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Hyow-Jung Lee

Seoul National University · 医学

研究室紹介

Professor Hyow-Jung Lee's research lab specializes in microbial ecology and host-microbe interactions, with a focus on understanding the roles of methanotrophs and methanogens in anaerobic environments such as rice paddies and ruminant digestive systems. The lab integrates molecular microbiology, high-throughput sequencing (e.g., 16S rRNA gene pyrosequencing), and metabolomics to explore microbial community dynamics, methane cycling, and metabolic interactions in agricultural and host-associated ecosystems. Additional research explores the metabolic links between adipocytes and insulin resistance, as well as the bioactive compounds in traditional medicinal plants and their antiangiogenic properties.

methanotrophsmicrobial ecologymetabolomicsruminant microbiotainsulin resistance

Research Overview

Papers
403
Total Citations
12,450
Papers (5y)
88
Primary Field
医学

Research Output Trend

Figures are computed from collected data and may differ slightly.

Publications per year (5y)
88total
2021
2022
2023
2024
2025
Citations per year (5y)
2,037total
20212022202320242025

Selected Papers

15
1
Article|183 citations·2008
Rosmarinic acid protects human dopaminergic neuronal cells against hydrogen peroxide-induced apoptosis
Hyo‐Jung Lee, Hong-Suk Cho, Euteum Park, Seung Kim, Sook‐Young Lee, Chun‐Sung Kim, Do Kyung Kim, Sungjun Kim, Hong Sung Chun
SJR Q1FWCI 2.3Toxicology
Molecular BiologyBiochemistry, Genetics and Molecular Biology
2
Article|153 citations·2015
High resolution depth distribution of Bacteria, Archaea, methanotrophs, and methanogens in the bulk and rhizosphere soils of a flooded rice paddy
Hyo‐Jung Lee, Sang Eun Jeong, Pil Joo Kim, Eugene L. Madsen, Che Ok Jeon
SJR Q1FWCI 11.9Frontiers in MicrobiologyOA

The communities and abundances of methanotrophs and methanogens, along with the oxygen, methane, and total organic carbon (TOC) concentrations, were investigated along a depth gradient in a flooded rice paddy. Broad patterns in vertical profiles of oxygen, methane, TOC, and microbial abundances were similar in the bulk and rhizosphere soils, though methane and TOC concentrations and 16S rRNA gene copies were clearly higher in the rhizosphere soil than in the bulk soil. Oxygen concentrations decr

Environmental ChemistryEnvironmental Science
3
Article|144 citations·2014
Methane emission and dynamics of methanotrophic and methanogenic communities in a flooded rice field ecosystem
Hyo‐Jung Lee, Sang-Yoon Kim, Pil Joo Kim, Eugene L. Madsen, Che Ok Jeon
SJR Q1FWCI 8.7FEMS Microbiology EcologyOA

Methane emissions, along with methanotrophs and methanogens and soil chemical properties, were investigated in a flooded rice ecosystem. Methane emission increased after rice transplantation (from 7.2 to 552 mg day(-1) m(-2) ) and was positively and significantly correlated with transcripts of pmoA and mcrA genes, transcript/gene ratios of mcrA, temperature and total organic carbon. Methane flux was negatively correlated with sulfate concentration. Methanotrophs represented only a small proporti

Environmental ChemistryEnvironmental Science
4
Article|141 citations·2012
Comparative Survey of Rumen Microbial Communities and Metabolites across One Caprine and Three Bovine Groups, Using Bar-Coded Pyrosequencing and <sup>1</sup> H Nuclear Magnetic Resonance Spectroscopy
Hyo‐Jung Lee, Ji Young Jung, Young Kyoon Oh, Sang‐Suk Lee, Eugene L. Madsen, Che Ok Jeon
SJR Q1FWCI 20.8Applied and Environmental MicrobiologyOA

Pyrosequencing of 16S rRNA genes (targeting Bacteria and Archaea) and (1)H nuclear magnetic resonance were applied to investigate the rumen microbiota and metabolites of Hanwoo steers in the growth stage (HGS), Hanwoo steers in the late fattening stage (HFS), Holstein-Friesian dairy cattle (HDC), and Korean native goats (KNG) in the late fattening stage. This was a two-part investigation. We began by comparing metabolites and microbiota of Hanwoo steers at two stages of husbandry. Statistical co

