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김홍석 교수

Hong Seok Kim

서울대학교 · 의학

연구실 소개

김홍석 교수의 연구실은 세포 노화, 염증 반응 및 암 미세환경에서의 신호전달 경로의 조절 메커니즘을 중심으로 연구를 진행하고 있습니다. 특히 MAPK 경로와 관련된 단백질 인산화 효소(MKP)의 산화적 조절, 세포 노화와 관련된 신호 분해와 산화 스트레스의 상호작용을 규명하고 있으며, 이는 암 진행성 및 대사질환 관련 염증 반응의 분자 기전을 밝히는 데 기여하고 있습니다. 또한, 나노소재를 활용한 환경 정화 기술과 의료 기기의 임상적 응용 개발도 함께 진행하고 있습니다.

세포 노화MAPK 신호전달산화 스트레스나노소재암 미세환경

연구 현황

논문 수
116
총 인용 수
1,647
최근 5년 논문
51
주요 분야
의학

연구 성과 추이

표시된 성과는 수집된 데이터 기준으로 산출되며, 일부 차이가 있을 수 있습니다.

5개년 연도별 논문 게재 수
51총합
2021
2022
2023
2024
2025
5개년 연도별 피인용 수
533총합
20212022202320242025

주요 논문

15
1
논문|인용수 99·2010
Atmospherically Stable Nanoscale Zero-Valent Iron Particles Formed under Controlled Air Contact: Characteristics and Reactivity
Hong Seok Kim, Jun‐Young Ahn, Kyung‐Yup Hwang, Il-Kyu Kim, Inseong Hwang
SJR Q1FWCI 4.1Environmental Science & Technology

Atmospherically stable NZVI (nanoscale zero-valent iron) particles were produced by modifying shell layers of Fe(H2) NZVI particles (RNIP-10DS) by using a controlled air contact method. Shell-modified NZVI particles were resistant to rapid aerial oxidation and were shown to have TCE degradation rate constants that were equivalent to 78% of those of pristine NZVI particles. Fe(H2) NZVI particles that were vigorously contacted with air (rapidly oxidized) showed a substantially compromised reactivi

Biomedical EngineeringEngineering
2
논문|인용수 51·2020
Current and Future Burden of Periprosthetic Joint Infection from National Claim Database
Hong Seok Kim, Jung-Wee Park, Sun-Young Moon, Young‐Kyun Lee, Yong‐Chan Ha, Kyung‐Hoi Koo
SJR Q2FWCI 3.9Journal of Korean Medical ScienceOA

The incidence of PJI in Korea is comparable with reported PJI incidence of 2.0%-2.7% in the United States. Our findings would be used for worldwide comparison of PJI epidemiology and establishment of healthcare policies for PJI in East Asia.

SurgeryMedicine
3
논문|인용수 36·2021
Third-Generation Ceramic-on-Ceramic Total Hip Arthroplasty in Patients with Osteonecrosis of the Femoral Head
Hong Seok Kim, Jung-Wee Park, Joo Hyung Ha, Young‐Kyun Lee, Yong‐Chan Ha, Kyung‐Hoi Koo
SJR Q1FWCI 4.4Journal of Bone and Joint Surgery

III.

Orthopedics and Sports MedicineMedicine
4
논문|인용수 34·2009
Phosphorylated Extracellular Signal-regulated Protein Kinases 1 and 2 Phosphorylate Sp1 on Serine 59 and Regulate Cellular Senescence via Transcription of p21Sdi1/Cip1/Waf1
Hong Seok Kim, In Kyoung Lim
SJR Q1FWCI 2.0Journal of Biological ChemistryOA

Expression of p21(Sdi1) downstream of p53 is essential for induction of cellular senescence, although cancer cell senescence can also occur in the p53 null condition. We report herein that senescence-associated phosphorylated extracellular signal-regulated protein kinases 1 and 2 (SA-pErk1/2) enhanced p21(Sdi1) transcription by phosphorylating Sp1 on Ser(59) downstream of protein kinase C (PKC) alpha. Reactive oxygen species (ROS), which was increased in cellular senescence, significantly activa

