신채원 교수

Plasma short-chain fatty acids were paradoxically increased in PD and were associated with disease severity and antiparkinsonian medications. Further studies are warranted to elucidate the relationships of gut dysbiosis and inflammation with plasma short-chain fatty acids. © 2020 International Parkinson and Movement Disorder Society.

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The study demonstrated that the NMS burdens are not associated with iron accumulation in the deep nuclei of patients with PD. These results suggest that future neuroimaging studies on the pathology of NMSs in PD should use more specific and detailed clinical tools and recruit PD patients with severe NMSs.

Hyposmia may be a predictive sign of cognitive decline in iRBD patients.

This study is the first demographic, clinical and genetic analyses in South Korea. These results will be helpful to stimulate more large-scale research in South Korea and other Asian nations.

The only characteristic of alpha-synuclein (AS) accumulation in the gastrointestinal (GI) tract of Parkinson's disease (PD) found in pathological studies is the "rostrocaudal gradient," which describes the more frequent presence of AS accumulation in the upper GI tract than in the lower GI tract. This study aimed to determine the diagnostic accuracy and identify predictors of AS accumulation in the GI tract of PD patients. The frequency of AS accumulation in the GI tract was compared between PD

Pathological studies on peripheral tissues have been conducted in patients with idiopathic rapid eye movement sleep behaviour disorder (iRBD) to investigate potential prodromal biomarkers before the development of overt synucleinopathies (online supplemental table 1). However, no studies have evaluated the in vivo tissues of the upper gastrointestinal (GI) tract in the iRBD population. Moreover, methodological heterogeneity makes it difficult to directly compare the results of each study on peri

Examining a large tissue volume increased the sensitivity of detecting AS accumulation in the GI tract.