박보람 교수
Boram Park
서울대학교 · 의학
연구실 소개
박보람 교수의 연구실은 주로 의료 및 생물정보학 분야에서 활동하며, 암 환자의 정서적 고통과 신체적 합병증, 특히 우울증, 수면 장애, 심장독성 등의 발생 메커니즘을 유전적 요인과 환경적 요인의 상호작용 관점에서 연구하고 있습니다. 특히 암 종류에 따른 정서적 영향의 이질성, 흡연과 유전적 변이의 상호작용이 폐 기능에 미치는 영향, 그리고 항암치료에 따른 심장독성의 유전적 소인을 밝히는 데 초점을 맞추고 있습니다. 연구는 대규모 임상 데이터와 유전체 분석을 기반으로 하여 임상적 적용 가능성을 고려한 정밀의료 기반 연구를 추구합니다.
연구 현황
연구 성과 추이
표시된 성과는 수집된 데이터 기준으로 산출되며, 일부 차이가 있을 수 있습니다.
주요 논문
15Purpose Upon extending Hoffman and Novak's flow model, this paper aims to delineate the blogging motivations with an emphasis of flow mediation to predict blogging behaviors. Three objectives are to: identify determinant dimensions of blogging motivations, behaviors and flow; investigate the hypothesized relationships between blogging motivations, blogging behaviors with the mediation of flow; and control the moderating effect of individual differences (i.e. blogger and blog reader) to disperse
The prevalence of depression varied according to cancer types. Patients with lung cancer were the most prone to experience depression. Because clinical and psychological factors may influence MDD prevalence, these factors will need to be studied more closely in the future.
Cigarette smoke exposure is a major risk factor in chronic obstructive pulmonary disease (COPD) and its interactions with genetic variants could affect lung function. However, few gene-smoking interactions have been reported. In this report, we evaluated the effects of gene-smoking interactions on lung function using Korea Associated Resource (KARE) data with the spirometric variables-forced expiratory volume in 1 s (FEV<sub>1</sub>). We found that variations in FEV<sub>1</sub> were different am
We performed a genome-wide association study to investigate the association between single nucleotide polymorphisms and anthracycline-induced cardiotoxicity (ACT) in patients diagnosed with early breast cancer. From January 2000 to December 2015, 8490 patients underwent breast surgery at the National Cancer Center in Korea. Patients who received doxorubicin (cumulative dose 240 mg/m<sup>2</sup> -300 mg/m<sup>2</sup> ) with or without trastuzumab as a neoadjuvant/adjuvant therapy were included in
Background and ObjectiveaaThe insomnia rate in cancer patients is nearly three times higher than that in the general population. Due to the distinct and diverse nature of cancer, the prevalence of insomnia is assumed to be affected by differences in primary cancer sites. In this study, we explored the prevalence rates of insomnia among the ten most prevalent cancers in South Korea using a national patient sample. MethodsaaThis was a 1-year cross-sectional study for the year 2011 using a national
The competition graph of a doubly partial order is known to be an interval graph. The CCE graph and the niche graph of a doubly partial order are also known to be interval graphs if the graphs do not contain a cycle of length four and three as an induced subgraph, respectively. Phylogeny graphs are variant of competition graphs. The phylogeny graph $P(D)$ of a digraph $D$ is the (simple undirected) graph defined by $V(P(D)):=V(D)$ and $E(P(D)):=\{xy \mid N^+_D(x) \cap N^+_D(y) \neq \emptyset \}
The competition graph of a digraph D is a graph which has the same vertex set as D and has an edge between x and y if and only if there exists a vertex v in D such that (x, v) and (y, v) are arcs of D. For any graph G, G together with sufficiently many isolated vertices is the competition graph of some acyclic digraph. The competition number k(G) of a graph G is defined to be the smallest number of such isolated vertices. In general, it is hard to compute the competition number k(G) for a graph
Abstract Let k and ℓ be positive integers. A cycle with two blocks is a digraph obtained by an orientation of an undirected cycle, which consists of two internally (vertex) disjoint paths of lengths at least k and ℓ, respectively, from a vertex to another one. A problem of Addario‐Berry, Havet and Thomassé [ J. Combin. Theory Ser. B 97 (2007), 620–626] asked if, given positive integers k and ℓ such that , any strongly connected digraph D containing no has chromatic number at most . In this artic
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