东京大学、京都大学、大阪大学等日本QS前10名大学的研究室信息。
Professor Takuya Terahara's research lab specializes in advanced computational mechanics, focusing on space–time isogeometric analysis (ST-IGA) and T-splines-based methods for solving complex fluid–structure interaction (FSI) problems. The lab develops high-fidelity numerical methods to address challenges in hemodynamics—particularly in heart valve and ventricle-aorta flow simulations—by enabling accurate boundary layer resolution and contact modeling without mesh protection gaps. The lab also extends these methods to aerospace applications, such as parachute deployment and re-entry vehicle aerodynamics, using complex-geometry T-spline mesh generation for high-accuracy simulations. Their work emphasizes robust, high-order discretization techniques that maintain smoothness and continuity across multi-dimensional structural interfaces.
Professor Airo Hino's research lab specializes in comparative party system analysis, survey methodology, and digital data collection in political science. The lab investigates the emergence and success of new challenger parties in Western and East Asian democracies, with a focus on institutional and cultural factors shaping party system change. It also pioneers innovative methods for collecting and analyzing social media data and develops advanced statistical techniques to correct biases in survey responses, particularly in measuring value orientations like postmaterialism.
Professor Nobuaki Kono's research lab specializes in molecular biology and genomics, with a focus on understanding the genetic and molecular basis of biological materials—particularly spider silk—through integrative 'omics' approaches. The lab combines high-throughput sequencing, genome and transcriptome analysis, and proteomic characterization to decode the genotype-phenotype relationships in spider silk proteins, aiming to uncover the molecular mechanisms behind their exceptional mechanical properties. A key research direction involves the discovery and functional analysis of novel spidroin and non-spidroin proteins, especially in ecologically and industrially significant spider lineages such as Nephilinae and Araneus. The lab also develops bioinformatics tools, such as Pathway Projector, to visualize and integrate multi-omics data for systems biology applications.
Professor Ken J. Ishii's research lab focuses on innate immune sensing and dendritic cell biology, particularly how endogenous and exogenous DNA signals regulate antigen-presenting cell maturation and adaptive immunity. The lab investigates the role of genomic DNA released from dying cells as a damage-associated molecular pattern (DAMP) that activates dendritic cells through Toll-like receptor 9 (TLR9) and other cytosolic sensors. A central theme is understanding how the physical properties of DNA—such as length, structure, and concentration—influence immune responses, with implications for vaccine development and autoimmunity. The lab also explores how these mechanisms contribute to immune surveillance during infection and tissue injury.
Professor Jun Kunisawa's research lab focuses on the intricate interplay between diet, gut microbiota, and host immunity, with a particular emphasis on how microbial and dietary metabolites regulate immune homeostasis and function. The lab investigates the roles of specific micronutrients—such as B vitamins and ω3 polyunsaturated fatty acids—in shaping immune cell development and function, especially regulatory T cells and IgA-producing plasma cells. Using integrative approaches combining immunology, metabolism, and metabolomics, the lab uncovers molecular mechanisms linking nutrition to immune regulation and inflammatory diseases. Their work highlights how gut microbial metabolites and host nutritional status jointly influence mucosal immunity and systemic health.
Professor Thomas Svensson's research lab focuses on the intersection of cardiovascular and mental health, with a strong emphasis on identifying modifiable risk factors for age-related cognitive decline, stroke, and atrial fibrillation. The lab investigates the role of physiological markers—such as HDL cholesterol and total cholesterol—alongside psychological stress and genetic susceptibility in predicting cardiovascular and neuropsychiatric outcomes. Utilizing large-scale population-based cohorts and advanced predictive modeling, including machine learning and wearable device validation, the lab aims to improve early detection and prevention strategies. Research also extends to physiological time series analysis, particularly heart rate dynamics, to support personalized risk assessment and disease monitoring.
Professor Tomoji Mashimo's research lab specializes in mammalian genome engineering and the development of genetically engineered animal models to study human diseases. The lab focuses on creating precise gene-targeted rat and mouse models using advanced technologies such as ZFNs, TALENs, and ENU mutagenesis to investigate genetic susceptibility to viral infections, immunodeficiencies, and neurological disorders. A central theme is the generation of immunodeficient rat models—such as SCID and FSG rats—that serve as powerful tools for xenotransplantation, drug testing, and gene therapy evaluation. The lab also explores the functional roles of genes involved in neurodevelopment and DNA repair, particularly in the context of epilepsy and neurodegenerative diseases.
