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이현숙 교수

Hyun-sook Lee

서울대학교 생명과학부 · 생화학·유전·분자생물학

연구실 소개

이현숙 교수의 연구실은 식물 유전자 기능 해석과 발달 생물학을 중심으로, 특히 꽃가루 발달에 관여하는 수용체 키나제(PRK1)의 기능을 규명하는 데 초점을 맞추고 있습니다. 또한 벼의 씨앗발생을 위한 메소코틸 길이 조절 유전자를 규명하고, 이와 관련된 QTL 분석 및 정밀 맵핑을 통해 농업적 중요성 높은 형질의 유전적 기반을 규명하고 있습니다. 최근에는 나노소재 기반의 수소 저장 복합체 개발 및 환경 행동 연구를 통해 에너지 및 환경 분야의 다학제적 연구도 진행하고 있습니다.

식물 유전자 기능메소코틸 길이수소 저장 복합체환경 행동유전자 맵핑

연구 현황

논문 수
259
총 인용 수
4,636
최근 5년 논문
45
주요 분야
생화학·유전·분자생물학

연구 성과 추이

표시된 성과는 수집된 데이터 기준으로 산출되며, 일부 차이가 있을 수 있습니다.

5개년 연도별 논문 게재 수
45총합
2022
2023
2024
2025
2026
5개년 연도별 피인용 수
143총합
20222023202420252026

주요 논문

15
1
논문|인용수 235·1999
Mitotic Checkpoint Inactivation Fosters Transformation in Cells Lacking the Breast Cancer Susceptibility Gene, Brca2
Hyun‐Sook Lee, Alison Trainer, Lori S. Friedman, Fiona Thistlethwaite, Martin Evans, Bruce A.J. Ponder, Ashok R. Venkitaraman
SJR Q1FWCI 12.1Molecular CellOA
Molecular BiologyBiochemistry, Genetics and Molecular Biology
2
논문|인용수 213·2002
A Dominant-Negative Form of p63 Is Required for Epidermal Proliferation in Zebrafish
Hyun‐Sook Lee, David Kimelman
SJR Q1FWCI 4.3Developmental CellOA
OncologyMedicine
3
논문|인용수 83·1996
PRK1, a receptor‐like kinase of <i>Petunia inflata</i>, is essential for postmeiotic development of pollen
Hyun‐Sook Lee, Balasulojini Karunanandaa, Andrew G. McCubbin, Simon Gilroy, Teh‐hui Kao
SJR Q1FWCI 2.5The Plant JournalOA

Summary A pollen‐expressed gene of Petunia inflata that encodes a receptor‐like kinase named PRK1 was previously identified. The extracellular domain of PRK1 contains leucine‐rich repeats which have been implicated in protein—protein interactions, and the cytoplasmic domain was found to autophosphorylate on serine and possibly tyrosine. To investigate the function of PRK1 in pollen development, P. inflata plants were transformed with a construct containing the promoter of a pollen‐expressed gene

Molecular BiologyBiochemistry, Genetics and Molecular Biology
4
논문|인용수 70·2012
Mapping and characterization of quantitative trait loci for mesocotyl elongation in rice (Oryza sativa L.)
Hyun‐Sook Lee, Kazuhiro Sasaki, Atsushi Higashitani, Sang-Nag Ahn, Tadashi Sato
SJR Q1FWCI 1.9RiceOA

Mesocotyl elongation is an important trait for seedling emergence in direct-seeding cultivation in rice. In this study, a backcross inbred line (BIL) population from a cross between Kasalath and Nipponbare was employed to map quantitative trait loci (QTLs) for mesocotyl elongation. A total of 5 QTLs for mesocotyl length were identified on chromosomes 1, 3, 7, 9, and 12 in 2 independent experiments. At all QTL, the Kasalath alleles contributed to an increase in mesocotyl length. Two QTLs (qMel-1

GeneticsBiochemistry, Genetics and Molecular Biology
5
논문|인용수 68·2007
Comparative studies on the diversity of the edible mushroom Pleurotus eryngii: ITS sequence analysis, RAPD fingerprinting, and physiological characteristics
Hyeon‐Su Ro, So Yoon Kim, Jae-San Ryu, Che Ok Jeon, Tae Soo Lee, Hyun‐Sook Lee
FWCI 3.3Mycological Research
PharmacologyMedicine
6
논문|인용수 60·2003
Characterization of a novel single-stranded RNA mycovirus in pleurotus ostreatus
Hyun Jae Yu, Dongbin Lim, Hyun‐Sook Lee
SJR Q2FWCI 2.2Virology
EndocrinologyBiochemistry, Genetics and Molecular Biology
7
논문|인용수 54·2011
Enhanced Desorption and Absorption Properties of Eutectic LiBH<sub>4</sub>–Ca(BH<sub>4</sub>)<sub>2</sub> Infiltrated into Mesoporous Carbon
Hyun‐Sook Lee, Young‐Su Lee, Jin‐Yoo Suh, Minwoo Kim, Jong‐Sung Yu, Young Whan Cho
SJR Q1FWCI 2.4The Journal of Physical Chemistry C

