정승용 교수

The present findings suggest that compared with a 4 to 6 week interval, delaying surgery for 6 to 8 weeks after completion of fractionated radiotherapy with concurrent chemotherapy does not improve CRT response or the sphincter-preservation rate, and does not decrease morbidity or local recurrence.

Approximately 16 percent of patients with submucosally invasive colorectal carcinoma and risk factors benefited from subsequent surgery. Tumor budding was the most significant factor for lymph node metastasis. Observation would be appropriate for patients without risk factors after endoscopic resection.

Depth of mesorectal extension >5 mm is a significant prognostic factor in patients with T3 rectal cancer. Depth of mesorectal extension especially may be more important than the nodal status in predicting the oncologic outcome for patients who had received preoperative chemoradiotherapy.

The results indicated that a germline mutation of DNA mismatch repair gene was a rare event in sporadic colorectal cancers.

Intratumor heterogeneity (ITH) stands as one of the main difficulties in the treatment of colorectal cancer (CRC) as it causes the development of resistant clones and leads to heterogeneous drug responses. Here, 12 sets of patient-derived organoids (PDOs) and cell lines (PDCs) isolated from multiple regions of single tumors from 12 patients, capturing ITH by multiregion sampling of individual tumors, are presented. Whole-exome sequencing and RNA sequencing of the 12 sets are performed. The PDOs

ABSTRACT: The intense and complex flavor characteristics of soy sauce makes it very difficult to obtain a comprehensive sensory profiling, and an effective descriptive analysis protocol for soy sauce products has not yet been established. The aims of this study were (1) to establish an objective, effective, and powerful descriptive analysis procedure that can be used to understand the sensory characteristics of soy sauce products and (2) to evaluate the sensory characteristics of 6 fermented typ

A metastasis of colorectal cancer is difficult to diagnose, and has a poor prognosis. Therefore, we tried to elucidate the possibility of a diagnostic and prognostic marker. Exosomal miR-193a and let-7g were sorted by miRNA microarray. The expression of miR-193a in the PTM group was lower than that of the primary CRC group, and the expression of let-7g was higher than that of the primary CRC. MMP16 and CDKN1A expression was confirmed respectively for target genes of two miRNAs. When the mimics o

The seismic performance evaluation of a 49-story residential building under construction in Seoul, Korea is the subject of this paper. The building for this case study has an irregular plan and a deep basement shared with adjacent buildings. A series of nonlinear time history analyses were carried out for the Maximum Considered Earthquake (MCE) and Rare Earthquake (RE). Effects of modeling methods of the basement were studied. Modeling of the surrounding underground structure included transfer o

Surgical resection may be beneficial in selected patients with ovarian metastasis arising from CRC, when metastasis is limited to the pelvis.

Performance-based wind design (PBWD) allowing inelastic behavior under extreme wind load has only been recently considered for design of high-rise buildings. Unlike performance-based seismic design, there are few guidelines and research on inelastic wind design. Time-history wind loads for PBWD rely on wind tunnel tests. However, conducting wind tunnel tests for preliminary structural concepts may not be practical due to changes in design and cost. To address these concerns, the following topics

Stages II and III of the newly revised tumor-node-metastasis staging system for colon cancer (American Joint Committee on Cancer [AJCC] Staging Manual sixth edition) differ from those in the fi fth edition ( 1 ) . In the sixth edition, stage II is subdivided into IIa (T3N0) and IIb (T4N0) and stage III is subdivided into IIIa (T1 -2N1M0), IIIb (T3 -4N1M0), and IIIc (anyTN2M0). This stratifi ed grouping was motivated by the large difference in survival between stage II and III patients noted in t

Our findings demonstrated the importance of filter selection for sampling AM.