김동영 교수
Dong-Young Kim
서울대학교 · 의학
연구실 소개
김동영 교수의 연구실은 생물학적 단백질 품질 제어 메커니즘과 신경망 하드웨어 최적화를 두 축으로 연구를 전개하고 있습니다. 특히 세균의 페리플라즘에서 단백질 분해와 리모델링을 담당하는 HtrA 단백질의 기능적 전환 메커니즘을 구조생물학적 접근으로 규명하고 있으며, 동시에 딥러닝 기반의 초고성능·저에너지 소비 신경망 하드웨어 아키텍처 설계 기술을 개발하고 있습니다. 이는 의료·반도체·IoT 분야의 응용을 겨냥한 실용적 기술 혁신을 목표로 합니다.
연구 현황
연구 성과 추이
표시된 성과는 수집된 데이터 기준으로 산출되며, 일부 차이가 있을 수 있습니다.
주요 논문
15Generally, there were no significant differences in recurrence rates according to clinical stage or surgical approach. Given the rate of delayed recurrence, follow-up of >3 years is required. Moreover, surgeons should always consider combined approaches to reduce the chances of recurrence.
It has been observed that the majority of the kernel weights and input activations in the state-of-the-art convolution neural networks (CNNs) have zero values. This article proposes a CNN hardware accelerator that exploits this property to achieve significant performance and energy improvements.
It is imperative to accelerate convolutional neural networks (CNNs) due to their ever-widening application areas from server, mobile to IoT devices. Based on the fact that CNNs can be characterized by a significant amount of zero values in both kernel weights and activations, we propose a novel hardware accelerator for CNNs exploiting zero weights and activations. We also report a zero-induced load imbalance problem, which exists in zero-aware parallel CNN hardware architectures, and present a z
Although continuous positive airway pressure (CPAP) is the most effective treatment modality, poor adherence still remains a problem for obstructive sleep apnea (OSA) treatment and there is little evidence regarding how this might be improved. This study aims to analyze the anatomic and clinical factors of OSA subjects who failed to comply with CPAP therapy.The medical records of 47 OSA subjects who received CPAP therapy as a first-line treatment modality were retrospectively reviewed. The medic
Chronic rhinosinusitis (CRS) is one of the most common chronic diseases in adults and severely affects quality of life in patients. Although various etiologic and pathogenic mechanisms of CRS have been proposed, the causes of CRS remain uncertain. Abnormalities in the coagulation cascade may play an etiologic role in many diseases, such as asthma and other inflammatory conditions. While studies on the relationship between asthma and dysregulated coagulation have been reported, the role of the co
Recently, deep learning for automated sleep stage classification has been introduced with promising results. However, as many challenges impede their routine application, automatic sleep scoring algorithms are not widely used. Typically, polysomnography (PSG) uses multiple channels for higher accuracy; however, the disadvantages include a requirement for a patient to stay one or more nights in the lab wearing uncomfortable sensors and wires. To avoid the inconvenience caused by the multiple chan
Tumor-derived extracellular vesicles (EVs) have emerged as a promising source of circulating biomarkers for liquid biopsies. However, understanding the heterogeneous physical and biochemical properties of EVs originating from multiple complex biogenesis pathways remains a major challenge. Here, we introduce EV-Ident for preparation of subpopulations of EVs in three different size fractions: large EVs (EV<sub>200 nm</sub>; 200-1 000 nm), medium EVs (EV<sub>100 nm</sub>; 100-200 nm), and small EVs
This study demonstrated that ED in OSAS may improve following UPPP. Better disease-specific QOL was observed after both surgical and nonsurgical therapies in OSAS. These findings suggest that interventions for OSAS can provide the alleviation of ED and increase QOL in OSAS patients with ED, especially if they had pronounced complaints of ED and wide neck circumferences.
Transmitted light microscopy can readily visualize the morphology of living cells. Here, we introduce artificial-intelligence-powered transmitted light microscopy (AIM) for subcellular structure identification and labeling-free functional analysis of live cells. AIM provides accurate images of subcellular organelles; allows identification of cellular and functional characteristics (cell type, viability, and maturation stage); and facilitates live cell tracking and multimodality analysis of immun
Uncontrolled activation of transforming growth factor (TGF)-β results in a wide range of pathologic conditions. Therapeutic interventions to regulate TGF-β signaling during fibrosis have been developed but the effectiveness is still limited. Here, we show that developmental endothelial locus-1 (Del-1) ameliorates fibrosis in mice by inhibiting α<sub>v</sub> integrin-mediated activation of TGF-β. Del-1 bound to α<sub>v</sub>β<sub>6</sub> integrin, an important activator of TGF-β, and inhibited th
Our study showed that management of allergic rhinitis might be associated with improvement of attention.
This study demonstrated that VSK could generate clear quantitative documentation of fine vibrations of vocal folds in many different types of benign lesion. VSK has the potential to be an effective tool for the quantitative analysis of vibratory patterns of vocal folds in clinical settings.
The symptoms of chronic rhinosinusitis such as nasal obstruction, purulent rhinorrhea, and postnasal drip were commonly present in both primary and secondary infections, and the sphenoid sinus was commonly involved in secondary infection. The radiological findings in fungal sinusitis included haziness, calcification, and bone destruction of the involved sinuses. CT scans in 80% of the primary and 69% of the secondary cases revealed calcific densities in a paranasal soft tissue mass. Twenty-eight
Although continuous positive airway pressure (CPAP) is a highly efficacious treatment for obstructive sleep apnea (OSA), there is a need for alternative treatment options, such as sleep surgeries and mandibular advancement devices (MADs), to overcome the limitations of CPAP.This study aimed to analyze the therapeutic outcomes of OSA subjects who were treated with a MAD, and to estimate the clinical impact of MAD as a first-line treatment for OSA.Forty-seven patients diagnosed with OSA received a
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