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김태현 교수

Tae Hyun Kim

서울대학교 · 의학

연구실 소개

김태현 교수의 연구실은 나노소재의 생체안정성과 세포 독성 메커니즘을 중심으로, 특히 은 나노입자( AgNPs )의 크기별 세포 독성 영향을 체계적으로 분석하고 있습니다. 동시에 영상 복원 기술 분야에서도 동적 환경에서 발생하는 다양한 블러(카메라 흔들림, 다중 운동 객체 등)를 정밀하게 복원할 수 있는 신호 처리 기반의 혁신적 알고리즘을 개발하고 있습니다. 특히 운동 세분화 없이도 국소적으로 변화하는 블러를 처리할 수 있는 에너지 최적화 모델과 광학 흐름 기반 영상 복원 기법을 핵심으로 연구를 전개하고 있습니다. 또한 생물학적 수용체를 기반으로 한 고해상도 냄새 감지 센서 기술을 통해 바이오센서와 신약 개발 플랫폼의 가능성도 탐색하고 있습니다.

나노입자 독성영상 복원운동 블러광학 흐름바이오센서

연구 현황

논문 수
432
총 인용 수
24,102
최근 5년 논문
37
주요 분야
의학

연구 성과 추이

표시된 성과는 수집된 데이터 기준으로 산출되며, 일부 차이가 있을 수 있습니다.

5개년 연도별 논문 게재 수
37총합
2022
2023
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2025
2026
5개년 연도별 피인용 수
854총합
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주요 논문

15
1
논문|인용수 476·2012
Size‐dependent cellular toxicity of silver nanoparticles
Tae Hyun Kim, Meeju Kim, Hyung‐Seok Park, Ueon Sang Shin, Myoung‐Seon Gong, Hae‐Won Kim
SJR Q1FWCI 17.2Journal of Biomedical Materials Research Part A

Silver nanoparticles (AgNPs) have found a variety of uses including biomedical materials; however, studies of the cytotoxicity of AgNPs by size effects are only in the beginning stage. In this study, we examined the size-dependent cellular toxicity of AgNPs using three different characteristic sizes (∼ 10, 50, and 100 nm) against several cell lines including MC3T3-E1 and PC12. The cytotoxic effect determined based on the cell viability, intracellular reactive oxygen species generation, lactate d

Materials ChemistryMaterials Science
2
논문|인용수 322·2007
Lateral Lymph Node Metastasis Is a Major Cause of Locoregional Recurrence in Rectal Cancer Treated with Preoperative Chemoradiotherapy and Curative Resection
Tae Hyun Kim, Seung‐Yong Jeong, Dong Hyun Choi, Dae Yong Kim, Kyung Hae Jung, Sung Ho Moon, Hee Jin Chang, Seok‐Byung Lim, Hyo Seong Choi, Jae‐Gahb Park
SJR Q1FWCI 2.6Annals of Surgical Oncology
OncologyMedicine
3
논문|인용수 208·2020
Proton beam radiotherapy vs. radiofrequency ablation for recurrent hepatocellular carcinoma: A randomized phase III trial
Tae Hyun Kim, Young Hwan Koh, Bo Hyun Kim, Min Ju Kim, Ju Hee Lee, Boram Park, Joong‐Won Park
SJR Q1FWCI 14.3Journal of Hepatology
HepatologyMedicine
4
논문|인용수 202·2014
Segmentation-Free Dynamic Scene Deblurring
Tae Hyun Kim, Kyoung Mu Lee
FWCI 8.6

Most state-of-the-art dynamic scene deblurring methods based on accurate motion segmentation assume that motion blur is small or that the specific type of motion causing the blur is known. In this paper, we study a motion segmentation-free dynamic scene deblurring method, which is unlike other conventional methods. When the motion can be approximated to linear motion that is locally (pixel-wise) varying, we can handle various types of blur caused by camera shake, including out-of-plane motion, d

