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장원일 교수

Won Il Jang

서울대학교 · 의학

연구실 소개

장원일 교수의 연구실은 간세포생식성암(HCC)과 췌장암을 중심으로 한 암 치료 전략 개발에 초점을 맞추고 있습니다. 특히 입방선비침습적방사선치료(SBRT)와 메트포르민의 암세포 억제 효과, 그리고 커큐민 등 천연물질이 방사선 치료에 어떻게 작용하는지를 기반으로 한 표적 치료 전략을 연구하고 있습니다. 뇌종양인 거대세포성신경아교세포종의 치료 내성 문제 해결을 위한 약물 조합 기반의 신규 치료법 개발도 진행 중입니다. 이는 임상적 적용이 가능한 맞춤형 암 치료의 실현을 목표로 하고 있습니다.

간세포생식성암메트포르민SBRT방사선 치료천연물질

연구 현황

논문 수
118
총 인용 수
1,618
최근 5년 논문
52
주요 분야
의학

연구 성과 추이

표시된 성과는 수집된 데이터 기준으로 산출되며, 일부 차이가 있을 수 있습니다.

5개년 연도별 논문 게재 수
52총합
2022
2023
2024
2025
2026
5개년 연도별 피인용 수
301총합
20222023202420252026

주요 논문

15
1
논문|인용수 226·2013
High-dose stereotactic body radiotherapy correlates increased local control and overall survival in patients with inoperable hepatocellular carcinoma
Won Il Jang, Mi‐Sook Kim, Sun Hyun Bae, Chul Koo Cho, Hyung Jun Yoo, Young Seok Seo, Jin-Kyu Kang, So Young Kim, Dong Han Lee, Chul Ju Han, Jin Kim, Su Cheol Park
SJR Q1FWCI 7.6Radiation OncologyOA

This study demonstrated a dose response relationship for LC and OS with SBRT for HCC. Higher LC rates resulting from an increased dose may translate into survival benefits for patients with HCC.

HepatologyMedicine
2
논문|인용수 115·2019
A phase 2 multicenter study of stereotactic body radiotherapy for hepatocellular carcinoma: Safety and efficacy
Won Il Jang, Sun Hyun Bae, Mi‐Sook Kim, Chul Ju Han, Su Cheol Park, Sang Bum Kim, Eung‐Ho Cho, Chul Won Choi, Kyung Su Kim, Sangyoun Hwang, Jin Ho Kim, Ah Ram Chang
SJR Q1FWCI 7.6Cancer

With a median follow-up of 41 months, this prospective multicenter study demonstrated that SBRT for patients with HCC is well tolerated and is an effective treatment modality.

HepatologyMedicine
3
논문|인용수 92·2012
Mid-term results of bioprosthetic pulmonary valve replacement in pulmonary regurgitation after tetralogy of Fallot repair
Won Il Jang, Yoon Jung Kim, Kwang‐Ho Choi, Hong‐Gook Lim, Won Ho Kim, Jin Lee
SJR Q1FWCI 4.3European Journal of Cardio-Thoracic SurgeryOA

PVR reduced the RV volume and improved the RV function within the first postoperative year. The rate of freedom from reoperation during the 10-year follow-up period in our series was acceptable. However, a longer follow-up will be necessary to determine the long-term outcomes of bioprosthetic valves in PVR.

EpidemiologyMedicine
4
논문|인용수 40·2017
Association between metformin use and mortality in patients with type 2 diabetes mellitus and localized resectable pancreatic cancer: a nationwide population-based study in korea
Won Il Jang, Mi‐Sook Kim, Shin Hee Kang, Ae Jung Jo, Yun Jung Kim, Ha Jin Tchoe, Chan Mi Park, Hyo Jeong Kim, Jin A Choi, Hyung Jin Choi, Eun-Kyung Paik, Young Seok Seo
SJR Q2FWCI 3.3OncotargetOA

This large study indicates that metformin might decrease cancer-specific mortality rates in localized resectable pancreatic cancer patients with pre-existing diabetes, independently of other factors, with a dose-response relationship.