Agronomy and Crop ScienceAgricultural and Biological Sciences
5
Article|109 citations·2008
Mitochondria-cytochrome C-caspase-9 cascade mediates isorhamnetin-induced apoptosis
Hyo‐Jung Lee, Hyo‐Jeong Lee, Eun‐Ok Lee, Seong‐Gyu Ko, Hyunsoo Bae, Cheol‐Ho Kim, Kyoo-Seok Ahn, Junxuan Lü, Sung‐Hoon Kim
SJR Q1FWCI 11.2Cancer Letters
Complementary and alternative medicineMedicine
6
Article|76 citations·2008
Shikonin, Acetylshikonin, and Isobutyroylshikonin Inhibit VEGF-induced Angiogenesis and Suppress Tumor Growth in Lewis Lung Carcinoma-bearing Mice
Hyo‐Jung Lee, Hyo‐Jeong Lee, V. Magesh, Dongwoo Nam, Eun‐Ok Lee, Kwang Seok Ahn, Min‐Hyung Jung, Kyoo-Seok Ahn, Daekeun Kim, Jiyoung Kim, Sung‐Hoon Kim
SJR Q3FWCI 4.0YAKUGAKU ZASSHIOA

Lithospermum erythrorhizon has been used for treatment of inflammatory diseases and cancer as a folk remedy. Based on the evidences that anti-inflammatory agents frequently exert antiangiogenic activity, thus we examined comparatively the antiangiogenic activities of three naphthoquinone derivatives (shikonin, acetylshikonin, and isobutyroylshikonin) isolated from the plant. Three derivatives exhibited weak cytotoxicity against human umbilical vein endothelial cells (HUVECs) with IC50 of over 20

ToxicologyPharmacology, Toxicology and Pharmaceutics
7
Article|62 citations·2019
2-Aminoadipic acid (2-AAA) as a potential biomarker for insulin resistance in childhood obesity
Hyo‐Jung Lee, Han Byul Jang, Won–Ho Kim, Keon Jae Park, Kwang-Youl Kim, Sang Ick Park, Hye Ja Lee
SJR Q1FWCI 3.5Scientific ReportsOA

Insulin resistance is an important clinical feature of metabolic syndrome, which includes obesity and type 2 diabetes. Increased adipose energy storage in obesity promote insulin resistance and other metabolic adverse effects. To identify a new link between adipocyte and insulin resistance, we performed targeted metabolite profiling of differentiated adipocytes and studied the association between adipogenic metabolites and insulin resistance. We found a correlation between 2-aminoadipic acid (2-

PhysiologyMedicine
8
Article|60 citations·2015
Effect of excess iron on oxidative stress and gluconeogenesis through hepcidin during mitochondrial dysfunction
Hyo‐Jung Lee, Joo Sun Choi, Hye Ja Lee, Won–Ho Kim, Sang Ick Park, Jihyun Song
SJR Q1FWCI 4.0The Journal of Nutritional Biochemistry
HematologyMedicine
9
Article|56 citations·2006
The Association Between Cumulative Periodontal Disease and Stroke History in Older Adults
Hyo‐Jung Lee, Raul I. García, Sok‐Ja Janket, Judith A. Jones, Ana Karina Mascarenhas, Thayer E. Scott, Martha E. Nunn
SJR Q1FWCI 3.2Journal of Periodontology

Based on the results of this study, there is evidence of an association between cumulative periodontal disease, based on PHS, and a history of stroke. However, it is unclear whether cumulative periodontal disease is an independent risk factor for stroke or a risk marker for the disease.

