東京大学 · 生化学・遺伝学・分子生物学
Alok Sharma教授の研究室は、ゲノムデータや脳波信号を含む高次元で複雑なオミックスデータの解析に、深層学習とコンvolutionニューラルネットワークを応用した新規解析手法の開発を主眼としています。特に、非画像データを画像に変換する「DeepInsight」のようなアプローチにより、遺伝子のクラスターや脳波パターンの微細な差を効果的に抽出し、疾患のメカニズム解明や脳・コンピュータインターフェースの高精度分類を実現しています。臨床応用に向けたリアルタイムかつ高精度な予測モデル構築が、研究の核となっています。
Figures are computed from collected data and may differ slightly.
It is critical, but difficult, to catch the small variation in genomic or other kinds of data that differentiates phenotypes or categories. A plethora of data is available, but the information from its genes or elements is spread over arbitrarily, making it challenging to extract relevant details for identification. However, an arrangement of similar genes into clusters makes these differences more accessible and allows for robust identification of hidden mechanisms (e.g. pathways) than dealing
The field of omics, driven by advances in high-throughput sequencing, faces a data explosion. This abundance of data offers unprecedented opportunities for predictive modeling in precision medicine, but also presents formidable challenges in data analysis and interpretation. Traditional machine learning (ML) techniques have been partly successful in generating predictive models for omics analysis but exhibit limitations in handling potential relationships within the data for more accurate predic
Brain-computer interface (BCI) systems having the ability to classify brain waves with greater accuracy are highly desirable. To this end, a number of techniques have been proposed aiming to be able to classify brain waves with high accuracy. However, the ability to classify brain waves and its implementation in real-time is still limited. In this study, we introduce a novel scheme for classifying motor imagery (MI) tasks using electroencephalography (EEG) signal that can be implemented in real-
Supplementary data are available at Bioinformatics online.
Supplementary data are available at Bioinformatics online.
A detailed screening of bacterial isolates from the Central Himalayan region for plant growth promotion and antimycelial activity against Pythium and Phytophthora strains afforded seven isolates, of which three were particularly effective against the incidence of damping-off in field trials on chilli and tomato. In this investigation an initial spectroscopic survey of the methanolic extracts of the seven bacterial isolates showed complex mixtures except for Pseudomonas sp. GRP3, one of the most
Artificial intelligence methods offer exciting new capabilities for the discovery of biological mechanisms from raw data because they are able to detect vastly more complex patterns of association that cannot be captured by classical statistical tests. Among these methods, deep neural networks are currently among the most advanced approaches and, in particular, convolutional neural networks (CNNs) have been shown to perform excellently for a variety of difficult tasks. Despite that applications
These results demonstrate that tyrosine phosphorylation of p130Cas is sufficient for its localization to focal adhesions and for activation of downstream signaling events associated with cell migration. FIT provides a valuable tool to evaluate the contribution of individual components of the response to signals with multiple outputs, such as activation of NTKs.
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