Sungkyunkwan University · 医学
Professor Hyun Soo Kim's research lab focuses on understanding the molecular and metabolic mechanisms underlying cancer development and stem cell biology. The lab investigates oncogenic drivers in glioblastoma through integrated multi-omics analysis, identifying key microRNAs like miR-26a and their roles in tumorigenesis via regulation of tumor suppressors and signaling pathways. It also explores the metabolic reprogramming essential for pluripotent stem cell maintenance, particularly the direct regulation of glycolytic enzymes by core transcription factors. Additionally, the lab examines the pathological and molecular features of biliary tract cancers, especially gallbladder carcinoma, with an emphasis on biomarker discovery and disease progression.
Figures are computed from collected data and may differ slightly.
Using a multidimensional genomic data set on glioblastoma from The Cancer Genome Atlas, we identified hsa-miR-26a as a cooperating component of a frequently occurring amplicon that also contains CDK4 and CENTG1, two oncogenes that regulate the RB1 and PI3 kinase/AKT pathways, respectively. By integrating DNA copy number, mRNA, microRNA, and DNA methylation data, we identified functionally relevant targets of miR-26a in glioblastoma, including PTEN, RB1, and MAP3K2/MEKK2. We demonstrate that miR-
Pluripotent stem cells (PSCs) have distinct metabolic properties that support their metabolic and energetic needs and affect their stemness. In particular, high glycolysis is critical for the generation and maintenance of PSCs. However, it is unknown how PSCs maintain and acquire this metabolic signature. In this study, we found that core pluripotency factors regulate glycolysis directly by controlling the expression of glycolytic enzymes. Specifically, Oct4 directly governs Hk2 and Pkm2, which
Gallbladder carcinoma is the most common malignancy of the biliary tract in Korea and known to be more common in East Asia and Latin America than in Europe and North America. However, their exact histopathological characteristics and carcinogenesis are not well-elucidated. A total of 71 cases of gallbladder carcinomas, two cases of gallbladder dysplasia and 20 cases of gallbladder adenoma were immunohistochemically studied to evaluate the expression of c-erb-B2 and p53 proteins in the light of t
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