김학령 교수

Hypertension is the leading cause of death in human being, which shows high prevalence and associated complications that increase the mortality and morbidity. Controlling blood pressure (BP) is very important because it is well known that lowering high BP effectively improves patients’ prognosis. This review aims to provide a focused update of the 2018 Korean Hypertension Society Guidelines for the management of hypertension. The importance of ambulatory BP and home BP monitoring was further emp

This study was conducted to investigate the association between Helicobacter pylori (H. pylori) infection and the lipid profile among elderly Koreans. A total of 462 subjects (mean age 66.2 ± 7.6 yr, 84% males) who underwent health check-up were investigated. Each subject underwent gastroduodenoscopy with gastric mucosal biopsy, and H. pylori infection was determined by histopathological examination using the updated Sydney System score. The presence of H. pylori infection was significantly asso

This study was conducted to assess the relationship between estimated glomerular filtration rate (eGFR) and bone mineral density (BMD) in Korean postmenopausal women with mild renal dysfunction. A total of 328 postmenopausal women who underwent BMD measurement during health check-up was investigated. BMD was measured in lumbar spine (L1-L4), femoral neck, total proximal femur and femoral trochanteric areas by dual energy radiography absorptiometry and renal function was estimated by eGFR using C

This study was performed to evaluate the effects of diabetes on short- and mid-term clinical outcomes in patients with acute myocardial infarction (AMI). Between October 2005 and December 2009, a total of 22,347 patients with AMI from a nationwide registry was analyzed. At the time point of the day 30 after AMI onset, landmark analyses were performed for the development of major adverse cardiovascular events (MACEs), including death, re-infarction and revascularization. In this cohort, 6,131 pat

Background: Although some strategies are used for prophylaxis of contrast induced nephropathy, their efficacy is not fully established. Sarpogrelate can relieve vasospasm and have anti-inflammatory action. This study examined whether sarpogrelate reduces the incidence of contrast induced nephropathy (CIN) or subsequent renal impairment during four weeks after coronary angiography compared with a control group. Methods: Seventy-four participants with chronic renal failure were randomly assigned t

Background/Aims: Most current knowledge regarding amiodarone toxicity derivesfrom clinical trials. This study was performed to investigate the incidenceand risk factors of overall adverse effects of amiodarone in real-world practice usinga large sample size. Methods: Between January 1, 2000 and March 10, 2012, a total of 930 consecutivepatients who had been treated with amiodarone for arrhythmia were reviewedretrospectively. An amiodarone-associated adverse event was considered in casesof discon

Dyslipidemia in patients with diabetes is an important treatment target as a modifiable risk factor for cardiovascular disease (CVD). Although the primary treatment goal for dyslipidemia is to control low-density lipoprotein cholesterol (LDL-C), achieving this goal remains suboptimal according to recent studies. It is important to set the target goal for LDL-C control based on an accurate risk assessment for CVD. Here, we summarize the latest evidence on lipid management in patients with diabete

Background: Although coronary artery disease (CAD) is a major cause of out-of-hospital cardiac arrest (OHCA), there has been no convinced data on the necessity of routine invasive coronary angiography (ICA) in OHCA. We investigated clinical factors associated with obstructive CAD in OHCA. Methods: Data from 516 OHCA patients (mean age 58 years, 83% men) who underwent ICA after resuscitation was obtained from a nation-wide OHCA registry. Obstructive CAD was defined as the lesions with diameter st

Hepatitis A is one of the most common infectious diseases. It is a self-limiting disease affecting the liver. Although extrahepatic manifestations are not common, a few cases associated with renal diseases have been reported. In those cases, patients presented with acute tubular necrosis, acute interstitial nephritis, IgA nephropathy, mesangioproliferative glomerulonephritis, etc. We here report a case of interstitial nephritis and IgA nephropathy associated with acute hepatitis A. A previously

Although atrial fibrillation is the most frequent cause of embolic stroke, coronary embolism from atrial fibrillation is a very rare cause of acute myocardial infarction. Therefore, simultaneously presented acute ischemic stroke and acute myocardial infarction due to atrial fibrillation in the same patient has not been documented. The present report describes the case of a 58-year-old man with paroxysmal atrial fibrillation who initially presented with a large cerebral infarction due to embolic

Background Little is known about the characteristics of arterial stifness in heart failure (HF). This study was per‑ formed to compare the degree of arterial stifness and its association with left ventricular (LV) diastolic function among three groups: control subjects, patients with HF with reduced ejection fraction (HFrEF), and patients with HF with preserved ejection fraction (HFpEF). Methods A total of 83 patients with HFrEF, 68 patients with HFpEF, and 84 control subjects were analyzed. All

배경 및 목적스타틴은 심혈관계 질환의 일차적, 이차적 예방 효과가 증명된 약물이며, 고지혈증의 약물 치료로 많이 처방되고 있다. 본 연구에서는 치료 현실에서 여러 가지 이유로 스타틴 치료가 중단되었을 때 환자의 혈중 지질 수치가 시간이 지남에 따라 변화하는 양상에 대해 조사하였다.방 법서울시립 보라매병원 순환기내과에서 추적 관찰 중인 환자들 중에서 스타틴 처방이 중단되었던 총 69명 (남자 42%)의 환자들의 혈중 지질 수치를 분석하였다. 의무기록을 검토하여 환자의 당뇨병, 고혈압, 심혈관질환 여부 및 체질량 지수 등을 조사하였다. 결 과 환자들의 임상 병력을 보면, 28%에서 당뇨병을 동반하고 있었고, 72%가 고혈압을, 42%가 관상동맥질환을 동반하고 있었다. 스타틴 치료가 되고 있던 시점에서의 혈중 총 콜레스테롤 치는 163.8 mg/dL, LDL-C은 94.2±33.5 mg/dL 이었으며, 중성지방은 174.3 mg/dL, 고밀도지단백 콜레스테롤 치는 34.8 mg/dL였다.

LV systolic and diastolic functions may deteriorate, and proBNP levels could be elevated even by a single bout of treadmill exercise in untrained young subjects. Dynamic change in LV diastolic function is a major stimulus to NT-proBNP release following exercise in men but not in women.

Inclisiran and bempedoic acid (BA) are non-statin lipid-lowering agents that have been approved for use in the US and Europe. Inclisiran, a subcutaneously administered small interfering RNA targeting proprotein convertase subtilisin/kexin type 9 messenger RNA, is effectively delivered to the liver via lipid nanoparticles and conjugation. In several phase 3 trials, it has successfully reduced low-density lipoprotein cholesterol (LDL-C) by 50% and has an acceptable safety profile. Currently, the r

This study was conducted to determine clinical parameters predicting future major adverse cardiovascular events (MACEs) in patients without significant stenosis on coronary computed tomographic angiography (CCTA). A total of 625 patients with suspected coronary artery disease (CAD) who underwent CCTA that revealed insignificant (< 50%) CAD was reviewed in three cardiac centers. The MACEs including cardiac death, non-fatal myocardial infarction (MI), unstable angina and late (> 90 days after CCTA