강시혁 교수
Si-Hyuck Kang
서울대학교 · 의학
연구실 소개
강시혁 교수의 연구실은 심혈관질환의 예방과 관리에 중점을 두고 있으며, 특히 고혈압, 심 heart failure, 혈관 스텐트의 생체적합성 및 공기오염과 심장 arrhythmia 간의 연관성에 대한 기초 및 임상 연구를 수행하고 있습니다. 구체적으로, 구강건강 관리가 심혈관 질환 예방에 기여할 수 있음을 규명하고, 다양한 스텐트의 안전성과 약물 방출 메커니즘의 최적 조합을 분석하는 데에도 기여하고 있습니다. 또한, 생체마커인 NT-proBNP의 예후적 의미와 미세먼지 노출이 심방세동 유발에 미치는 영향에 대한 장기적 추세 분석도 진행 중입니다.
연구 현황
연구 성과 추이
표시된 성과는 수집된 데이터 기준으로 산출되며, 일부 차이가 있을 수 있습니다.
주요 논문
15Individuals with CVD may benefit from physical activity to a greater extent than do healthy subjects without CVD.
Oral hygiene care such as frequent tooth brushing and regular dental visits for professional cleaning reduced the risk of future cardiovascular events in healthy adults. This study also suggests that improved oral hygiene behaviour may modify the association between oral health and cardiovascular diseases.
All DESs but PES and ZES-E were superior to BMS in terms of ST within 1 year. Cobalt-chromium everolimus-eluting stents was safer than any DES even including BP-BES. Our results suggest that not only the biodegradability of polymer, but the optimal combination of stent alloy, design, strut thickness, polymer, and drug all combined determine the safety of DES.
Plasma level of NT-proBNP is the most powerful prognostic factor in both HFpEF and HFrEF. Although patients with HFpEF have lower NT-proBNP levels, the prognosis of a patient with HFpEF expected from a given NT-proBNP level is similar with his/her counterpart with HFrEF.
The purpose of the present study was to describe the temporal trends in prevalence and management status of hypertension in Korea between 1998 and 2015. Data of adults who were aged 30 years or older were extracted from the Korea National Health and Nutrition Examination Survey, a nationwide representative population-based survey. Hypertension was prevalent in 30.5% of Korean adults. The age and sex standardized prevalence showed little change between 1998 and 2015. The elderly population and me
This study suggests that short-term exposure to PM<sub>2.5</sub> triggers atrial fibrillation. However, we found no evidence linking atrial fibrillation with long-term exposure to air pollution.
Elevated BP is a strong predictor of future cardiovascular events including cardiac death, myocardial infarction, stroke, and heart failure. This study showed that the log-linear relationship between BP and cardiovascular events extended down to a BP of ≥90/40 mmHg. Although hypertension is defined using a lower systolic BP cut-off of ≥130 mmHg, the diastolic BP component of ≥80 mmHg seems disproportionately low.
ClinicalTrials.gov NCT03273803; https://clinicaltrials.gov/ct2/show/NCT03273803 (Archived by WebCite at http://www.webcitation.org/6x6g1fHIu).
Korean NVAF patients had high risk of stroke and mortality, and had multiple comorbidities. While both CHADS<sub>2</sub>and CHA<sub>2</sub>DS<sub>2</sub>-VASc schema had good performance in risk prediction, CHA<sub>2</sub>DS<sub>2</sub>-VASc score was superior in identifying truly low-risk patients. Given that Asian ethnicity is associated with bleeding events, individualized accurate risk prediction is necessary to improve patient outcomes.
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