
논문|인용수 58·2017
Noninvasive Imaging of Myocardial Inflammation in Myocarditis using <sup>68</sup>Ga-tagged Mannosylated Human Serum Albumin Positron Emission Tomography
Seung‐Pyo Lee, Hyung‐Jun Im, Shinae Kang, Seock‐Jin Chung, Ye Seul Cho, Hyejeong Kang, Ho Seon Park, Do-Won Hwang, Jun‐Bean Park, Jin-Chul Paeng, Gi Jeong Cheon, Yun‐Sang Lee
SJR Q1FWCI 4.5TheranosticsOA

The diagnosis of myocarditis traditionally relies on invasive endomyocardial biopsy but none of the imaging studies so far are specific for infiltration of the inflammatory cells itself. We synthesized <sup>68</sup>Ga-2-(p-isothiocyanatobenzyl)-1,4,7-triazacyclononane-1,4,7-triacetic acid (NOTA) mannosylated human serum albumin (MSA) by conjugating human serum albumin with mannose, followed by conjugation with NOTA and labeling it with <sup>68</sup>Ga. The efficacy of <sup>68</sup>Ga-NOTA-MSA po

Cardiology and Cardiovascular MedicineMedicine
12
논문|인용수 50·2021
Supplementary role of left ventricular global longitudinal strain for predicting sudden cardiac death in hypertrophic cardiomyopathy
Hyun‐Jung Lee, Hyung‐Kwan Kim, Sang‐Chol Lee, Sang‐Chol Lee, Jihoon Kim, Jun Bean Park, In Chang Hwang, You Jung Choi, Seung‐Pyo Lee, Seung‐Pyo Lee, Sung‐A Chang, Whal Lee
SJR Q1FWCI 4.9European Heart Journal - Cardiovascular Imaging

LV-GLS is an important prognosticator in patients with HCM and provides additional information to established risk stratification strategies for predicting SCD.

Cardiology and Cardiovascular MedicineMedicine
13
논문|인용수 48·2019
The effect of scanning distance on the accuracy of intra‐oral scanners used in dentistry
Min‐Kyoung Kim, Jimin Kim, Yoo‐Mee Lee, Young‐Jun Lim, Seung‐Pyo Lee
SJR Q1FWCI 3.5Clinical Anatomy

The aim of this study was to evaluate the factors affecting intra-oral scanner accuracy by analyzing variation in measurements of a dental model according to scanning distance. A dental cast, including a prepared left mandibular first molar, was used. Rectangular frames measuring 20 × 30 mm with heights of 2.5, 5.0, and 7.5 mm were made. The model was scanned 10 times with a reference scanner to obtain the true value. Scanning was performed 10 times at four distances of 0, 2.5, 5.0, and 7.5 mm w

Oral SurgeryDentistry
14
논문|인용수 47·2023
Ventricular tachyarrhythmia treatment and prevention by subthreshold stimulation with stretchable epicardial multichannel electrode array
Sung‐Hyuk Sunwoo, Myung‐Jin Cha, Sang Ihn Han, Hyejeong Kang, Ye Seul Cho, Da‐Hae Yeom, Chan Soon Park, Na Kyeong Park, Seong Woo Choi, Sung Joon Kim, Gi Doo, Dongjun Jung
SJR Q1FWCI 10.3Science AdvancesOA

The implantable cardioverter-defibrillator (ICD) is an effective method to prevent sudden cardiac death in high-risk patients. However, the transvenous lead is incompatible with large-area electrophysiological mapping and cannot accommodate selective multichannel precision stimulations. Moreover, it involves high-energy shocks, resulting in pain, myocardial damage, and recurrences of ventricular tachyarrhythmia (VTA). We present a method for VTA treatment based on subthreshold electrical stimula

Cardiology and Cardiovascular MedicineMedicine
15
논문|인용수 47·2024
Highly Conductive and Stretchable Hydrogel Nanocomposite Using Whiskered Gold Nanosheets for Soft Bioelectronics
Chaehong Lim, Sunwoo Lee, Seunghwan Lee, Hyejeong Kang, Ye Seul Cho, Da‐Hae Yeom, Sung‐Hyuk Sunwoo, Chansul Park, Seonghyeon Nam, Jeong Hyun Kim, Seung‐Pyo Lee, Seung‐Pyo Lee
SJR Q1FWCI 8.7Advanced MaterialsOA

The low electrical conductivity of conductive hydrogels limits their applications as soft conductors in bioelectronics. This low conductivity originates from the high water content of hydrogels, which impedes facile carrier transport between conductive fillers. This study presents a highly conductive and stretchable hydrogel nanocomposite comprising whiskered gold nanosheets. A dry network of whiskered gold nanosheets is fabricated and then incorporated into the wet hydrogel matrices. The whiske

Biomedical EngineeringEngineering

대표 연구 분야

Cardiology and Cardiovascular MedicineAerospace EngineeringRadiology, Nuclear Medicine and ImagingCivil and Structural EngineeringOral SurgeryBiomedical Engineering

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