Computer Vision and Pattern RecognitionComputer Science
5
논문|인용수 192·2013
Dynamic Scene Deblurring
Tae Hyun Kim, Byeongjoo Ahn, Kyoung Mu Lee
FWCI 6.1

Most conventional single image deblurring methods assume that the underlying scene is static and the blur is caused by only camera shake. In this paper, in contrast to this restrictive assumption, we address the deblurring problem of general dynamic scenes which contain multiple moving objects as well as camera shake. In case of dynamic scenes, moving objects and background have different blur motions, so the segmentation of the motion blur is required for deblurring each distinct blur motion ac

Computer Vision and Pattern RecognitionComputer Science
6
논문|인용수 191·2010
Pathologic Complete Response of Primary Tumor Following Preoperative Chemoradiotherapy for Locally Advanced Rectal Cancer
Seung‐Gu Yeo, Dae Yong Kim, Tae Hyun Kim, Hee Jin Chang, Jae Hwan Oh, Won Park, Doo Ho Choi, Heerim Nam, Jun-Sang Kim, Moon-June Cho, Jong Hoon Kim, Jin‐hong Park
SJR Q1FWCI 7.3Annals of SurgeryOA

LARC patients achieving ypT0N0 after preoperative CRT had favorable long-term outcomes, whereas positive ypN status had a poor prognosis even after total regression of primary tumor.

OncologyMedicine
7
논문|인용수 172·2006
Dose–volumetric parameters predicting radiation-induced hepatic toxicity in unresectable hepatocellular carcinoma patients treated with three-dimensional conformal radiotherapy
Tae Hyun Kim, Dae Yong Kim, Joong‐Won Park, Seong Hoon Kim, Joon‐Il Choi, Hyun Beom Kim, Woo Jin Lee, Sang‐Jae Park, Eun Kyung Hong, Chang‐Min Kim
SJR Q1FWCI 4.5International Journal of Radiation Oncology*Biology*Physics
RadiationPhysics and Astronomy
8
논문|인용수 167·2008
Single‐Carbon‐Atomic‐Resolution Detection of Odorant Molecules using a Human Olfactory Receptor‐based Bioelectronic Nose
Tae Hyun Kim, Sang Hun Lee, Joohyung Lee, Hyun Seok Song, Eun Hae Oh, Tai Hyun Park, Seunghun Hong
SJR Q1FWCI 3.2Advanced Materials

Single-carbon-atomic-resolution detection of odorant molecules has been demonstrated using a human olfactory receptor-based bioelectric nose. Furthermore, since the human olfactory receptor is a G-protein-coupled receptor (GPCR), these sensor systems may be a new powerful platform for the development of new drugs and fragrances.

Sensory SystemsNeuroscience
9
논문|인용수 163·2015
Generalized video deblurring for dynamic scenes
Tae Hyun Kim, Kyoung Mu Lee
FWCI 6.0

Several state-of-the-art video deblurring methods are based on a strong assumption that the captured scenes are static. These methods fail to deblur blurry videos in dynamic scenes. We propose a video deblurring method to deal with general blurs inherent in dynamic scenes, contrary to other methods. To handle locally varying and general blurs caused by various sources, such as camera shake, moving objects, and depth variation in a scene, we approximate pixel-wise kernel with bidirectional optica

Computer Vision and Pattern RecognitionComputer Science
10
논문|인용수 153·2011
Selective and Sensitive TNT Sensors Using Biomimetic Polydiacetylene-Coated CNT-FETs
Tae Hyun Kim, Byung Yang Lee, Justyn Jaworski, Keisuke Yokoyama, Woo-Jae Chung, Eddie Wang, Seunghun Hong, Arun Majumdar, Seung‐Wuk Lee
SJR Q1FWCI 6.3ACS Nano

Miniaturized smart sensors that can perform sensitive and selective real-time monitoring of target analytes are tremendously valuable for various sensing applications. We developed selective nanocoatings by combining trinitrotoluene (TNT) receptors bound to conjugated polydiacetylene (PDA) polymers with single-walled carbon nanotube field-effect transistors (SWNT-FET). Selective binding events between the TNT molecules and phage display derived TNT receptors were effectively transduced to sensit

