김태현 교수
Tae Hyun Kim
서울대학교 · 의학
연구실 소개
김태현 교수의 연구실은 나노소재의 생체안정성과 세포 독성 메커니즘을 중심으로, 특히 은 나노입자( AgNPs )의 크기별 세포 독성 영향을 체계적으로 분석하고 있습니다. 동시에 영상 복원 기술 분야에서도 동적 환경에서 발생하는 다양한 블러(카메라 흔들림, 다중 운동 객체 등)를 정밀하게 복원할 수 있는 신호 처리 기반의 혁신적 알고리즘을 개발하고 있습니다. 특히 운동 세분화 없이도 국소적으로 변화하는 블러를 처리할 수 있는 에너지 최적화 모델과 광학 흐름 기반 영상 복원 기법을 핵심으로 연구를 전개하고 있습니다. 또한 생물학적 수용체를 기반으로 한 고해상도 냄새 감지 센서 기술을 통해 바이오센서와 신약 개발 플랫폼의 가능성도 탐색하고 있습니다.
연구 현황
연구 성과 추이
표시된 성과는 수집된 데이터 기준으로 산출되며, 일부 차이가 있을 수 있습니다.
주요 논문
15Silver nanoparticles (AgNPs) have found a variety of uses including biomedical materials; however, studies of the cytotoxicity of AgNPs by size effects are only in the beginning stage. In this study, we examined the size-dependent cellular toxicity of AgNPs using three different characteristic sizes (∼ 10, 50, and 100 nm) against several cell lines including MC3T3-E1 and PC12. The cytotoxic effect determined based on the cell viability, intracellular reactive oxygen species generation, lactate d
Most state-of-the-art dynamic scene deblurring methods based on accurate motion segmentation assume that motion blur is small or that the specific type of motion causing the blur is known. In this paper, we study a motion segmentation-free dynamic scene deblurring method, which is unlike other conventional methods. When the motion can be approximated to linear motion that is locally (pixel-wise) varying, we can handle various types of blur caused by camera shake, including out-of-plane motion, d
Most conventional single image deblurring methods assume that the underlying scene is static and the blur is caused by only camera shake. In this paper, in contrast to this restrictive assumption, we address the deblurring problem of general dynamic scenes which contain multiple moving objects as well as camera shake. In case of dynamic scenes, moving objects and background have different blur motions, so the segmentation of the motion blur is required for deblurring each distinct blur motion ac
LARC patients achieving ypT0N0 after preoperative CRT had favorable long-term outcomes, whereas positive ypN status had a poor prognosis even after total regression of primary tumor.
Single-carbon-atomic-resolution detection of odorant molecules has been demonstrated using a human olfactory receptor-based bioelectric nose. Furthermore, since the human olfactory receptor is a G-protein-coupled receptor (GPCR), these sensor systems may be a new powerful platform for the development of new drugs and fragrances.
Several state-of-the-art video deblurring methods are based on a strong assumption that the captured scenes are static. These methods fail to deblur blurry videos in dynamic scenes. We propose a video deblurring method to deal with general blurs inherent in dynamic scenes, contrary to other methods. To handle locally varying and general blurs caused by various sources, such as camera shake, moving objects, and depth variation in a scene, we approximate pixel-wise kernel with bidirectional optica
Miniaturized smart sensors that can perform sensitive and selective real-time monitoring of target analytes are tremendously valuable for various sensing applications. We developed selective nanocoatings by combining trinitrotoluene (TNT) receptors bound to conjugated polydiacetylene (PDA) polymers with single-walled carbon nanotube field-effect transistors (SWNT-FET). Selective binding events between the TNT molecules and phage display derived TNT receptors were effectively transduced to sensit
MLD is a useful indicator of risk for development of severe RP after 3D conformal radiation therapy in patients with lung cancer.
3D-CRT was associated with a 54.3% objective response rate for primary tumors and a 39.0% objective response rate for PVT. Both primary tumor and PVT responses were found to be prognostic factors for overall survival. The present results suggest 3D-CRT is a practical treatment option in HCC patients for whom TACE is ineffective or unsuitable.
Here, we introduce the preparation of the hybrid nanocomposite-modified electrode consisting of reduced graphene oxide (RGO) and gold nanoparticles (AuNPs) using the one-step electrochemical method, allowing for the simultaneous and individual detection of dopamine (DA), ascorbic acid (AA), and uric acid (UA). RGO/AuNPs nanocomposite was formed on a glassy carbon electrode by the co-reduction of GO and Au<sup>3+</sup> using the potentiodynamic method. The RGO/AuNPs nanocomposite-modified electro
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