OncologyMedicine
5
논문|인용수 38·2015
Survival Advantage Associated with Metformin Usage in Hepatocellular Carcinoma Patients Receiving Radiotherapy: A Propensity Score Matching Analysis.
Won Il Jang, Mi‐Sook Kim, Jung Sub Lim, Hyung Jun Yoo, Young Seok Seo, Chul Ju Han, Su Cheol Park, Chul Seung Kay, Myungsoo Kim, Hong Seok Jang, Dong Soo Lee, Ah Ram Chang
FWCI 0.9PubMed

The use of metformin in patients with hepatocellular carcinoma receiving radiotherapy was associated with higher overall survival.

Molecular BiologyBiochemistry, Genetics and Molecular Biology
6
논문|인용수 15·2022
Interaction of curcumin with glioblastoma cells via high and low linear energy transfer radiation therapy inducing radiosensitization effects
Jeong‐Yub Kim, Chan‐Woong Jung, Won Seok Lee, Hee‐Jin Kim, Hyeon-Jeong Jeong, Myung‐Jin Park, Won Il Jang, Eun Ho Kim
SJR Q2FWCI 1.2Journal of Radiation ResearchOA

Glioblastoma is a deadly cancer tumor in the brain and has a survival rate of about 15 months. Despite the high mortality rate, temozolomide has proven to increase the survival rate of patients when combined with radiotherapy. However, its effects may be limited because some patients develop therapeutic resistance. Curcumin has proven to be a cancer treatment due to its broad anticancer spectrum, high efficiency and low toxic level. Additionally, curcumin significantly enhanced radiation efficac

Biomedical EngineeringEngineering
7
논문|인용수 14·2010
Transient Left Ventricular Systolic Dysfunction Associated with Carbon Monoxide Toxicity
Won Il Jang, Jae‐Hyeong Park
FWCI 0.7Journal of Cardiovascular UltrasoundOA

Carbon monoxide (CO) is one of well known chemical asphyxiants which cause tissue hypoxia with prominent neurologic and cardiovascular injury. Cardiac dysfunction after CO poisoning can be presented as two clinical patterns. One is transient global left ventricular (LV) dysfunction and the other is LV dysfunction with regional wall motion abnormalities. In this case report, we present a case with transient LV systolic dysfunction caused by intentional exposure to CO. After conservative treatment

Molecular BiologyBiochemistry, Genetics and Molecular Biology
8
리뷰|인용수 12·2023
The Current Evidence of Intensity-Modulated Radiotherapy for Hepatocellular Carcinoma: A Systematic Review and Meta-Analysis
Won Il Jang, Sunmi Jo, Ji Eun Moon, Sun Hyun Bae, Hee Chul Park
SJR Q1FWCI 2.4CancersOA

Intensity-modulated radiotherapy (IMRT), an advanced RT technique, is a considerable treatment option for hepatocellular carcinoma (HCC). However, the distinguishing features of IMRT for HCC have not yet been clearly defined. A systematic review was performed according to the guidelines of the Preferred Reporting Items for Systematic Reviews and Meta-Analyses. The PubMed/MedLine, Embase, Cochrane Library, Web of Science, and KoreaMed were used to screen eligible studies focusing on treatment out

HepatologyMedicine
9
논문|인용수 12·2020
Clinical utilization of radiation therapy in Korea, 2016
Eunji Kim, Won Il Jang, Mi‐Sook Kim, Eun Kyung Paik, Han Jo Kim, Hyung Jun Yoo, Kwangmo Yang, Chul Koo Cho
SJR Q2FWCI 2.1Journal of Radiation ResearchOA

Radiotherapy (RT) is one of the primary cancer treatment modalities. To estimate the actual utilization of RT and infrastructure in Korea, the current study was performed. Data from 2012 to 2016 were extracted from the Health Insurance Review and Assessment Service. In addition, a nationwide survey was conducted to collect the statistics of RT facilities, equipment and human resources in Korea. The total number of patients treated with RT was 72 563 in 2016. The five cancers that were most commo