PeriodonticsDentistry
10
Article|47 citations·2005
Cambodian Phellinus linteus Inhibits Experimental Metastasis of Melanoma Cells in Mice via Regulation of Urokinase Type Plasminogen Activator
Hyo‐Jung Lee, Hyo‐Jeong Lee, Eu-Soo Lim, Kyoo-Seok Ahn, Beom-Sang Shim, Hyung‐Min Kim, Soo-Ja Gong, Daekeun Kim, Sung‐Hoon Kim
SJR Q2FWCI 2.5Biological and Pharmaceutical BulletinOA

Phellinus linteus (PL) is a fungus mainly found in tropical America, Africa and Asian countries including Korea, Japan and China. PL has been traditionally used for the treatment of arthritis, liver damage and cancer. However, little was known on the biological activity and characterization of Phellinus species in Cambodia. Thus, in the present study, the anti-metastatic mechanism of aqueous extract of Cambodian Phellinus linteus (CPL) was evaluated. Cambodian mushroom was identified as a Phelli

PharmacologyMedicine
11
Article|47 citations·2012
Gallotannin Suppresses Calcium Oxalate Crystal Binding and Oxalate-Induced Oxidative Stress in Renal Epithelial Cells
Hyo‐Jung Lee, Soo-Jin Jeong, Moon Nyeo Park, Michael Linnes, Hee Jeoung Han, Jin Hyoung Kim, John C. Lieske, Sung‐Hoon Kim
SJR Q2FWCI 3.2Biological and Pharmaceutical BulletinOA

Calcium oxalate monohydrate (COM) crystals bind avidly to the surface of proliferating and migrating renal endothelial cells, perhaps a key event in kidney stone formation. Oxalate-induced pre-oxidative stress can further promote crystal attachment cells. Natural products including gallotannins found in green teas have been studied as potentially novel treatments to prevent crystal retention and kidney stone formation. Gallotannin significantly inhibited COM crystal growth and binding to Madin-D

Pulmonary and Respiratory MedicineMedicine
12
Article|45 citations·2018
Cloning, purification, and characterization of an organic solvent-tolerant chitinase, MtCh509, from Microbulbifer thermotolerans DAU221
Hyo‐Jung Lee, Yong-Suk Lee, Yong‐Lark Choi
FWCI 2.4Biotechnology for BiofuelsOA

The results of the hydrolysate analysis and the observed increase in enzyme activity in the presence of organic solvents show that MtCh509 has industrially attractive advantages. This is the first report on an organic solvent-tolerant and transglycosylating chitinase from <i>Microbulbifer</i> species.

Molecular BiologyBiochemistry, Genetics and Molecular Biology
13
Article|41 citations·2015
Microgrooves on titanium surface affect peri-implant cell adhesion and soft tissue sealing; an <i>in vitro</i> and <i>in vivo</i> study
Hyo‐Jung Lee, Jaden S. Lee, Jung‐Tae Lee, Jisoo Hong, Bum‐Soon Lim, Hee‐Jung Park, Young K. Kim, Tae‐Il Kim
SJR Q1FWCI 5.0Journal of Periodontal & Implant ScienceOA

Microgrooves on the titanium surface promoted the adhesion of gingival fibroblasts and osteoblastic cells, as well as favorable peri-implant soft tissue sealing.

Oral SurgeryDentistry
14
Article|41 citations·2010
1,2,3,4,6-Penta-O-galloyl-beta-D-glucose reduces renal crystallization and oxidative stress in a hyperoxaluric rat model
Hyo‐Jung Lee, Soo‐Jin Jeong, Hyo‐Jeong Lee, Eun‐Ok Lee, Hyunsu Bae, John C. Lieske, Sung‐Hoon Kim
SJR Q1FWCI 2.6Kidney InternationalOA
Pulmonary and Respiratory MedicineMedicine
15
Article|36 citations·2010
Short-term clinical retrospective study of implants in geriatric patients older than 70 years
Hyo‐Jung Lee, Young‐Kyun Kim, Jin-Young Park, Su-Gwan Kim, Myung‐Jin Kim, Pil‐Young Yun
FWCI 2.8Oral Surgery Oral Medicine Oral Pathology Oral Radiology and Endodontology
Oral SurgeryDentistry

Research Areas

Molecular BiologyOral SurgeryOncologyPharmacologyPeriodonticsCancer Research

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