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김희승 교수

Hee Seung Kim

서울대학교 · 의학

연구실 소개

김희승 교수의 연구실은 난소암 및 자궁경부암을 중심으로 한 소견암의 조기 진단, 치료 반응 예측 및 치료 부작용 완화를 위한 종합적 연구를 수행하고 있습니다. 특히 CA-125, PLR, NLR와 같은 생물학적 마커와 적응증 기반 치료 전략의 최적화에 초점을 맞추고 있으며, 전통 약재인 적삼초의 항암 효과 및 생존율 향상 가능성에 대해서도 실험적 접근을 통해 검증하고 있습니다. 또한, 약물-단백질 상호작용 분석 기술을 활용한 약물 설계 및 암 치료의 정밀화를 위한 기초 연구도 병행하고 있습니다.

난소암자궁경부암생물학적 마커적삼초약물-단백질 상호작용

연구 현황

논문 수
430
총 인용 수
6,269
최근 5년 논문
144
주요 분야
의학

연구 성과 추이

표시된 성과는 수집된 데이터 기준으로 산출되며, 일부 차이가 있을 수 있습니다.

5개년 연도별 논문 게재 수
144총합
2022
2023
2024
2025
2026
5개년 연도별 피인용 수
666총합
20222023202420252026

주요 논문

15
1
논문|인용수 98·2009
Genetic polymorphisms affecting clinical outcomes in epithelial ovarian cancer patients treated with taxanes and platinum compounds: A Korean population-based study
Hee Seung Kim, Mi‐Kyung Kim, Hyun Hoon Chung, Jae‐Weon Kim, Noh Hyun Park, Yong Sang Song, Soon Beom Kang
SJR Q1FWCI 9.7Gynecologic Oncology
Reproductive MedicineMedicine
2
논문|인용수 89·2008
Rapid analysis of the interactions between drugs and human serum albumin (HSA) using high-performance affinity chromatography (HPAC)
Hee Seung Kim, Irving W. Wainer
SJR Q2FWCI 3.2Journal of Chromatography B
Molecular BiologyBiochemistry, Genetics and Molecular Biology
3
논문|인용수 86·2004
Chromatographic analysis of carbamazepine binding to human serum albumin
Hee Seung Kim, David S. Hage
SJR Q2FWCI 1.8Journal of Chromatography B
Molecular BiologyBiochemistry, Genetics and Molecular Biology
4
논문|인용수 75·2015
Systemic Inflammatory Response Markers and CA-125 Levels in Ovarian Clear Cell Carcinoma: A Two Center Cohort Study
Hee Seung Kim, Hwa-Young Choi, Maria Lee, Dong Hoon Suh, Kidong Kim, Jae Hong No, Hyun Hoon Chung, Yong Beom Kim, Yong Sang Song
SJR Q1FWCI 4.3Cancer Research and TreatmentOA

CA-125 levels may be the most useful marker for predicting advanced-stage disease. Suboptimal debulking and platinum-resistance, and PLR and NLR may be most effective to predict non-CR and PFS in patients with OCCC.

OncologyMedicine
5
리뷰|인용수 60·2010
Systematic Lymphadenectomy for Survival in Epithelial Ovarian Cancer
Hee Seung Kim, Woong Ju, Byung Chul Jee, Yong Beom Kim, Noh Hyun Park, Yong Sang Song, Seung Cheol Kim, Soon‐Beom Kang, Jae‐Weon Kim
SJR Q1FWCI 5.5International Journal of Gynecological Cancer
Reproductive MedicineMedicine
6
논문|인용수 55·2009
International Federation of Gynecology and Obstetrics (FIGO) staging system revised: what should be considered critically for gynecologic cancer?
Hee Seung Kim, Yong Sang Song
SJR Q1FWCI 3.6Journal of Gynecologic OncologyOA

The International Federation of Gynecology and Obstetrics (FIGO), the first organization to develop a staging system of gynecologic cancer, became the official patron of the Annual Report for the development and changes of gynecologic cancer classification and staging since 1958.1 Thereafter, FIGO staging system has been structured to represent major prognostic factors in predicting patients' outcomes and lending order to the complex dynamic behavior of gynecologic cancers. The purpose of the FI

Obstetrics and GynecologyMedicine
7
논문|인용수 53·2017
Effect of Red Ginseng on Genotoxicity and Health-Related Quality of Life after Adjuvant Chemotherapy in Patients with Epithelial Ovarian Cancer: A Randomized, Double Blind, Placebo-Controlled Trial
Hee Seung Kim, Mi‐Kyung Kim, Maria Lee, Byung Su Kwon, Dong Jin Suh, Yong Sang Song
SJR Q1FWCI 2.5NutrientsOA

