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김효진 교수

Hyojin Kim

서울대학교 · 생화학·유전·분자생물학

연구실 소개

김효진 교수의 연구실은 면역학적 기전과 합성생물학을 기반으로 노화 관련 질환 및 신경퇴행성 질환의 분자적 메커니즘을 규명하고 있습니다. 특히 TLR4 수용체의 다중 신호전달 경로와 CRISPR 기반 유전자 회로 설계를 통해 질병 조절의 새로운 전략을 모색하고 있으며, 뇌세포 손상에 기여하는 아밀로이드 단백질과 산화 스트레스에 대한 천연 항산화제의 보호 작용에 대해서도 연구하고 있습니다. 이는 신약 타겟 발굴과 맞춤형 치료 전략 개발로 이어지는 핵심 연구 분야입니다.

TLR4 신호전달합성생물학CRISPR 유전자 회로알츠하이머병항산화제

연구 현황

논문 수
153
총 인용 수
1,322
최근 5년 논문
34
주요 분야
생화학·유전·분자생물학

연구 성과 추이

표시된 성과는 수집된 데이터 기준으로 산출되며, 일부 차이가 있을 수 있습니다.

5개년 연도별 논문 게재 수
34총합
2022
2023
2024
2025
2026
5개년 연도별 피인용 수
117총합
20222023202420252026

주요 논문

15
1
논문|인용수 74·2007
Protective Effects of Piceatannol against Beta‐Amyloid–Induced Neuronal Cell Death
Hyo Jin Kim, Ki Won Lee, Hyong Joo Lee
SJR Q1FWCI 1.6Annals of the New York Academy of Sciences

Beta-amyloid (Abeta) is a main component of senile plaques in Alzheimer's disease (AD) that induces neuronal cell death. Since reactive oxygen species (ROS) have been implicated in Abeta-induced neurotoxicity, considerable attention has recently been focused on identifying naturally occurring antioxidative phenolic phytochemicals that are able to decrease ROS levels. Piceatannol (trans-3,4,3',5'-tetrahydroxystilbene), which has a structure homologous to resveratrol, is an anti-inflammatory and a

Geriatrics and GerontologyMedicine
2
논문|인용수 62·2007
Piceatannol attenuates hydrogen-peroxide- and peroxynitrite-induced apoptosis of PC12 cells by blocking down-regulation of Bcl-XL and activation of JNK
Hyo Jin Kim, Ki Won Lee, Mi-Sung Kim, Hyong Joo Lee
SJR Q1FWCI 2.8The Journal of Nutritional Biochemistry
Geriatrics and GerontologyMedicine
3
논문|인용수 54·2005
Effect of magnetic field on the fibronectin adsorption, cell attachment and proliferation on titanium surface
Hyo Jin Kim, Ik Tae Chang, Seong‐Joo Heo, Jai Young Koak, Seong Kyun Kim, Jun Hyeog Jang
SJR Q1FWCI 3.9Clinical Oral Implants ResearchOA

Magnetic fields under 10 mT did not influence FN adsorption on the titanium surface. However, a significant effect was found on cell attachment and proliferation.

Biomedical EngineeringEngineering
4
논문|인용수 43·2016
<i>CAR1</i>deletion by CRISPR/Cas9 reduces formation of ethyl carbamate from ethanol fermentation by<i>Saccharomyces cerevisiae</i>
Young‐Wook Chin, Woo-Kyung Kang, Hae Won Jang, Timothy L. Turner, Hyo Jin Kim
SJR Q2FWCI 1.7Journal of Industrial Microbiology & Biotechnology

Enormous advances in genome editing technology have been achieved in recent decades. Among newly born genome editing technologies, CRISPR/Cas9 is considered revolutionary because it is easy to use and highly precise for editing genes in target organisms. CRISPR/Cas9 technology has also been applied for removing unfavorable target genes. In this study, we used CRISPR/Cas9 technology to reduce ethyl carbamate (EC), a potential carcinogen, which was formed during the ethanol fermentation process by

Molecular BiologyBiochemistry, Genetics and Molecular Biology
5
논문|인용수 42·2006
Streptomyces cheonanensis sp. nov., a novel streptomycete with antifungal activity
Hyo Jin Kim, Sung Chul Lee, Byung Kook Hwang
SJR Q1FWCI 1.2INTERNATIONAL JOURNAL OF SYSTEMATIC AND EVOLUTIONARY MICROBIOLOGY

Actinomycete strain VC-A46T, which exhibits antifungal activity, was isolated from a soil sample collected from Cheonan, Korea. The strain was determined to belong to the genus Streptomyces, based on its morphological and chemotaxonomic characteristics. The cell wall of this strain contained ll-diaminopimelic acid. The predominant fatty acids were iso-C16:0, C16:0 and C16:1 cis 9. The DNA G+C content of strain VC-A46T was 75.5 mol%. Phylogenetic analysis of the 16S rRNA gene sequence of this str

