김성재 교수
Sungjae Kim
서울대학교 · 의학
연구실 소개
김성재 교수의 연구실은 나노유체역학과 전기화학적 현상의 융합을 핵심으로 하며, 특히 이온 농도 극화(ICP) 현상과 그 기반 메커니즘을 깊이 있게 탐구하고 있습니다. 고분자 기반 나노다공구조를 활용한 마이크로유체 장치를 설계하여 표면 전도도 향상과 전기오스모시스를 통한 유체 흐름 제어를 실현하고 있으며, 이는 바이오분자 농축 및 센싱 응용에 기여합니다. 또한, 전기장 분포 및 유동장의 직접 측정을 통해 ICP 현상의 이론적 기초를 실험적으로 입증하고 있습니다.
연구 현황
연구 성과 추이
표시된 성과는 수집된 데이터 기준으로 산출되며, 일부 차이가 있을 수 있습니다.
주요 논문
15Abstract Ion concentration polarization (ICP) is a fundamental electrokinetic process that occurs near a perm-selective membrane under dc bias. Overall process highly depends on the current transportation mechanisms such as electro-convection, surface conduction and diffusioosmosis and the fundamental characteristics can be significantly altered by external parameters, once the permselectivity was fixed. In this work, a new ICP device with a bifurcated current path as for the enhancement of the
A perm-selective nanochannel could initiate concentration polarization near the nanochannel, significantly decreasing (increasing) the ion concentration in the anodic (cathodic) end of the nanochannel. Such strong concentration polarization can be induced even at moderate buffer concentrations because of local ion depletion (therefore thicker local Debye layer) near the nanochannel. In addition, fast fluid vortices were generated at the anodic side of the nanochannel due to the nonequilibrium el
Recently, a new type of electrokinetic concentration devices has been developed in a microfluidic chip format, which allows efficient trapping and concentration of biomolecules by utilizing ion concentration polarization near nanofluidic structures. These devices have drawn much attention not only due to their potential application in biomolecule sensing, but also due to the rich scientific content related to ion concentration polarization, the underlying physical phenomenon for the operation of
Deficiency of TGF-beta signalling specifically in the intestine contributes to the development of IBD. Maintenance of TGF-beta signalling may be important in regulating immune homeostasis in the intestine
Ion concentration polarization is the fundamental transport phenomenon that occurs near ion-selective membranes, but this important membrane phenomenon has been poorly understood due to theoretical and experimental challenges. Here, we report the first direct measurements of detailed flow and electric potential profiles within and near the depletion region. This work is an important step toward a full characterization of this coupled transport problem. Using microfabricated electrodes integrated
Level IV, therapeutic case series.
The complete repair group with an aggressive release had no better clinical or structural outcomes compared with the partial repair group with margin convergence alone for large-to-massive contracted rotator cuff tears. In addition, the complete repair group had a 91% retear rate and a greater defect on follow-up MRA images. Even though this study had a relatively short-term follow-up, a complete repair of large-to-massive contracted rotator cuff tears, with an aggressive release such as posteri
We present the operative technique and clinical results of concomitant reconstruction of the medial collateral ligament (MCL) and the posterior oblique ligament for medial instability of the knee using autogenous semitendinosus tendon with preservation of the tibial attachment. The semitendinosus tendon graft between the screw on the medial epicondyle and the tibial attachment of the graft was overlapped by the MCL, while the graft between the screw and the insertion of the direct head of the se
This study describes the long-term clinical results and serial changes of postoperative range of motion after arthroscopic treatment for limitation of motion of the elbow. Sixty-three patients with limitation of motion of the elbow were treated with arthroscopic procedures. The total range of motion was 79 degrees before surgery. The range of motion showed a progressive increase until 1 year after surgery (mean, 121 degrees). However, after 1 year, the range of motion showed little additional in
In 147 patients with arthroscopically proved chronic injuries of the anterior cruciate ligament, the anterior drawer test, the Lachman test, and the pivot shift test were done before operation under general or spinal anesthesia. Results of the anterior drawer test were positive in 79.6% of the patients, in 98.6% patients having the Lachman test, and in 89.8% of patients having the pivot shift test. In 19 cases (12.9%), arthroscopic examination showed reattachment of the proximally torn end of th
Purpose The purpose of this study was to evaluate and compare postoperative anterior knee pain, knee stability, and functional scores of an autogenous bone–patellar tendon–bone (BPTB) graft and a quadriceps tendon–bone (QTB) graft. Methods A total of 48 patients—27 who had anterior cruciate ligament (ACL) reconstruction by use of an autogenous BPTB graft and 21 who had ACL reconstruction by use of a QTB graft—were assessed at a minimum follow‐up of 24 months after surgery. An accelerated rehabil
Twenty-five patients with limitation of motion of the elbow joint caused by the intraarticular pathologies were treated with the following arthroscopic procedures: removal of loose bodies, excision of osteophytes, anterior capsular release, abrasion arthroplasty, and partial excision of the radial head. The extension of the elbow improved by 7 degrees, from a preoperative average of 21 degrees to a postoperative average of 14 degrees. The flexion of the elbow improved by 17 degrees, from a preop
Arthroscopic procedures can be used to treat tibial avulsion fractures of the posterior cruciate ligament.
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