PhysiologyMedicine
5
논문|인용수 33·2013
Regulation of Monocyte Adhesion and Migration by Nox4
Chi Fung Lee, Sarah L. Ullevig, Hong Seok Kim, Reto Asmis
SJR Q1FWCI 2.5PLoS ONEOA

We showed that metabolic disorders promote thiol oxidative stress in monocytes, priming monocytes for accelerated chemokine-induced recruitment, and accumulation at sites of vascular injury and the progression of atherosclerosis. The aim of this study was to identify both the source of reactive oxygen species (ROS) responsible for thiol oxidation in primed and dysfunctional monocytes and the molecular mechanisms through which ROS accelerate the migration and recruitment of monocyte-derived macro

ImmunologyImmunology and Microbiology
6
논문|인용수 30·2022
Prevalence of sarcopenia and mortality rate in older adults with hip fracture
Hong Seok Kim, Jung‐Wee Park, Young‐Kyun Lee, Jun‐Il Yoo, Yang‐Seon Choi, Byung‐Ho Yoon, Yong‐Chan Ha, Kyung‐Hoi Koo
SJR Q1FWCI 3.1Journal of the American Geriatrics Society

The prevalence of sarcopenia in hip fracture patients differed substantially according to ASM indices. Sarcopenic hip fracture patients had a higher mortality rate than those with normal musculature. The 1-year, 2-year, and 5-year mortality rates were discriminated by ASM/height<sup>2</sup> criteria in both men and women. Future prospective studies in a larger cohort are warranted.

PhysiologyMedicine
7
논문|인용수 21·2014
Significance of Serum Antibody Test for Toxocariasis in Healthy Healthcare Examinees with Eosinophilia in Seoul and Gyeongsangnam-do, Korea
Hong Seok Kim, Yan Jin, Min‐Ho Choi, Jae Hwan Kim, Young‐Ha Lee, Cheong Ha Yoon, Eui-Hyuk Hwang, Hun Kang, Sang-Yong Ahn, Gi Jin Kim, Sung‐Tae Hong
SJR Q2FWCI 5.2Journal of Korean Medical ScienceOA

There have been numerous reports on the relationship between eosinophilia and toxocariasis. The present study investigated seropositive rates of toxocariasis among healthy people with or without eosinophilia in urban and rural areas, and assessed risk factors for positive antibody test. A total of 610 healthy people, who visited health check-up (Medicheck®, Korea Association of Health Promotion), 310 from Seoul and 300 from Gyeongsangnam-do, were subjected for this study. Their serum samples wer

Emergency Medical ServicesHealth Professions
8
논문|인용수 18·2021
High Risk of Neck-liner Impingement and Notching Observed with Thick Femoral Neck Implants in Ceramic-on-ceramic THA
Hong Seok Kim, Jung-Wee Park, Soong Joon Lee, Young‐Kyun Lee, Yong‐Chan Ha, Kyung‐Hoi Koo
SJR Q1FWCI 2.3Clinical Orthopaedics and Related ResearchOA

Level III, therapeutic study.

SurgeryMedicine
9
논문|인용수 14·2011
A Domain in the Herpes Simplex Virus 1 Triplex Protein VP23 Is Essential for Closure of Capsid Shells into Icosahedral Structures
Hong Seok Kim, Eugene Huang, Jigisha Desai, Marieta Solé, Erin N. Pryce, Mercy E. Okoye, Stanley Person, Prashant Desai
SJR Q1FWCI 1.0Journal of Virology

VP23 is a key component of the triplex structure. The triplex, which is unique to herpesviruses, is a complex of three proteins, two molecules of VP23 which interact with a single molecule of VP19C. This structure is important for shell accretion and stability of the protein coat. Previous studies utilized a random transposition mutagenesis approach to identify functional domains of the triplex proteins. In this study, we expand on those findings to determine the key amino acids of VP23 that are