Molecular BiologyBiochemistry, Genetics and Molecular Biology
6
리뷰|인용수 38·2021
Secretome of Stem Cells: Roles of Extracellular Vesicles in Diseases, Stemness, Differentiation, and Reprogramming
Hyo Jin Kim, Gyeongmin Kim, Jihun Lee, Youngseok Lee, Jong‐Hoon Kim
SJR Q1FWCI 1.8Tissue Engineering and Regenerative MedicineOA
Molecular BiologyBiochemistry, Genetics and Molecular Biology
7
리뷰|인용수 28·2013
Combinatorial genetic perturbation to refine metabolic circuits for producing biofuels and biochemicals
Hyo Jin Kim, Timothy L. Turner, Yong‐Su Jin
SJR Q1FWCI 1.8Biotechnology Advances
Molecular BiologyBiochemistry, Genetics and Molecular Biology
8
논문|인용수 24·2023
Improved natural food colorant production in the filamentous fungus Monascus ruber using CRISPR-based engineering
Hye Ree Yoon, Suk Jung Han, Seung Chul Shin, Su Cheong Yeom, Hyo Jin Kim
SJR Q1FWCI 6.4Food Research International
BiotechnologyBiochemistry, Genetics and Molecular Biology
9
논문|인용수 23·2019
Enhanced production of 3-hydroxypropionic acid from glucose and xylose by alleviation of metabolic congestion due to glycerol flux in engineered Escherichia coli
Woong Heo, Jun Hee Kim, Sooah Kim, Kyong Heon Kim, Hyo Jin Kim, Jin‐Ho Seo
SJR Q1FWCI 1.1Bioresource Technology
Molecular BiologyBiochemistry, Genetics and Molecular Biology
10
논문|인용수 21·2019
Improved production of 3-hydroxypropionic acid in engineered Escherichia coli by rebalancing heterologous and endogenous synthetic pathways
Tae Young Lee, Won‐Ki Min, Hyo Jin Kim, Jin‐Ho Seo
SJR Q1FWCI 0.8Bioresource Technology
Molecular BiologyBiochemistry, Genetics and Molecular Biology
11
논문|인용수 18·2014
Pyrosequencing analysis of microbiota reveals that lactic acid bacteria are dominant in Korean flat fish fermented food,<i>gajami</i>-<i>sikhae</i>
Hyo Jin Kim, Min-Jeong Kim, Timothy L. Turner, Bong Soo Kim, Kyung‐Mo Song, Sung-Hun Yi, Myung-Ki Lee
SJR Q3FWCI 2.7Bioscience Biotechnology and BiochemistryOA

The gajami-sikhae, traditional Korean cuisine fermented with flat fish, samples were collected from eight different manufacturers (GS1-GS8). We employed pyrosequencing method to analyze the bacterial communities of the gajami-sikhae samples. Family- and genus-level analyses indicated that the bacterial community compositions of GS3 and GS6 were distinct from those of the rest. The species-level structures of bacterial communities of the gajami-sikhae samples except for GS3 and GS6 featured Lacto

Food ScienceAgricultural and Biological Sciences
12
논문|인용수 16·2017
Arm Motion Estimation Algorithm Using MYO Armband
Hyo Jin Kim, Ye Sol Lee, Donghan Kim
FWCI 1.0

In this paper, we proposes an algorithm to estimate the overall arm motion using the MYO armband attached to the upper arm. Thus, we can get EMG data of biceps brachii and triceps brachii when the human stretch or bend his/her arm. The motion of the lower arm is estimated through the EMG signal of the upper arm. The motion of the upper arm is detected through the IMU sensor. To increase the reliability of the data, experimental environment is set up and process of filtering and initialization ar

Biomedical EngineeringEngineering
13
논문|인용수 16·2013
Investigation of protein expression profiles of erythritol-producing Candida magnoliae in response to glucose perturbation
Hyo Jin Kim, Hyeong-Rho Lee, Chang Sup Kim, Yong‐Su Jin, Jin‐Ho Seo
SJR Q2FWCI 0.9Enzyme and Microbial Technology
Molecular BiologyBiochemistry, Genetics and Molecular Biology
14
논문|인용수 13·2010
Expression of PAT and NPT II Proteins during the Developmental Stages of a Genetically Modified Pepper Developed in Korea
Hyo Jin Kim, Si Myung Lee, Jae Kwang Kim, Tae Hun Ryu, Seok Cheol Suh, Hyun Suk Cho
SJR Q1FWCI 2.5Journal of Agricultural and Food Chemistry

Estimation of the protein levels introduced in a biotechnology-derived product is conducted as part of an overall safety assessment. An enzyme-linked immunosorbent assay (ELISA) was used to analyze phosphinothricin acetyltransferase (PAT) and neomycin phosphotransferase II (NPT II) protein expression in a genetically modified (GM) pepper plant developed in Korea. PAT and NPT II expression levels, based on both dry weight and fresh weight, were variable among different plant generations and plant

Plant ScienceAgricultural and Biological Sciences
15
논문|인용수 13·2009
소아 청소년 정신건강 선별검사 및 치료 연계 효율성에 대한 연구:지역사회 중심 연구
김효진, 조수철, 김재원, 강제욱, 신민섭, 윤명주, 이경영, 강연주, 김붕년, 김효원

Objectives:This study evaluated the effectiveness of school-based mental health screening and treatment linkage programs, focusing on attention-deficit hyperactivity disorder (ADHD) and adolescent depression. Methods:All 11,158 children and adolescents aged 8-14 years in Seoul received a school-based mental health screening, consisting of the Korean versions of the ADHD rating scale and the Child Behavior Checklist (CBCL), for ADHD, and the Center for Epidemiological Studies Depression Scale (CE

대표 연구 분야

Molecular BiologyBiomedical EngineeringBiotechnologyFood ScienceGeriatrics and GerontologyPlant Science

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