We evaluated the effect of red ginseng on toxicity, health-related quality of life (HRQL) and survival after adjuvant chemotherapy in patients with epithelial ovarian cancer (EOC). A total of 30 patients with EOC were randomly assigned to placebo (n = 15) and red ginseng groups (n = 15). All patients took placebo or red ginseng (3000 mg/day) for three months. Then, we compared changes of genotoxicity, HRQL and survival between the two groups. As a result, red ginseng reduced micronuclei yield in

Molecular BiologyBiochemistry, Genetics and Molecular Biology
8
논문|인용수 50·2010
Evaluation of serum CA-125 levels for preoperative counseling in endometrioid endometrial cancer: A multi-center study
Hee Seung Kim, Chan-Yong Park, Jong‐Min Lee, Jae Kwan Lee, Chi‐Heum Cho, Seok‐Mo Kim, Jae‐Weon Kim
SJR Q1FWCI 3.6Gynecologic OncologyOA
Reproductive MedicineMedicine
9
리뷰|인용수 45·2015
Conventional versus nerve-sparing radical surgery for cervical cancer: a meta-analysis
Hee Seung Kim, Keewon Kim, Seung-Bum Ryoo, Joung Hwa Seo, Sang Youn Kim, Ji Won Park, Sunghoon Kim, Kyoung Sup Hong, Chang Wook Jeong, Yong Sang Song, On behalf of FUSION Study Group
SJR Q1FWCI 5.7Journal of Gynecologic OncologyOA

NSRS may not affect prognosis and sexual dysfunctions in patients with cervical cancer, whereas it may decrease intraoperative complications, and urinary and anorectal dysfunctions despite long operative time and short length of the resected vagina when compared with CRS.

Obstetrics and GynecologyMedicine
10
논문|인용수 44·2009
Simultaneous analysis of liposomal doxorubicin and doxorubicin using capillary electrophoresis and laser induced fluorescence
Hee Seung Kim, Irving W. Wainer
SJR Q2FWCI 2.3Journal of Pharmaceutical and Biomedical AnalysisOA
Biomedical EngineeringEngineering
11
논문|인용수 41·2004
Development and evaluation of N-hydroxysuccinimide-activated silica for immobilizing human serum albumin in liquid chromatography columns
Hee Seung Kim, Young Sik Kye, David S. Hage
SJR Q1FWCI 1.6Journal of Chromatography A
SpectroscopyChemistry
12
논문|인용수 40·2002
Identification of drug-binding sites on human serum albumin using affinity capillary electrophoresis and chemically modified proteins as buffer additives
Hee Seung Kim, John S. Austin, David S. Hage
SJR Q2FWCI 1.8Electrophoresis

A technique based on affinity capillary electrophoresis (ACE) and chemically modified proteins was used to screen the binding sites of various drugs on human serum albumin (HSA). This involved using HSA as a buffer additive, following the site-selective modification of this protein at two residues (tryptophan 214 or tyrosine 411) located in its major binding regions. The migration times of four compounds (warfarin, ibuprofen, suprofen and flurbiprofen) were measured in the presence of normal or

Molecular BiologyBiochemistry, Genetics and Molecular Biology
13
논문|인용수 40·2013
Impact of Chemoradiation on Prognosis in Stage IVB Cervical Cancer with Distant Lymphatic Metastasis
Hee Seung Kim, Tae Hun Kim, Eung Seok Lee, Hak Jae Kim, Hyun Hoon Chung, Jae‐Weon Kim, Yong Sang Song, Noh Hyun Park
SJR Q1FWCI 2.1Cancer Research and TreatmentOA

CCR may be more effective than SC for improving survival, and can be regarded as a feasible method with some caution regarding late RT-related toxicity for treatment of stage IVB cervical cancer with distant lymphatic metastasis.

Obstetrics and GynecologyMedicine
14
논문|인용수 38·2010
Matched-case comparison for the efficacy of neoadjuvant chemotherapy before surgery in FIGO stage IB1-IIA cervical cancer
Hee Seung Kim, Ju-Yeong Kim, Noh Hyun Park, Kidong Kim, Hyun Hoon Chung, Yong Beom Kim, Jae‐Weon Kim, Hak Jae Kim, Yong Sang Song, Soon‐Beom Kang
SJR Q1FWCI 3.7Gynecologic Oncology
Obstetrics and GynecologyMedicine
15
book chapter|인용수 37·2005
Immobilization Methods for Affinity Chromatography
Hee Seung Kim, David S. Hage
Chromatographic science/Chromatographic science series
Molecular BiologyBiochemistry, Genetics and Molecular Biology

대표 연구 분야

Reproductive MedicineObstetrics and GynecologySurgeryOncologyMolecular BiologyEpidemiology

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