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Since human papillomavirus (HPV) infection is strongly associated with cervical neoplasia and tumor hypoxia has prognostic significance in human cervical carcinomas, we examined the relationship between hypoxia and apoptosis in human cervical epithelial cells expressing high-risk HPV type 16 oncoproteins. In vitro, hypoxia stimulated both p53 induction and apoptosis in primary cervical epithelial cells infected with the HPV E6 and E7 genes but not in cervical fibroblasts infected with E6 and E7.

LEV may provide a survival benefit in patients with glioblastoma who receive temozolomide-based chemotherapy. A prospective randomized study may be indicated.

This technical note studies robustness of synchronization against heterogeneity of multi-agent systems. Here, heterogeneity also includes uncertainties and external disturbances in each agent. In order to effectively deal with the heterogeneous agents, we introduce the concept of the averaged dynamics which is the average of all agents' dynamics, and then claim that two sources enhance the robustness of synchronized behavior against heterogeneity of agents' dynamics. First, in spite of the heter

GK SRS may be useful as a primary or a secondary postoperative therapy for the treatment of CN. However, more attention should be paid to residual or recurrent CN during treatment, and regular long-term follow-up MRI should be mandatory to validate the procedure.

In this paper, we describe angular vertical-comb-drive torsional microactuators made in a new process that induces residual plastic deformation of single-crystal-silicon torsion bars. Critical dimensions of the vertically interdigitated moving-and fixed-comb actuators are self-aligned in the fabrication process and processed devices operate stably over a range of actuation voltages. We demonstrate MEMS scanning mirrors that resonate at 2.95kHz and achieve optical scan angles up to 19.2 degrees w

Broadband light absorbers are highly desirable in various applications including solar-energy harvesting, thermo-photovoltaics, and photon detection. The Fabry–Perot (F–P) cavity comprising metal–insulator–metal (MIM) layers has attracted enormous interest as a lithography-free structure for realizing planar super absorbers. However, typical F–P cavity exhibits a narrow absorption band, and efforts have thus been made to increase the absorption bandwidth. This study demonstrates that near-perfec

The prognosis of patients diagnosed with glioblastoma remains dismal in spite of the current concomitant chemoradiotherapy with temozolomide. In particular, the resistance to temozolomide appears to be the greatest obstacle to the treatment of glioblastoma. In the present study, we evaluated in vitro and in vivo the antitumor effects of combination therapy of cilengitide with belotecan, a camptothecin derivate, to treat experimental glioblastoma. The therapeutic effects of the drugs on the U87MG