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김영우 교수

Youngwoon Lee

서울대학교 · 의학

연구실 소개

김영우 교수의 연구실은 위상적 암 생물학과 신약 타겟 발견을 중심으로, 간암의 대사 전환 메커니즘과 관련된 핵심 신호전달 경로를 규명하고 있습니다. 특히 AMPK-α/HNF4α/WNT5A 신호 경로를 통해 암세포의 대사 재편성을 조절하는 온코프로테인의 기능을 밝혀내고 있으며, 이는 새로운 약물 타겟으로서의 잠재력을 지닙니다. 또한, 자연물 유래 화합물(예: d-리모넨, 플라보노이드)의 생리활성과 약리적 기전에 대한 기초 연구를 병행하고 있습니다. 이와 더불어 리튬이온 배터리의 고용량 음극재로 활용 가능한 테이퍼형 스테인리스 인산화물의 합성 및 전기화학적 특성 연구도 수행하고 있습니다.

암 대사 전환신약 타겟 발견플라보노이드리모넨 유도체고용량 음극재

연구 현황

논문 수
418
총 인용 수
24,377
최근 5년 논문
73
주요 분야
의학

연구 성과 추이

표시된 성과는 수집된 데이터 기준으로 산출되며, 일부 차이가 있을 수 있습니다.

5개년 연도별 논문 게재 수
73총합
2020
2021
2022
2023
2024
5개년 연도별 피인용 수
3,101총합
20202021202220232024

주요 논문

15
1
논문|인용수 607·2008
Improved Quality of Life Outcomes After Laparoscopy-Assisted Distal Gastrectomy for Early Gastric Cancer
Young‐Woo Kim, Yong Hae Baik, Young Ho Yun, Byung Ho Nam, Dae‐Hyun Kim, Il Ju Choi, Jae-Moon Bae
SJR Q1FWCI 23.3Annals of Surgery

Comparison of LADG to ODG in patients with early gastric cancer resulted in improved QOL outcomes in the patients followed for up to 3 months in the LADG group.

Pulmonary and Respiratory MedicineMedicine
2
리뷰|인용수 207·2013
Safety Evaluation And Risk Assessment Of<i>d</i>-Limonene
Young Woo Kim, Min Ji Kim, Bu Young Chung, Du Yeon Bang, Seong Kwang Lim, Seul Min Choi, Duck Soo Lim, Myung Chan Cho, Kyungsil Yoon, Hyung Sik Kim, Kyu‐Bong Kim, You Sun Kim
SJR Q1FWCI 16.2Journal of Toxicology and Environmental Health Part B

d-Limonene, a major constituent of citrus oils, is a monoterpene widely used as a flavor/fragrance additive in cosmetics, foods, and industrial solvents as it possesses a pleasant lemon-like odor. d-Limonene has been designated as a chemical with low toxicity based upon lethal dose (LD50) and repeated-dose toxicity studies when administered orally to animals. However, skin irritation or sensitizing potential was reported following widespread use of this agent in various consumer products. In exp

Plant ScienceAgricultural and Biological Sciences
3
논문|인용수 145·2013
Long-term outcomes of laparoscopy-assisted distal gastrectomy for early gastric cancer: result of a randomized controlled trial (COACT 0301)
Young‐Woo Kim, Hong Man Yoon, Young Ho Yun, Byung Ho Nam, Bang Wool Eom, Yong Hae Baik, Sang Eok Lee, Ye-Ji Lee, Young‐Ae Kim, Ji Yeon Park, Keun Won Ryu
SJR Q1FWCI 9.0Surgical Endoscopy
Pulmonary and Respiratory MedicineMedicine
4
논문|인용수 117·2006
Liquiritigenin, an aglycone of liquiritin in Glycyrrhizae radix, prevents acute liver injuries in rats induced by acetaminophen with or without buthionine sulfoximine
Young Woo Kim, Sung Hwan Ki, Jong Rok Lee, Song Jin Lee, Choon Won Kim, Sang Chan Kim, Sang Geon Kim
SJR Q1FWCI 7.4Chemico-Biological Interactions
PharmacologyPharmacology, Toxicology and Pharmaceutics
5
논문|인용수 116·2014
HNF4α is a therapeutic target that links AMPK to WNT signalling in early-stage gastric cancer
Hae Ryung Chang, Seungyoon Nam, Myeong‐Cherl Kook, Kyung-Tae Kim, Xiuping Liu, Hui Yao, Hae Rim Jung, Robert Lemos, Hye Hyun Seo, Hee Seo Park, Youme Gim, Dongwan Hong
SJR Q1FWCI 3.8GutOA

Our results indicate that HNF4α is a targetable oncoprotein in GC, is regulated by AMPK signalling through AMPKα and resides upstream of WNT signalling. HNF4α may regulate 'metabolic switch' characteristic of a general malignant phenotype and its target WNT5A has potential prognostic values. The AMPKα-HNF4α-WNT5A signalling cascade represents a potentially targetable pathway for drug development.

