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장은화 교수

Eun-Hwa Jang

서울대학교 · 컴퓨터과학

연구실 소개

장은화 교수 연구실은 TCTP(역전사 조절 종양 단백질)의 다기능적 기능에 초점을 맞춰, 암 치료 타겟으로서의 잠재성과 대사 질환 조절 메커니즘을 연구하고 있습니다. 특히 TCTP가 세포 성장과 생존 조절뿐 아니라, 자가분해 작용인 아폽토시스와 자가포식을 조절하는 신호전달 경로에서 핵심 역할을 한다는 점을 규명하고 있습니다. 또한 난세포 활성화를 통해 체내 에너지 소비를 증가시키는 기전을 통해 비만 및 인슐린 저항성 등 대사질환의 치료적 접근법을 모색하고 있습니다.

TCTP암 치료대사 질환자가포식에너지 대사

연구 현황

논문 수
382
총 인용 수
3,331
최근 5년 논문
143
주요 분야
컴퓨터과학

연구 성과 추이

표시된 성과는 수집된 데이터 기준으로 산출되며, 일부 차이가 있을 수 있습니다.

5개년 연도별 논문 게재 수
143총합
2022
2023
2024
2025
2026
5개년 연도별 피인용 수
718총합
20222023202420252026

주요 논문

15
1
논문|인용수 144·2004
An Accurate Approach of Nonlinearity Compensation for VSI Inverter Output Voltage
Hai Zhao, Qiong Wu, Atsuo Kawamura
SJR Q1FWCI 3.7IEEE Transactions on Power Electronics

An accurate nonlinearity compensation technique for voltage source inverter (VSI) inverters is presented in this paper. Because of the nonlinearity introduced by the dead time, turn-on/off delay, snubber circuit and voltage drop across power devices, the output voltage of VSI inverters is distorted seriously in the low output voltage region. This distortion influences the output torque of IM motors for constant V/f drives. The nonlinearity of the inverter also causes 5th and 7th harmonic distort

Electrical and Electronic EngineeringEngineering
2
리뷰|인용수 141·2007
Chinese Word Segmentation: A Decade Review
Hai Zhao
FWCI 9.9Zhongwen xinxi xuebao

During the last decade,especially since the First International Chinese Word Segmentation Bakeoff was held in July 2003,the study in automatic Chinese word has been greatly improved.Those improvements could be summarized as following:(1) on the computation sense Chinese words in real text have been well-defined by segmentation guidelines + lexicon + segmented corpus;(2) practical results show that performance of statistic systems outperforms that of handcrafted rule-based systems;(3) the evaluat

Artificial IntelligenceComputer Science
3
논문|인용수 108·2008
Unsupervised Segmentation Helps Supervised Learning of Character Tagging for Word Segmentation and Named Entity Recognition
Hai Zhao, Chunyu Kit
FWCI 17.1

This paper describes a novel character tag-ging approach to Chinese word segmenta-tion and named entity recognition (NER) for our participation in Bakeoff-4.1 It integrates unsupervised segmentation and conditional random fields (CRFs) learning successfully, using similar character tags and feature tem-plates for both word segmentation and NER. It ranks at the top in all closed tests of word segmentation and gives promising results for all closed and open NER tasks in the Bake-off. Tag set selec

Artificial IntelligenceComputer Science
4
논문|인용수 80·2010
A Unified Character-Based Tagging Framework for Chinese Word Segmentation
Hai Zhao, Changning Huang, Mu Li, Bao‐Liang Lu
FWCI 8.5ACM Transactions on Asian Language Information Processing

Chinese word segmentation is an active area in Chinese language processing though it is suffering from the argument about what precisely is a word in Chinese. Based on corpus-based segmentation standard, we launched this study. In detail, we regard Chinese word segmentation as a character-based tagging problem. We show that there has been a potent trend of using a character-based tagging approach in this field. In particular, learning from segmented corpus with or without additional linguistic r

Artificial IntelligenceComputer Science
5
논문|인용수 59·2010
Integrating unsupervised and supervised word segmentation: The role of goodness measures
Hai Zhao, Chunyu Kit
SJR Q1FWCI 6.6Information Sciences
Artificial IntelligenceComputer Science
6
논문|인용수 32·2020
L-carnitine treatment attenuates renal tubulointerstitial fibrosis induced by unilateral ureteral obstruction
Hai Zhao, Hui Ying Li, Jian Jin, Ji Zhe Jin, Long Ye Zhang, Mei Ying Xuan, Xue Mei Jin, Yu Jiang, Hai Zheng, Ying Jin, Yong Jin, Bum Soon Choi
SJR Q2FWCI 2.9The Korean Journal of Internal MedicineOA

LC protects against the progression of tubulointerstitial fibrosis in an obstructed kidney.

