大阪大学 · 医学
Hideki Kanemoto教授の研究室は、神経変性疾患、特にレビー小体病(DLB)をはじめとする神経疾患の神経画像・行動症状・生活機能への影響を、臨床的・統計的・信号処理的手法を融合して解明しています。特に、視覚・聴覚幻覚や運動機能低下といった前駆症状の神経基盤や、認知機能低下に伴う家族介護者の負担要因の特定に注力しています。また、電波環境下における通信システムの誤り性能向上に関する信号モデルの構築も併行して行っています。
Figures are computed from collected data and may differ slightly.
Psychomotor slowing, visual hallucinations, and reduced perfusion in the occipital lobe may be suggestive of prodromal DLB in VLOSLP patients, even though the clinical manifestations were similar in many respects between VLOSLP+LB and VLOSLP-LB. Although auditory hallucinations were prevalent in both groups, most patients in VLOSLP+LB complained of auditory hallucinations along with visual hallucinations. Future studies with a larger number of patients without selection bias are desirable.
<b>Background/Objective:</b> Behavioral and psychological symptoms of dementia (BPSD) have been reported to affect caregiver burden in patients with dementia with Lewy bodies (DLB). However, the factor structure of BPSD and the factors that affect caregiver burden in DLB remain unknown. This study sought to classify BPSD and to reveal what type of BPSD affects caregiver burden in patients with DLB. <b>Methods:</b> We collected data on neuropsychiatric inventory-plus (NPI-plus), Zarit Burden Inte
Microwave oven interference seriously degrades the performance of digital radio communication systems, therefore, in order to obtain a good error performance under a microwave oven interference environment, the digital radio communication systems should be newly designed for this environment. In this paper, using the Middleton's (1977) canonical class-A impulsive noise model, we propose a statistical model of microwave oven interference and discuss the performance improvement achieved by optimum
The performance of digital radio communication systems is much degraded by the effect of microwave oven interference; therefore, in order to obtain a good error performance under microwave oven interference environment, digital radio communication systems should be designed for this environment. In this paper, using Middleton's canonical class-A impulsive noise model, the authors propose a statistical model of microwave oven interference and discuss the performance improvement achieved by an opt
Delusional infestation may be caused by DLB. Acetylcholinesterase inhibitors (AChEI) may be effective for delusional infestation in DLB, although antipsychotics may also be needed in severe cases.
TST and bodily activity during sleep are associated with dysfunction of the left pulvinar and the severity of hallucinations in patients with DLB.
Our findings suggest that right caudate dysfunction might cause apathy in iNPH patients.
A low CSF Aβ<sub>42/40</sub> ratio is associated with a poorer cognitive response, but not gait and urinary response, to a tap test in iNPH. Even if CSF biomarkers suggest AD comorbidity, treatment with iNPH may be effective for gait and urinary dysfunction.
Three neuropsychiatric syndromes - psychosis, agitation, and affective disturbance - may heterogeneously associate with AD, DLB, and MCI.
Abstract Since most of the noise generated by electronic equipment using high‐frequency devices has statistical properties that are quite different from Gaussian noise, the bit error rate of conventional receivers is greatly degraded in a man‐made noise environment, because they are designed with the presumption of Gaussian noise. One of the methods of providing a better bit error rate in such a noise environment is the use of an optimum receiver. This optimum receiver attains a high bit error r
Phenomenological assessments using photographs of the patient's home could identify the environmental triggers associated with VH in patients with DLB and assist in environmental adjustments.
The SF-DEM-J is acceptable as a measure of social function in MCI and mild dementia. Our results show that the social functioning of people with dementia, especially communicating with others, improved during the COVID-19 pandemic, probably as a result of adaptation to the restrictive life.
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