오현정 교수
Hyeon Jeong Oh
서울대학교 · 의학
연구실 소개
오현정 교수의 연구실은 대장암의 예후 예측 생물학적 마커와 종양 미세환경의 분자 기전을 중심으로 연구를 진행하고 있습니다. 특히, POSTN, F. nucleatum, p53, HSP110 등의 생체마커가 암 진행과 치료 반응에 미치는 영향을 분석하며, 마이크로환경의 이질성과 관련된 분자 조절 메커니즘을 규명하고자 합니다. 또한, 미네랄인 zinc이 치아 형성과 뼈 발달에 미치는 영향을 다루며, 세포 신호전달과 발달 조절 경로의 상호작용을 탐구하고 있습니다.
연구 현황
연구 성과 추이
표시된 성과는 수집된 데이터 기준으로 산출되며, 일부 차이가 있을 수 있습니다.
주요 논문
15Our findings suggest that POSTN overexpression in tumor stroma of colorectal cancers could be a possible candidate marker for predicting poor prognosis in patients with colorectal cancers.
Intratumoral F. nucleatum load is a potential prognosticfactor in a non-MSI-high/non-sigmoid/non-rectal cancer subset of stage II/III CRCs treatedwith oxaliplatin-based adjuvant chemotherapy.
p53-mild expression status was found to be an independent prognostic marker in adjuvant FOLFOX-treated patients with stage III and high-risk stage II CRC.
Zinc is trace element essential for diverse metabolic and cellular signaling pathways for the growth, development, and maintenance. Zinc deficiency is involved in bone malformations and oral disease. Mice deficient in zinc transporter Zip13 show connective tissue and skeletal disorders, abnormal incisor teeth, and reduced root dentin formation in the molar teeth and share a morphologically similar phenotype to nuclear factor I-C (NFI-C)-deficient mice. However, the precise function of zinc in NF
The aim of this study is to establish heat shock protein 110 (HSP110) as a prognostic biomarker of colorectal carcinomas (CRCs) with microsatellite instability-high (MSI-H) by considering the intratumoral heterogeneity of HSP110 expression. We performed whole-section immunohistochemistry (IHC) for wild-type HSP110 (HSP110wt) in 164 MSI-H CRCs. The intensity of the HSP110wt expression in tumor cells was semiquantitatively scored (0/1/2/3), and the HSP110wt expression status of each tumor was clas
Hyun-jung Oh, Jung-min Sohn, Sun-young Jung, Bo-eun Kim, Seo-yeoun JI, Joo-hyun Jung, Dae-yong Kim, Hwa-young Youn, Junghee Yoon and Min-cheol Choi. J Vet Clin 2014;31:449-53. https://doi.org/10.17555/ksvc.2014.10.31.5.449
Ureteral jets are the result of a forceful ejection of urine from the vesicoureteral junction into the urinary bladder. By using color Doppler ultrasonography (US), we aimed to identify distinct ureteral jets in dogs, provide insight into ureteral obstruction, and facilitate study of urodynamics and vesicoureteric sphincter function via pulsed Doppler US. Color Doppler US was applied to detect urinary flow from the right ureteral orifices in eight healthy beagles. Under anesthesia, 0.9% saline (
The Cure-GA platform enables rapid evaluation of chemotherapeutic responses using patient-derived tumoroids, providing clinicians with crucial insights for personalized treatment strategies and improving therapeutic outcomes.
In L-AP with pediatric ALL patients, MCSI may correlate with usage of IV narcotics, BUN, and peak amylase levels.
This case underscores the importance of considering Brugada syndrome in patients with unexplained ventricular fibrillation, emphasizing the utility of the flecainide challenge test for accurate diagnosis when characteristic ECG findings are not evident.A multidisciplinary approach, including timely diagnosis, appropriate ICD implantation, and patient education, is critical in managing high-risk occupations to prevent catastrophic outcomes.
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