We present enhanced hydrogen storage properties of the eutectic LiBH4–Ca(BH4)2 composite confined inside a mesoporous carbon scaffold via melt infiltration. The eutectic composition was examined by analyzing the enthalpy of fusion as a function of the LiBH4-to-Ca(BH4)2 ratio. Elemental analysis by energy dispersive X-ray spectroscopy and phase analysis by X-ray diffraction patterns provided both direct and indirect evidence for the infiltration of the LiBH4–Ca(BH4)2 composite into the mesoporous

Materials ChemistryMaterials Science
8
논문|인용수 47·2013
Influential Factors on Pro-Environmental Behaviors—A Case Study in Tokyo and Seoul
Hyun‐Sook Lee, Kiyo Kurisu, Keisuke Hanaki
FWCI 6.1Low Carbon EconomyOA

To develop the low-carbon society, in addition to the efforts by industrial and commercial sectors, promotion of people’s pro-environmental behaviors (PEBs) has become one of the key issues. Some PEBs have been investigated in previous studies, however, the targets were limited to particular behaviors (i.e., recycling, water saving, electricity saving). The holistic view of understanding the characteristics of PEBs has remained insufficient. In this study, we selected 58 daily PEBs from various

Management, Monitoring, Policy and LawEnvironmental Science
9
논문|인용수 45·1996
Crystal Structures of <i>Escherichia coli</i> Dihydrofolate Reductase Complexed with 5-Formyltetrahydrofolate (Folinic Acid) in Two Space Groups:  Evidence for Enolization of Pteridine O4<sup>,</sup>
Hyun‐Sook Lee, Vicente M. Reyes, Joseph Kraut
SJR Q1FWCI 0.5Biochemistry

The crystal structure of Escherichia coli dihydrofolate reductase (ecDHFR, EC 1.5.1.3) as a binary complex with folinic acid (5-formyl-5,6,7,8-tetrahydrofolate; also called leucovorin or citrovorum factor) has been solved in two space groups, P6(1) and P6(5), with, respectively, two molecules and one molecule per asymmetric unit. The crystal structures have been refined to an R-factor of 14.2% at resolutions of 2.0 and 1.9 A. The P6(1) structure is isomorphous with several previously reported ec

Molecular BiologyBiochemistry, Genetics and Molecular Biology
10
논문|인용수 38·1995
X-gene Product Antagonizes the p53-mediated Inhibition of Hepatitis B Virus Replication through Regulation of the Pregenomic/Core Promoter
Hyun‐Sook Lee, Young‐Ho Lee, Yunsil Huh, H R Moon, Yungdae Yun
SJR Q1FWCI 2.9Journal of Biological ChemistryOA

Employing the glutathione S-transferase column retention method and far Western analysis, we found a physical association between tumor suppressor p53 and the hepatitis B virus X-gene product, which led us to study the function of observed interaction in relation to viral propagation. In the cell culture-based in vitro replication system, expression of p53 resulted in dramatic inhibition of viral replication, and this inhibition was relieved by the coexpression of the X-gene product in a dose-de

EpidemiologyMedicine
11
논문|인용수 34·2006
A dominant negative form of p63 inhibits apoptosis in a p53-independent manner
Hae‐Ock Lee, Hae‐Ock Lee, Jung-Hwa Lee, Eunhee Choi, Ja Young Seol, Yungdae Yun, Hyun‐Sook Lee, Hyun‐Sook Lee
SJR Q2FWCI 1.7Biochemical and Biophysical Research Communications
OncologyMedicine
12
논문|인용수 32·2010
Inhibition of Plk1 induces mitotic infidelity and embryonic growth defects in developing zebrafish embryos
KilHun Jeong, Jaeyeon Jeong, Hae‐Ock Lee, Hae‐Ock Lee, Eunhee Choi, Hyun‐Sook Lee, Hyun‐Sook Lee
SJR Q2FWCI 1.7Developmental Biology
Cell BiologyBiochemistry, Genetics and Molecular Biology
13
리뷰|인용수 29·2014
Cycling with BRCA2 from DNA repair to mitosis
Hyun‐Sook Lee
SJR Q2FWCI 1.4Experimental Cell ResearchOA

Genetic integrity in proliferating cells is guaranteed by the harmony of DNA replication, appropriate DNA repair, and segregation of the duplicated genome. Breast cancer susceptibility gene BRCA2 is a unique tumor suppressor that is involved in all three processes. Hence, it is critical in genome maintenance. The functions of BRCA2 in DNA repair and homology-directed recombination (HDR) have been reviewed numerous times. Here, I will briefly go through the functions of BRCA2 in HDR and focus on

Molecular BiologyBiochemistry, Genetics and Molecular Biology
14
논문|인용수 28·2017
Knowledge Management Enablers and Process in Hospital Organizations
Hyun‐Sook Lee
SJR Q3FWCI 4.7Osong Public Health and Research PerspectivesOA

From a managerial perspective, the implications of these factors for developing organizational strategies that encourage and foster the knowledge management process are discussed.

CommunicationSocial Sciences
15
논문|인용수 28·2012
Prognostic Value of Alternative Lengthening of Telomeres-Associated Biomarkers in Uterine Sarcoma and Uterine Carcinosarcoma
Yoo‐Kyung Lee, Noh-Hyun Park, Hyun‐Sook Lee
SJR Q1FWCI 1.0International Journal of Gynecological Cancer
PhysiologyMedicine

대표 연구 분야

Molecular BiologyGeneticsCell BiologyMaterials ChemistryPlant ScienceEndocrinology

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