Professor Hyung Do Kim's research lab specializes in perovskite solar cells, focusing on enhancing power conversion efficiency through advanced materials engineering and defect passivation. The lab explores fundamental mechanisms limiting device performance—such as open-circuit voltage loss, fill factor limitations, and non-radiative recombination—by employing innovative strategies like bio-inspired templates (e.g., M13 bacteriophage), polymeric additives for self-healing, and interface engineering. Their work emphasizes sustainable and eco-friendly approaches, including genetically engineered biomaterials and environmentally benign additives, to improve stability and efficiency. The lab also investigates the intrinsic loss mechanisms in optoelectronic devices using temperature-dependent measurements to guide next-generation photovoltaic design.
Professor Hajime Yamazaki's research lab focuses on the metabolic and imaging aspects of insulin resistance and type 2 diabetes mellitus (T2DM), with a particular emphasis on ectopic fat accumulation in organs such as the liver, pancreas, and skeletal muscle. The lab employs advanced imaging techniques like unenhanced CT and peripheral perfusion imaging to investigate the pathophysiological links between fat distribution, microcirculation, and diabetes onset. They also explore cutaneous markers of insulin resistance and the role of molecular targets like megalin in autoimmune kidney diseases. Their work bridges clinical imaging, metabolic disease mechanisms, and translational biomarker discovery.
Professor Yoshiyuki Manabe's research lab specializes in synthetic organic chemistry and chemical biology, with a focus on the development of innovative methodologies for the selective functionalization of complex molecules, particularly C–H bonds and glycans. The lab pioneers microfluidic techniques for selective bromination and applies advanced strategies such as the diacetyl protection method to streamline the synthesis of biologically relevant oligosaccharides. Additionally, the lab is actively engaged in vaccine design through co-assembly of lipidated antigens and adjuvants, and in target protein identification using affinity-based tagging techniques for bioactive metabolites.
Professor Makoto Nakajima's research lab specializes in terahertz science and technology, focusing on the generation, manipulation, and application of terahertz radiation using advanced materials and nanostructures. Key research directions include ultrafast dynamics in correlated oxides (e.g., VO₂), magnetically and electrically tunable terahertz emitters, and metamaterial-based perfect absorbers for broadband and polarization-sensitive terahertz applications. The lab also explores novel materials such as metal nanoparticle inks and dielectric microspheres for scalable, low-cost terahertz devices.
Professor Atsushi Maruyama's research lab specializes in the development of advanced biomaterials and molecular tools for gene delivery and regulation. The lab focuses on designing functional nanomaterials—particularly polymeric nanoparticles and comb-type polycations—engineered for efficient polynucleotide delivery and stabilization of nucleic acid structures such as DNA triplexes and Z-DNA. Their work bridges polymer chemistry, molecular biology, and biotechnology, with applications in gene therapy and synthetic biology. The lab also investigates the molecular interactions between polycations and DNA to overcome challenges in solubility, stability, and targeted delivery.
Professor Hiroshi Kimurâ's research lab specializes in chromatin dynamics and transcription regulation in eukaryotic cells, focusing on the epigenetic mechanisms governing gene expression and genome stability. The lab employs advanced live-cell imaging techniques, such as photobleaching and fluorescent protein tagging, to study the dynamics of histones, RNA polymerase II, and their associated complexes in real time. Key research directions include histone modifications (e.g., acetylation and methylation of H3), nucleosome assembly, and the functional organization of transcription machinery in interphase and mitosis. The lab also investigates the kinetic behavior and assembly states of RNA polymerase II holoenzymes, providing insights into transcriptional regulation and elongation.
Professor Alain Barrat's research lab specializes in the statistical physics and complex systems approach to understanding real-world networks, with a focus on weighted and time-varying networks. The lab investigates the structural and dynamical properties of networks in contexts such as social interactions, disease spreading, and infrastructure systems, using empirical data from wearable sensors and large-scale datasets. A central theme is the interplay between network topology, edge weights, and temporal dynamics, particularly in relation to epidemic spreading and public health interventions. The lab develops theoretical models and data-driven frameworks to capture the non-trivial evolution of network properties and their impact on collective phenomena.