Nutrition and DieteticsNursing
7
논문|인용수 15·2016
Ideal cardiovascular health and incident hypertension
Hai Zhao, Xiao Xue Liu, An Xin Wang, Yun Wu, Xiaoming Zheng, Xiao Hong Zhao, Kai Cui, Chun Yu Ruan, Cheng Zhi Lu, Jost B. Jonas, Shou Ling Wu
SJR Q3FWCI 1.1MedicineOA

Ideal cardiovascular health (CVH) has been defined by the American Heart Association as the absence of disease and presence of 7 key health factors. Since it is unknown whether cumulative exposure to CVH reduces the risk of developing arterial hypertension, we prospectively examined the potential association between cumulative CVH (cumCVH) score (except for blood pressure metrics) and incident hypertension.Of the 101,510 participants with an age range of 18 to 98 years in this longitudinal commu

Cardiology and Cardiovascular MedicineMedicine
8
논문|인용수 9·2023
EM Pre-training for Multi-party Dialogue Response Generation
Yiyang Li, Hai Zhao
FWCI 1.6OA

Dialogue response generation requires an agent to generate a response according to the current dialogue history, in terms of which two-party dialogues have been well studied, but leaving a great gap for multi-party dialogues at the same time. Different from two-party dialogues where each response is a direct reply to its previous utterance, the addressee of a response utterance should be specified before it is generated in the multi-party scenario. Thanks to the huge amount of two-party conversa

Artificial IntelligenceComputer Science
9
book chapter|인용수 9·2004
A Modular k-Nearest Neighbor Classification Method for Massively Parallel Text Categorization
Hai Zhao, Bao‐Liang Lu
SJR Q2FWCI 0.9Lecture notes in computer science
Artificial IntelligenceComputer Science
10
book chapter|인용수 7·2005
Improvement on Response Performance of Min-Max Modular Classifier by Symmetric Module Selection
Hai Zhao, Bao‐Liang Lu
SJR Q2FWCI 0.5Lecture notes in computer science
Artificial IntelligenceComputer Science
11
논문|인용수 7·2023
Reading bots: The implication of deep learning on guided reading
Baorong Huang, Juhua Dou, Hai Zhao
SJR Q2FWCI 1.2Frontiers in PsychologyOA

This study introduces the application of deep-learning technologies in automatically generating guidance for independent reading. The study explores and demonstrates how to incorporate the latest advances in deep-learning-based natural language processing technologies in the three reading stages, namely, the pre-reading stage, the while-reading stage, and the post-reading stage. As a result, the novel design and implementation of a prototype system based on deep learning technologies are present

Artificial IntelligenceComputer Science
12
논문|인용수 7·2007
Effective Subsequence-Based Tagging for Chinese Word Segmentation
Hai Zhao, Chunyu Kit
FWCI 1.5Zhongwen xinxi xuebao

The research of automatic Chinese word segmentation has been advancing rapidly in recent years, espe- cially since the First International Chinese Word Segmentation Bakeoff held in 2003. In particular, character-based tagging has claimed a great success in this field. In this paper, we attempt to generalize this method to subse- quence-based tagging. Our goal is to find longer tagging units through a reliable algorithm. We propose a two-step framework to serve this purpose. In the first step, an

Artificial IntelligenceComputer Science
13
논문|인용수 7·2010
A Web-Based Workflow System Design and Implementation
Hai Zhao, Dianfu Ma, Jinpeng Huai, Wei Li, Zhang Han-li
SJR Q4FWCI 0.5Beijing Hangkong Hangtian Daxue xuebao

The combination of workflow technologies and software application systems is one of the research directions in computer application area. On the basis of researches of workflow technology, a Web based Workflow System (WebWFS), which is based on script interpreter and is independent of application data, is presented. OOD method is used in workflow engine and a description language based on the script and a IIS Filter are discussed. In order to verify the adaptability of WebWFS, a example which is

Artificial IntelligenceComputer Science
14
논문|인용수 5·2023
Logistics Distribution Route Optimization Based on Improved Particle Swarm Optimization
Hai Zhao, Ashutosh Sharma
SJR Q3FWCI 1.0InformaticaOA

This article improves the logistics distribution route and improves the distribution as well as transportation efficiency. The article combines the features of logistics dissemination along with mathematical designing of dissemination automobile routing issue. The mountain climbing procedure with strong local search ability is introduced into the particle swarm optimization (PSO) procedure to improve the offered approach. Two mountain climbing schemes are offered in this article, and two differe

Industrial and Manufacturing EngineeringEngineering
15
논문|인용수 5·2001
Surface conditioning of NiTi and Ta stents
Hai Zhao, Jan Van Humbeeck, Ivan De Scheerder
FWCI 1.4Lirias (KU Leuven)

The present study explores the optimal methods for polishing NiTi and Ta stents. Electrochemical polishing was explored and several parameters were investigated including applied voltage, polishing time, and acid pickling prior to the polishing process. As a comparison, chemical polishing was also conducted. Both mechanical and electrochemical polishing of NiTi sheet materials were investigated to study the influence of electrochemical polishing on the surface composition of NiTi stents. Picklin

Mechanics of MaterialsEngineering

대표 연구 분야

Artificial IntelligenceControl and Systems EngineeringElectrical and Electronic EngineeringComputer Networks and CommunicationsCardiology and Cardiovascular MedicineInformation Systems

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