임예지 교수
Yejee Lim
서울대학교 · 의학
연구실 소개
임예지 교수의 연구실은 산화 스트레스와 DNA 손상, 특히 8-옥시구아닌 관련 복합 메커니즘을 중심으로 암 유발 메커니즘을 규명하는 데 초점을 맞추고 있습니다. 특히 섬유질 미세먼지인 아스ベスト이 유전자에 미치는 영향과 그 복구 기전을 분석하며, 산화적 손상과 관련된 효소 및 유전자 발현 변화를 고성능 분석 기법을 통해 연구하고 있습니다. 또한, 임상적 응용 분야로는 심혈관계 질환 예방을 위한 약물 전처리 효과나, 노인 환자 대상의 스마트 기반 간병 기술 개발 등 실용적 의료 기술의 발전에도 기여하고 있습니다.
연구 현황
연구 성과 추이
표시된 성과는 수집된 데이터 기준으로 산출되며, 일부 차이가 있을 수 있습니다.
주요 논문
15We examined 8-hydroxyguanine (8-OH-Gua) formation and 8-OH-Gua repair enzyme activity in pulmonary type-II-like epithelial cells to determine whether oxidative stress induced by asbestos plays a role in its carcinogenic mechanism. A549 cells were incubated with crocidolite asbestos at concentrations of 0, 10, 50 and 100 microg/ml over 27 h. We then evaluated 8-OH-Gua formation, 8-OH-Gua repair enzyme activity and gene expression of 8-oxoguanine-DNA glycosylase 1 (hOGG1) and human MUtT homologue
Pretreatment with 50 microg of adenosine decreases the incidence of myonecrosis after non-urgent PCI compared with that without pretreatment.
The smart diaper system showed acceptable accuracy for measuring urine volume and it could replace conventional FVCs in acute setting hospitals. Furthermore, the smart diaper system has the potential advantage of preventing IAD development and bed sore worsening. However, the detection rate of the smart diaper system was lower than expected. Detection rate polarization among participants was observed, and improvements in the user interface and convenience are needed for older individuals who are
Intraperitoneal drain placement after elective colorectal surgery is not associated with earlier detection of postoperative collections, but prolongs hospital stay and increases SSI risk.
Background: No consensus exists regarding the early use of subcutaneous (SC) basal insulin facilitating the transition from continuous intravenous insulin infusion (CIII) to multiple SC insulin injections in patients with severe hyperglycemia other than diabetic ketoacidosis. This study evaluated the effect of early co-administration of SC basal insulin with CIII on glucose control in patients with severe hyperglycemia.Methods: Patients who received CIII for the management of severe hyperglycemi
An inverse association between coffee consumption and the risk of diabetes mellitus (DM) has been observed. However, little is known about this association in Koreans, although they are now among the top global consumers of coffee. Therefore, the aim of this study was to evaluate the association between the prevalence of DM and the amount of coffee consumption using a unit of exact measurement, regardless of the type of coffee consumed. This study was based on data acquired from the Korea Nation
This paper considers a problem of variable selection in quantile regression with autoregressiveerrors. Recently, Wu and Liu (2009) investigated the oracle properties of the SCADand adaptive-LASSO penalized quantile regressions under non identical but independenterror assumption. We further relax the error assumptions so that the regression modelcan hold autoregressive errors, and then investigate theoretical properties for our proposedpenalized quantile estimators under the relaxed assumption. O
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