Organic ChemistryChemistry
11
논문|인용수 143·2005
Dose-volumetric Parameters for Predicting Severe Radiation Pneumonitis after Three-dimensional Conformal Radiation Therapy for Lung Cancer
Tae Hyun Kim, Kwan Ho Cho, Hong Ryull Pyo, Jin Soo Lee, Jae Ill Zo, Dae Ho Lee, Jong Mog Lee, Hyae Young Kim, Bin Hwangbo, Sung Yong Park, Joo Young Kim, Kyung Hwan Shin
SJR Q1FWCI 8.3Radiology

MLD is a useful indicator of risk for development of severe RP after 3D conformal radiation therapy in patients with lung cancer.

RadiationPhysics and Astronomy
12
논문|인용수 116·2006
Three-Dimensional Conformal Radiotherapy of Unresectable Hepatocellular Carcinoma Patients for Whom Transcatheter Arterial Chemoembolization Was Ineffective or Unsuitable
Tae Hyun Kim, Dae Yong Kim, Joong‐Won Park, Young‐Il Kim, Seong Hoon Kim, Hong Suk Park, Woo Jin Lee, Sang‐Jae Park, Eun Kyung Hong, Chang‐Min Kim
SJR Q3FWCI 3.6American Journal of Clinical Oncology

3D-CRT was associated with a 54.3% objective response rate for primary tumors and a 39.0% objective response rate for PVT. Both primary tumor and PVT responses were found to be prognostic factors for overall survival. The present results suggest 3D-CRT is a practical treatment option in HCC patients for whom TACE is ineffective or unsuitable.

HepatologyMedicine
13
논문|인용수 108·2017
One-Step Electrochemical Fabrication of Reduced Graphene Oxide/Gold Nanoparticles Nanocomposite-Modified Electrode for Simultaneous Detection of Dopamine, Ascorbic Acid, and Uric Acid
Chang‐Seuk Lee, Su Yu, Tae Hyun Kim
SJR Q1FWCI 6.4NanomaterialsOA

Here, we introduce the preparation of the hybrid nanocomposite-modified electrode consisting of reduced graphene oxide (RGO) and gold nanoparticles (AuNPs) using the one-step electrochemical method, allowing for the simultaneous and individual detection of dopamine (DA), ascorbic acid (AA), and uric acid (UA). RGO/AuNPs nanocomposite was formed on a glassy carbon electrode by the co-reduction of GO and Au<sup>3+</sup> using the potentiodynamic method. The RGO/AuNPs nanocomposite-modified electro

Electrical and Electronic EngineeringEngineering
14
논문|인용수 108·2012
Phase 3 Trial of Postoperative Chemotherapy Alone Versus Chemoradiation Therapy in Stage III-IV Gastric Cancer Treated With R0 Gastrectomy and D2 Lymph Node Dissection
Tae Hyun Kim, Sook Ryun Park, Keun Won Ryu, Young‐Woo Kim, Jae-Moon Bae, Jun Ho Lee, Il Ju Choi, Yeon-Joo Kim, Dae Yong Kim
SJR Q1FWCI 9.0International Journal of Radiation Oncology*Biology*Physics
Pulmonary and Respiratory MedicineMedicine
15
논문|인용수 101·2017
Doxorubicin-loaded oligonucleotide conjugated gold nanoparticles: A promising in vivo drug delivery system for colorectal cancer therapy
Chang‐Seuk Lee, Hyungjoo Kim, Joonhee Yu, Su Yu, Seona Ban, Seunghyun Oh, Dongjun Jeong, Jungkyun Im, Moo Jun Baek, Tae Hyun Kim
SJR Q1FWCI 4.3European Journal of Medicinal Chemistry
Molecular BiologyBiochemistry, Genetics and Molecular Biology

대표 연구 분야

OncologyMolecular BiologyHepatologySurgeryPulmonary and Respiratory MedicineElectrical and Electronic Engineering

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