Molecular BiologyBiochemistry, Genetics and Molecular Biology
6
논문|인용수 105·2009
Efficacy of sauchinone as a novel AMPK-activating lignan for preventing iron-induced oxidative stress and liver injury
Young Woo Kim, Sung Min Lee, Sang Mi Shin, Se Jin Hwang, Janie S. Brooks, Hee Eun Kang, Myung Gull Lee, Sang Chan Kim, Sang Geon Kim, Sang Geon Kim, Sang Geon Kim
SJR Q1FWCI 3.1Free Radical Biology and Medicine
Molecular BiologyBiochemistry, Genetics and Molecular Biology
7
논문|인용수 104·2007
Reversible Lithium Intercalation in Teardrop‐Shaped Ultrafine SnP<sub>0.94</sub> Particles: An Anode Material for Lithium‐Ion Batteries
Young‐Woo Kim, H. L. Hwang, Chong Seung Yoon, Min Gyu Kim, Jaehun Cho
SJR Q1FWCI 5.7Advanced Materials

Uniformly dispersed teardrop-shaped tin phosphide particles for lithium-ion batteries are synthesized by the reaction of tin acetate in a mixed solution of trioctyl phosphine (TOP) and trioctylphosphine oxide (TOPO). Reversible intercalation/deintercalation of lithium ions into/from the tin phosphide is found, giving LixSnP0.94 with x up to 3.91 (740 mA h g–1), and little capacity fading between 0 and 1.2 V.

Electrical and Electronic EngineeringEngineering
8
논문|인용수 92·2015
Oxyresveratrol abrogates oxidative stress by activating ERK–Nrf2 pathway in the liver
Hee Yoon Choi, Ju‐Hee Lee, Kyung Hwan Jegal, Il Je Cho, Young Woo Kim, Sang Chan Kim
SJR Q1FWCI 4.1Chemico-Biological Interactions
Molecular BiologyBiochemistry, Genetics and Molecular Biology
9
논문|인용수 89·2004
Synthesis and Aromatase Inhibitory Activity of Novel Pyridine-Containing Isoflavones
Young Woo Kim, John C. Hackett, Robert W. Brueggemeier
SJR Q1FWCI 4.3Journal of Medicinal ChemistryOA

Aromatase, a cytochrome P450 hemoprotein that is responsible for estrogen biosynthesis by conversion of androgens into estrogens, has been an attractive target in the treatment of hormone-dependent breast cancer. As a result, a number of synthetic steroidal or nonsteroidal aromatase inhibitors have been successfully developed. In addition, there are several classes of natural products that exert potent activities in aromatase inhibition, with the flavonoids being most prominent. Previous studies

GeneticsBiochemistry, Genetics and Molecular Biology
10
논문|인용수 89·2014
AMPK activation by isorhamnetin protects hepatocytes against oxidative stress and mitochondrial dysfunction
Guang-zhi Dong, Ju‐Hee Lee, Sung Hwan Ki, Ji Hye Yang, Il Je Cho, Seung Ho Kang, Rongjie Zhao, Sang Chan Kim, Young Woo Kim
SJR Q1FWCI 6.2European Journal of Pharmacology
Endocrinology, Diabetes and MetabolismMedicine
11
논문|인용수 87·2017
Effect of Intravenous Ferric Carboxymaltose on Hemoglobin Response Among Patients With Acute Isovolemic Anemia Following Gastrectomy
Young‐Woo Kim, Jae-Moon Bae, Young Kyu Park, Han‐Kwang Yang, Wansik Yu, Jeong Hwan Yook, Sung Hoon Noh, Mira Han, Keun Won Ryu, Tae Sung Sohn, Hyuk‐Joon Lee, Oh Kyoung Kwon
SJR Q1FWCI 7.2JAMAOA

clinicaltrials.gov Identifier: NCT01725789.

HematologyMedicine
12
논문|인용수 84·2009
Inhibition of SREBP-1c-mediated hepatic steatosis and oxidative stress by sauchinone, an AMPK-activating lignan in Saururus chinensis
Young Woo Kim, Young Mi Kim, Yoon Mee Yang, Tae Hyun Kim, Se Jin Hwang, Jong Rok Lee, Sang Chan Kim, Sang Geon Kim
SJR Q1FWCI 4.5Free Radical Biology and Medicine
BiochemistryBiochemistry, Genetics and Molecular Biology
13
논문|인용수 75·2010
Prognostic Value of Preoperative Clinical Staging Assessed by Computed Tomography in Resectable Gastric Cancer Patients
Sook Ryun Park, Min Ju Kim, Keun Won Ryu, Jun Ho Lee, Jong Seok Lee, Byung‐Ho Nam, Il Ju Choi, Young‐Woo Kim
SJR Q1FWCI 4.6Annals of Surgery

Clinical stage is an independent predictor of long-term survival in the preoperative setting. It should be incorporated as a stratification factor in a randomized clinical trial of preoperative therapy for gastric cancer patients.

Pulmonary and Respiratory MedicineMedicine
14
논문|인용수 73·2015
Role of robot-assisted distal gastrectomy compared to laparoscopy-assisted distal gastrectomy in suprapancreatic nodal dissection for gastric cancer
Young‐Woo Kim, Daniel Reim, Ji Yeon Park, Bang Wool Eom, Myeong‐Cherl Kook, Keun Won Ryu, Hong Man Yoon
SJR Q1FWCI 4.5Surgical Endoscopy
Pulmonary and Respiratory MedicineMedicine
15
논문|인용수 68·2008
Free-Hand Pedicle Screw Placement During Revision Spinal Surgery
Young‐Woo Kim, Lawrence G. Lenke, Yongjung J. Kim, Keith H. Bridwell, Youngbae B. Kim, Kei Watanabe, Kota Watanabe
SJR Q1FWCI 3.7Spine

: The free-hand technique of thoracic and lumbosacral pedicle screw placement in revision spinal surgery is reliable and safe when using the quadrangulation method of gaining pedicle access in a prior fusion mass or at pseudarthrosis levels.

SurgeryMedicine

대표 연구 분야

Pulmonary and Respiratory MedicineSurgeryMolecular BiologyOncologyPharmacologyPathology and Forensic Medicine

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