정대홍 교수

In this study, surface-enhanced Raman spectroscopy (SERS)-encoded magnetic nanoparticles (NPs) are prepared and utilized as a multifunctional tagging material for cancer-cell targeting and separation. First, silver-embedded magnetic NPs are prepared, composed of an 18-nm magnetic core and a 16-nm-thick silica shell with silver NPs formed on the surface. After simple aromatic compounds are adsorbed on the silver-embedded magnetic NPs, they are coated with silica to provide them with chemical and

Flat arrays (rafts) of aligned silver nanowires were fabricated by electrodepositing silver in the nanopores of highly ordered anodic alumina templates and then releasing the silver nanowires and depositing them on an oxidized, single-crystal silicon surface. SERS spectra were recorded from Rhodamine 6G molecules adsorbed onto the rafts. The SERS spectra showed striking polarization dependence according to the relative disposition of the E-vector with respect to the nanowires' axes. The observat

Abstract For the effective application of surface‐enhanced Raman scattering (SERS) nanoprobes for in vivo targeting, the tissue transparency of the probe signals should be as high as it can be in order to increase detection sensitivity and signal reproducibility. Here, near‐infrared (NIR)‐sensitive SERS nanoprobes (NIR SERS dots) are demonstrated for in vivo multiplex detection. The NIR SERS dots consist of plasmonic Au/Ag hollow‐shell (HS) assemblies on the surface of silica nanospheres and sim

Potential utilization of proteins for early detection and diagnosis of various diseases has drawn considerable interest in the development of protein-based multiplex detection techniques. Among the various techniques for high-throughput protein screening, optically-encoded beads combined with fluorescence-based target monitoring have great advantages over the planar array-based multiplexing assays. This review discusses recent developments of analytical methods of screening protein molecules on

A seedless, one-step synthetic route to uniform bumpy silver nanoshells (AgNSs) as highly NIR sensitive SERS substrates is reported. These substrates can incorporate Raman label compounds and biocompatible polymers on their surface. AgNS based NIR-SERS probes are successfully applied to cell tracking in a live animal using a portable Raman system.

Antibody-conjugated nanoparticles (NPs) have attracted great attention in diagnostic and therapeutic applications due to their high sensitivity and specificity for biotargets, as well as their wide applicability. Unfortunately, these features are significantly affected by antibody conjugation methods in terms of conjugation efficiency, orientation of the target binding site in the antibody, and denaturation during chemical conjugation reactions. Furthermore, the number of conjugated antibodies o

Peptides synthesized on microbeads were encoded by chemically and physically adsorbing surface-enhanced Raman spectroscopic nanoparticles (SERS dots) on the microbead surface during the synthesis, which could be easily and rapidly decoded by Raman spectroscopy.

A molecular detection method utilizing the magnetically induced aggregation of silver nanoparticle (NP)-embedded silica NPs for SERS activation is described. Here, silver embedded magnetic NPs (Ag-M-dots) composed of a magnetic core and silica shells, on whose surface silver NPs were formed, were used. Because the magnetic field induced aggregated Ag-M-dots exhibit a strong SERS signal compared to the dispersed Ag-M-dots, the system allows for the detection of adsorbed Raman label compound even

Multimodal imaging can provide complementary biomedical information which has huge potential in pre-clinical and clinical imaging and sensing. In this study, we introduce dual modal NIR silver bumpy nanoprobes for in vivo imaging and multiplexed detection of biomolecules by both photoacoustic imaging (PAI) and surface-enhanced Raman scattering (SERS) techniques. For this study, we used silica-coated silver bumpy nanoshell probes (AgNS@SiO₂). AgNS@SiO₂ have strong NIR-absorp

Surface‐enhanced Raman scattering ( SERS ) has attracted considerable interest as a sensitive vibration‐specific probe for bioanalytical and imaging applications. Among the various bioprobes available, Ag‐embedded SERS tags have been rigorously developed for an extensive range of biodetection applications. In this review, we look at the additional functionality that SERS tags can offer via its magnetic properties, fluorescence, and an extension of the optical region into the near‐infrared ( NIR

Morphology control of the surface of a nanostructure is a key issue in modulating its surface plasmon resonance and scattering properties. Here, we studied the effect of alkylamines on morphology control during the one-step fabrication of silver nanoshells (NSs) for highly enhanced Raman scattering. Various types of alkylamines were used to study the effects of chain length, existence of hydroxyl groups, and degree of alkyl chains on the surface morphology of silver NSs. The alkylamines influenc