윤혜리 교수

Background and Objectives：We aimed to investigate the association between alanine aminotransferase (ALT)level and metabolic syndrome (MetS) in patients with bipolar disorder. Materials and Method：A total of 151bipolar patients who visited the psychiatric clinic in Seoul National University Hospital and have all measures for the diagnosis of MetS for 2 years were studied. Participants with normal ALT were divided 3 groups according to the tertiles of ALT levels for each gender. Results：Patients w

Purpose: We aimed to evaluate the association between immunoglobulin G (IgG) at birth and late-onset sepsis (LoS) in preterm infants. Methods: Medical records of very-low-birth-weight infants, born at gestational age <28 weeks, between 2013 and 2016, were retrospectively reviewed. Subjects were divided into two groups based on the occurrence of LoS (LoS vs. non-LoS), and IgG levels at 1 day, and at 2 weeks and 4 weeks after birth were investigated. IgG levels, other perinatal factors, and clinic

본 연구는 기존의 항정신병약물을 olanzapine으로 변경하여 복용한 정신분열병 환자들을 대상으로 나이, 몸무게, 병력들을 조사하고, 프로락틴 혈중 농도, LUNSERS, CGI, PA-NSS, AIMS, SAS, BARS를 시행하여 주관적인 성기능 장애에 대한 예측인자를 알아보고자 하였다. 6주간의 연구 기간 동안 주관적인 성기능 장애는 호전된 것으로 평가되었으며, 추체외로 증상의 호전 정도가 이에 대한 종적인 예측인자임을 알 수 있었다. 또한 프로락틴의 표준변화량(프로락틴의 혈중 농도 변화량/기저치의 프로락틴 혈중 농도)도 종적인 예측인자임을 알 수 있었다. 그러나, 다른 히스타민 수용체 차단, 콜린성 수용체의 차단, 아드레날린 수용체의 차단과 성기능 장애와는 뚜렷한 연관성을 보이지 않았다. 성기능 장애는 환자의 삶의 질과 치료 결과에 영향을 끼치는 인자로서 더욱 이러한 부작용에 대한 관심과 평가가 필요할 것으로 생각된다.

Pulmonary alveolar proteinosis (PAP) is a rare disease in children characterized by intra-alveolar accumulation of surfactant proteins, which severely reduces gaseous exchange. Whole lung lavage (WLL) is the preferred technique for the treatment of severe PAP. Herein, we present a pediatric case of PAP treated with WLL. An 11-year-old boy was admitted with the chief complaint of a dry cough lasting 6 months. He developed symptoms of dyspnea on exertion and had difficulty in climbing stairs. He w

Purpose: To evaluate the effects of exclusive breast milk feeding (BMF) on the incidence of necrotizing enterocolitis (NEC) in preterm infants. Methods: All newborn infants, born at <32 weeks of gestation and weighing <1,500 g, admitted to the neonatal intensive care center at Seoul National University Bundang Hospital during the study period, were included. The study was divided into period I: pre-exclusive BMF (January 2010–March 2014) and period II: exclusive BMF (April 2014–December 2016). R

Objective: We assessed the influence of small for gestational age (GA) with placental disorders (SGA-P) and histologic chorioamnionitis (HCA) on the in-hospital outcomes of preterm infants. Methods: Preterm infants with a GA <32 weeks born at Seoul National University Hospital between 2007 and 2014 were included and divided into 4 groups according to the presence of SGA-P and HCA: group 1, SGA-P only; group 2, HCA only; group 3, both SGA-P and HCA; and group 4, no SGA-P or HCA. Multivariate logi