Professor Takafumi Kubota's research lab specializes in neurological complications associated with infectious diseases and vaccinations, with a particular focus on post-infectious and post-vaccinal autoimmune and inflammatory disorders of the nervous system. The lab investigates rare neurological manifestations such as cranial nerve palsies, demyelinating neuropathies, and autoimmune encephalopathies linked to SARS-CoV-2 infection and mRNA vaccines. Key research directions include the immunological and neurophysiological mechanisms underlying conditions like anti-GQ1b antibody-associated oculomotor palsy, chronic inflammatory demyelinating polyneuropathy (CIDP), and long COVID-related neuropsychiatric symptoms. The lab integrates clinical neurology, immunology, and neuroimaging to improve diagnosis and treatment of these rare but significant neurological sequelae.
Professor Masayoshi Nakamura's research lab focuses on the molecular mechanisms underlying cortical microtubule dynamics and organization in higher plants, with a particular emphasis on microtubule nucleation, minus-end protection, and reorientation in response to environmental cues. The lab investigates key regulatory proteins such as γ-tubulin complex components, SPIRAL2, and GIP1, which control microtubule stability, turnover, and array reorganization. Using live-cell imaging, genetic approaches, and hormone signaling analysis, the lab explores how cytoskeletal reorganization contributes to cell growth, development, and environmental adaptation. Their work provides fundamental insights into plant cell polarity and morphogenesis without centrosomes.
Professor Zhongyue Zhang's research lab specializes in the design, synthesis, and application of metal-organic frameworks (MOFs) with tailored electronic and redox properties for advanced energy storage and conversion technologies. The lab focuses on developing porous, conductive, and redox-active MOFs—particularly 2D and quasi-2D frameworks—enabling novel electrochemical mechanisms such as bipolar charging and guest-induced charge transfer. Their work bridges materials chemistry, solid-state electrochemistry, and magnetic characterization to explore fundamental charge storage processes and emergent electronic phenomena in MOFs.
Professor Hiroyuki Morimoto's research lab specializes in the development of novel catalytic systems for selective C–C and C–heteroatom bond formation, with a strong focus on transition-metal-catalyzed fluorination and functionalization reactions. Key research directions include the design of copper(I)-phenanthroline complexes for mild trifluoromethylation and perfluoroalkylation of aryl halides, lanthanum-based catalysts for direct amidation and asymmetric Mannich-type reactions, and innovative activation strategies for trichloromethyl ketones as propionate equivalents. The lab emphasizes atom-economical, selective transformations under mild conditions, enabling the synthesis of complex building blocks for pharmaceuticals and natural products. These efforts are underpinned by mechanistic studies and the strategic use of ligand control to achieve high enantioselectivity and diastereoselectivity.
Professor Naoya Shindo's research lab specializes in the development of innovative catalytic methodologies and covalent inhibition strategies for complex molecule synthesis and therapeutic target engagement. The lab focuses on tandem and domino catalysis, particularly auto-tandem and cascade reactions that enable efficient, stereoselective construction of nitrogen-containing heterocycles such as quinolines and axially chiral amidines. A key direction involves designing novel electrophilic warheads—like bicyclo[1.1.0]butane amides and chlorofluoroacetamides—for selective, irreversible inhibition of disease-relevant enzymes, including SARS-CoV-2 main protease. The lab integrates synthetic methodology, mechanistic DFT studies, and medicinal chemistry to advance both fundamental transformation science and drug discovery.
Professor Mikako Ogawa's research lab specializes in molecular imaging and targeted theranostics, focusing on the development of smart, activatable probes for precise detection and treatment of diseases such as cancer and atherosclerosis. Her team leverages near-infrared (NIR) fluorophores, antibody conjugates, and positron emission tomography (PET) tracers to enable real-time, high-contrast imaging of biological targets. Key research directions include the design of fluorescence-activatable probes that respond to cellular binding or enzymatic activity, and the application of photo-immunotherapy to induce immunogenic cell death in cancer cells. The lab also investigates the use of (18)F-FDG PET to monitor inflammation and therapeutic response in vulnerable atherosclerotic plaques.
