Seoul National University · 医学
Professor Donghyun Kang's research lab focuses on the molecular mechanisms underlying osteoarthritis (OA) and age-related joint diseases, with a particular emphasis on redox homeostasis, chondrocyte senescence, and extracellular matrix metabolism. The lab investigates the roles of key regulators such as selenoproteins, microRNAs (e.g., miR-204), and post-translational modifications (e.g., O-GlcNAcylation) in driving OA pathology. Using integrative approaches combining molecular biology, animal models, and translational studies, the lab aims to identify novel therapeutic targets for degenerative joint diseases.
Figures are computed from collected data and may differ slightly.
As an essential nutrient and trace element, selenium is required for living organisms and its beneficial roles in human health have been well recognized. The role of selenium is mainly played through selenoproteins synthesized by the selenium metabolic system. Selenoproteins have a wide range of cellular functions including regulation of selenium transport, thyroid hormones, immunity, and redox homeostasis. Selenium deficiency contributes to various diseases, such as cardiovascular disease, canc
A progressive loss of cartilage matrix leads to the development of osteoarthritis (OA). Matrix homeostasis is disturbed in OA cartilage as the result of reduced production of cartilage-specific matrix and increased secretion of catabolic mediators by chondrocytes. Chondrocyte senescence is a crucial cellular event contributing to such imbalance in matrix metabolism during OA development. Here, we identify miR-204 as a markedly up-regulated microRNA in OA cartilage. miR-204 is induced by transcri
Abstract Aging and mechanical overload are prominent risk factors for osteoarthritis (OA), which lead to an imbalance in redox homeostasis. The resulting state of oxidative stress drives the pathological transition of chondrocytes during OA development. However, the specific molecular pathways involved in disrupting chondrocyte redox homeostasis remain unclear. Here, we show that selenophosphate synthetase 1 (SEPHS1) expression is downregulated in human and mouse OA cartilage. SEPHS1 downregulat
UDP-GlcNAc serves as a building block for glycosaminoglycan (GAG) chains in cartilage proteoglycans and simultaneously acts as a substrate for O-GlcNAcylation. Here, we show that transporters for UDP-GlcNAc to the endoplasmic reticulum (ER) and Golgi are significantly downregulated in osteoarthritic cartilage, leading to increased cytosolic UDP-GlcNAc and O-GlcNAcylation in chondrocytes. Mechanistically, upregulated O-GlcNAcylation governs the senescence-associated secretory phenotype (SASP) by
Topical instillation of diquafosol increases tear film LLT in DED patients. Diquafosol 3% eye drop might be effective treatment option of evaporative DED with meibomian gland dysfunction.
The shear connector of a steel composite bridge is designed by predicting fatigue life using the fatigue strength curves (S-N curve) based on push-out test results. The fatigue strength curves of the current design codes present only a linear relationship between the stress range and fatigue life on a log scale based on push-out experiment results. However, an alternative to the current empirical formula is necessary for the fatigue design of shear connections involving many detailed variations
Abstract A rapid and simple method using two pipettes was developed to determine the presence of Listeria monocytogenes/Listeria spp. or Salmonella typhimurium/Salmonella spp. in mixed cultures. This method involved the following steps. A 10 mL pipette with a sealed tip was used for the enrichment phase. Lactose broth for Salmonella spp., and Universal preenrichment broth for Listeria spp. were used as enrichment broth. The broth was inoculated with a mixture of target organisms with Escherichia
Periprosthetic tissue inflammation is a challenging complication arising in joint replacement surgeries, which is often caused by wear debris from polyethylene (PE) components. In this study, we examined the potential biological effects of grafting a [2-(methacryloyloxy)ethyl]dimethyl-(3-sulfopropyl)ammonium hydroxide (MEDSAH) polymer onto the surface of PE through a solvent-evaporation technique. J774A.1 macrophage-like cells and primary cultured mouse osteoblasts were treated with PE powder wi
The findings indicate that 915 MHz microwave processing could be an effective method for the food industry to use in peanut butter pasteurization as it achieves pathogen reduction without compromising product quality. © 2025 Society of Chemical Industry.
Market bubbles emerge when asset prices are driven unsustainably higher than asset values and shifts in belief burst them. We demonstrate the same phenomenon for biomedical knowledge when promising research receives inflated attention. We predict deflationary events by developing a diffusion index that captures whether research areas have been amplified within social and scientific bubbles or have diffused and become evaluated more broadly. We illustrate our diffusion approach contrasting the tr
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