EpidemiologyMedicine
10
논문|인용수 14·2010
Detection Rates of Nonpalpable Prostate Cancer in Korean Men With Prostate-specific Antigen Levels Between 2.5 and 4.0 ng/mL
Hong Seok Kim, Seong Soo Jeon, Jae Duck Choi, Wansuk Kim, Deok Hyun Han, Byong Chang Jeong, Seong Il Seo, Kyu Sung Lee, Sung Won Lee, Hyun Moo Lee, Han Yong Choi
SJR Q2FWCI 0.7Urology
Pulmonary and Respiratory MedicineMedicine
11
논문|인용수 12·2021
Vitamin D Deficiency and Sarcopenia in Hip Fracture Patients
Hong Seok Kim, Geun Doo Jang, Jung-Wee Park, Young‐Kyun Lee, Kyung‐Hoi Koo
SJR Q2FWCI 1.0Journal of Bone MetabolismOA

Vitamin D deficiency was more prevalent in patients undergoing HFS than in patients undergoing elective THA. Among patients undergoing HFS, vitamin D deficiency was more prevalent in sarcopenic than in non-sarcopenic patients.

PhysiologyMedicine
12
논문|인용수 11·2008
Ocular Aberrations and Contrast Sensitivity in Eyes Implanted with Aspheric and Spherical Intraocular Lenses
Hong Seok Kim, Sang Woo Kim, Byung Jin Ha, Eung Kweon Kim, Tae‐im Kim
SJR Q4FWCI 1.0Journal of the Korean Ophthalmological SocietyOA

PURPOSE: To compare spherical aberration, higher-order aberration, and contrast sensitivity of eyes implanted with aspheric (AcrySof IQ) or spherical (AcrySof Natural) intraocular lenses. METHOD: Seventy-five eyes implanted with posterior chamber intraocular lenses were divided into two groups: AcrySof IQ (35 eyes) and AcrySof Natural (40 eyes). Wavefront analysis (spherical, higher-order and total aberration) using iTace, and contrast sensitivity (under photopic and mesopic condition) using Opt

EpidemiologyMedicine
13
논문|인용수 11·2014
Significance of Serum Antibody Test for Toxocariasis in Healthy Healthcare Examinees with Eosinophilia in Seoul and Gyeongsangnam-do, Korea
김홍석, JIN YAN, 최민호, 김재환, Young Ha Lee, Cheong Ha Yoon, Eui-Hyuk Hwang, Hun Kang, Sang-Yong Ahn, Gi Jin Kim, 홍성태
Journal of Korean Medical Science

There have been numerous reports on the relationship between eosinophilia andtoxocariasis. The present study investigated seropositive rates of toxocariasis amonghealthy people with or without eosinophilia in urban and rural areas, and assessed riskfactors for positive antibody test. A total of 610 healthy people, who visited health checkup(Medicheck®, Korea Association of Health Promotion), 310 from Seoul and 300 fromGyeongsangnam-do, were subjected for this study. Their serum samples were test

14
논문|인용수 8·2023
Ceramic‐on‐Ceramic or Metal‐on‐Polyethylene: The Bearing of Choice after Ceramic Component Fracture in Total Hip Arthroplasty along with Concise Follow‐Up of the Previous Cohort
Hong Seok Kim, Han Jin Lee, Soong Joon Lee, Jeong Joon Yoo
SJR Q1FWCI 2.5Orthopaedic SurgeryOA

We recommend the latest CoC as the bearing of choice in reoperation after the fracture of ceramic components. In the case of an MoP bearing after the ceramic component fracture, the risk of metallosis seemed high in the early postoperative period.

SurgeryMedicine
15
논문|인용수 4·2024
Quarter Century Outcomes of Alumina Ceramic-on-Ceramic Total Hip Arthroplasty
Hong Seok Kim, Jeong Joon Yoo
SJR Q1FWCI 2.3The Journal of Arthroplasty
SurgeryMedicine

대표 연구 분야

SurgeryPhysiologyOrthopedics and Sports MedicineImmunologyFood ScienceBiomedical Engineering

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