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Four aromatic alkaloids, ningalins A-D (1-4), three of which possess new carbon skeletons, were isolated from an undescribed ascidian of the genus Didemnumcollected in Western Australia near Ningaloo Reef. The structures of these new alkaloids were elucidated by interpretation of overall spectral data and by 2D NMR correlation methods. Ningalins A-D are composed of C(18), C(25), C(32), and C(40) condensed aromatic systems with the unifying theme that all appear derived via the condensation of th

ADVERTISEMENT RETURN TO ISSUEPREVNoteNEXTIsolation of Microbial Antibiotics from a Marine Ascidian of the Genus DidemnumHeonjoong Kang, Paul R. Jensen, and William FenicalView Author Information Scripps Institution of Oceanography, University of CaliforniaSan Diego, La Jolla, California 92093-0236 Cite this: J. Org. Chem. 1996, 61, 4, 1543–1546Publication Date (Web):February 23, 1996Publication History Received2 October 1995Published online23 February 1996Published inissue 1 January 1996https://

A new inhibitor, placotylene A (1), of the receptor activator of nuclear factor-κB ligand (RANKL)-induced osteoclast differentiation, and a regioisomer of placotylene A, placotylene B (2), were isolated from a Korean marine sponge Placospongia sp. The chemical structures of placotylenes A and B were elucidated on the basis of 1D and 2D NMR, along with MS spectral analysis and revealed as an iodinated polyacetylene class of natural products. Placotylene A (1) displayed inhibitory activity against

Intensive study of the organic extract of the marine-derived bacterium <i>Saccharomonospora</i> sp. CNQ-490 has yielded three new α-pyrones, saccharomonopyrones A-C (<b>1</b>-<b>3</b>). The chemical structures of these compounds were assigned from the interpretation of 1D, 2D NMR and mass spectrometry data. Saccharomonopyrone A (<b>1</b>) is the first α-pyrone microbial natural product bearing the ethyl-butyl ether chain in the molecule, while saccharomonopyrones B and C possess unusual 3-methyl

Four new meroterpenoids, austalides V-X (<b>1</b>-<b>3</b>) and a farnesylated phthalide derivative (<b>4</b>), were isolated from the culture of the marine fungus <i>Penicillium rudallense</i>, together with eight known meroterpenoids derivatives (<b>5</b>-<b>12</b>). Their structures, including absolute configurations, were determined by spectroscopic methods. All of the isolated compounds were evaluated for their inhibitory activities on the receptor activator of nuclear factor κB ligand (RAN

Pancreatic cancer, which has an extremely poor prognosis, is one of the most fatal human cancers. Chemotherapy is the main palliative treatment for advanced cancer patients and also plays an indispensable role in postoperative treatments for surgical patients. Therefore, there is an urgent need to develop more innovative anticancer drugs to fight against this fatal disease. Here, we investigate the potential of benzophenone derivatives, obtained from a marine-derived strain of the fungus <i>Pest

Abstract 19-Bromoisoeudistomin U (1) and isoeudistomin U (2), two new dihydro-β-carbolines have been isolated from an undescribed Western Australian ascidian of the genus Eudistoma. The structures of these dihydro-β-carbolines were determined by comprehensive spectral analyses primarily involving 2D NMR.

Osteoporosis is a chronic disease that has become a serious public health problem due to the associated reduction in quality of life and its increasing financial burden. It is known that inhibiting osteoclast differentiation and promoting osteoblast formation prevents osteoporosis. As there is no drug with this dual activity without clinical side effects, new alternatives are needed. Here, we demonstrate that austalide K, isolated from the marine fungus <i>Penicillium rudallenes</i>, has dual ac

A new thiopeptide (micrococcin P3, <b>1</b>) and a known one (micrococcin P1, <b>2</b>) were isolated from the culture broth of a marine-derived strain of <i>Bacillus stratosphericus</i>. The structures of both compounds were elucidated using spectroscopic methods, including extensive 1D and 2D NMR analysis, high resolution mass spectrometry (HRMS), and tandem mass spectrometry. Both compounds exhibited potent antibacterial activities against Gram-positive strains with minimum inhibitory concent