RadiationPhysics and Astronomy
10
논문|인용수 11·2012
Definitive Radiotherapy for Treatment of Primary Vaginal Cancer
Won Il Jang, Hong‐Gyun Wu, Sung Whan Ha, Hak Jae Kim, Soon Beom Kang, Yong Sang Song, Noh-Hyun Park, Jae‐Weon Kim
SJR Q1FWCI 1.5International Journal of Gynecological Cancer
Obstetrics and GynecologyMedicine
11
논문|인용수 8·2010
A Successful Primary Percutaneous Coronary Intervention Twelve Days After a Cabrol Composite Graft Operation in Marfan Syndrome
Won Il Jang, Jin‐Ok Jeong, Kye-Taek Ahn, Hyung Seo Park, Jae‐Hyeong Park, Song Soo Kim, Jae‐Hwan Lee, Si Wan Choi, In Whan Seong
SJR Q2Korean Circulation JournalOA

The Cabrol procedure is one of several techniques used for re-implantation of a coronary artery. After replacement of the ascending aorta and aortic valve using a composite graft, second Dacron tube grafts are used for anastomosis between the ascending aortic graft and the coronary arteries. Ostial stenosis is one of the complications associated with the Cabrol operation. However, there have been no reported cases of acute thrombosis of a Cabrol graft. Here we report a case with acute ST elevati

Pulmonary and Respiratory MedicineMedicine
12
논문|인용수 7·2004
Effect of Depletion Force on the Stability of Food Emulsions
Won Il Jang, Alex Nikolov, D. T. Wasan
SJR Q3FWCI 0.5Journal of Dispersion Science and Technology

Abstract The stability of food emulsions containing milk proteins and sucrose ester was studied by measuring the creaming velocity of an oil‐in‐water emulsion. The inter‐droplet interaction was quantified by measuring the radial distribution function using an advanced digital imaging technique. The phenomenon of protein sub‐micelles layering inside the film formed between the adjacent droplets was observed by using the capillary force balance apparatus. The attractive interaction of the droplets

Food ScienceAgricultural and Biological Sciences
13
논문|인용수 6·2004
Effect of Protein on the Texture of Food Emulsions under Steady Flow
Won Il Jang, Alex Nikolov, Darsh T. Wasan, K. Chen, Bruce Campbell
SJR Q1FWCI 0.5Industrial & Engineering Chemistry Research

The texture of food emulsions was quantified as the structure factor using the backlight scattering technique. The change of the texture of food emulsions under steady flow was monitored in terms of the structure factor. The role of different types of protein (sodium caseinate and soy protein) on the change of texture of food emulsions under steady flow was studied. The emulsion stabilized by sodium caseinate was more stable under steady flow than the food emulsion stabilized by FP940 (partially

Food ScienceAgricultural and Biological Sciences
14
논문|인용수 4·2022
Emodin coupled with high LET neutron beam—a novel approach to treat on glioblastoma
Jeong‐Yub Kim, Chan‐Woong Jung, Won Seok Lee, Hyeon-Jeong Jeong, Myung‐Jin Park, Won Il Jang, Eun Ho Kim
SJR Q2FWCI 0.8Journal of Radiation ResearchOA

The primary motivation of this investigative study is trying to find an alternative treatment that can be used to slow down or treat glioblastoma due to the witnessed toxic side effects of the current drugs coupled with limited effectiveness in overall treatment. Consequently, a Chinese plant extract emodin proves to play a critical role in this investigative study since results from the Western blot and the other accompanying assays for anti-cancer effects indicate that it cannot work a lot to

Plant ScienceAgricultural and Biological Sciences
15
논문|인용수 2·2022
Enhancement of Radiation Response Associated With Metformin in Hepatocellular Carcinoma: Preclinical Animal and Clinical Cohort Study
Won Il Jang, Mi‐Sook Kim, Jae‐Hoon Jeong, Wonwoo Kim, Kim Js
SJR Q2FWCI 0.2Anticancer ResearchOA

Background/Aim: This study examined whether metformin can enhance the radiation response in a hepatocellular carcinoma (HCC) xenograft mice model and patient population. Materials and Methods: Huh-7 human HCC-bearing xenograft mice were treated with gamma-ray, metformin, neutron therapy, and their combinations. Tumour growth and lung colonies were assessed. Overall, 145 patients who underwent radiotherapy for HCC were retrospectively analysed. Results: The combinations of gamma-ray and metformin

Molecular BiologyBiochemistry, Genetics and Molecular Biology

대표 연구 분야

Radiology, Nuclear Medicine and ImagingHepatologyPulmonary and Respiratory MedicineRadiationSurgeryMolecular Biology

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