이현숙 교수
Hyun-sook Lee
서울대학교 생명과학부 · 생화학·유전·분자생물학
연구실 소개
이현숙 교수의 연구실은 식물 유전자 기능 해석과 발달 생물학을 중심으로, 특히 꽃가루 발달에 관여하는 수용체 키나제(PRK1)의 기능을 규명하는 데 초점을 맞추고 있습니다. 또한 벼의 씨앗발생을 위한 메소코틸 길이 조절 유전자를 규명하고, 이와 관련된 QTL 분석 및 정밀 맵핑을 통해 농업적 중요성 높은 형질의 유전적 기반을 규명하고 있습니다. 최근에는 나노소재 기반의 수소 저장 복합체 개발 및 환경 행동 연구를 통해 에너지 및 환경 분야의 다학제적 연구도 진행하고 있습니다.
연구 현황
연구 성과 추이
표시된 성과는 수집된 데이터 기준으로 산출되며, 일부 차이가 있을 수 있습니다.
주요 논문
15Summary A pollen‐expressed gene of Petunia inflata that encodes a receptor‐like kinase named PRK1 was previously identified. The extracellular domain of PRK1 contains leucine‐rich repeats which have been implicated in protein—protein interactions, and the cytoplasmic domain was found to autophosphorylate on serine and possibly tyrosine. To investigate the function of PRK1 in pollen development, P. inflata plants were transformed with a construct containing the promoter of a pollen‐expressed gene
Mesocotyl elongation is an important trait for seedling emergence in direct-seeding cultivation in rice. In this study, a backcross inbred line (BIL) population from a cross between Kasalath and Nipponbare was employed to map quantitative trait loci (QTLs) for mesocotyl elongation. A total of 5 QTLs for mesocotyl length were identified on chromosomes 1, 3, 7, 9, and 12 in 2 independent experiments. At all QTL, the Kasalath alleles contributed to an increase in mesocotyl length. Two QTLs (qMel-1
We present enhanced hydrogen storage properties of the eutectic LiBH4–Ca(BH4)2 composite confined inside a mesoporous carbon scaffold via melt infiltration. The eutectic composition was examined by analyzing the enthalpy of fusion as a function of the LiBH4-to-Ca(BH4)2 ratio. Elemental analysis by energy dispersive X-ray spectroscopy and phase analysis by X-ray diffraction patterns provided both direct and indirect evidence for the infiltration of the LiBH4–Ca(BH4)2 composite into the mesoporous
To develop the low-carbon society, in addition to the efforts by industrial and commercial sectors, promotion of people’s pro-environmental behaviors (PEBs) has become one of the key issues. Some PEBs have been investigated in previous studies, however, the targets were limited to particular behaviors (i.e., recycling, water saving, electricity saving). The holistic view of understanding the characteristics of PEBs has remained insufficient. In this study, we selected 58 daily PEBs from various
The crystal structure of Escherichia coli dihydrofolate reductase (ecDHFR, EC 1.5.1.3) as a binary complex with folinic acid (5-formyl-5,6,7,8-tetrahydrofolate; also called leucovorin or citrovorum factor) has been solved in two space groups, P6(1) and P6(5), with, respectively, two molecules and one molecule per asymmetric unit. The crystal structures have been refined to an R-factor of 14.2% at resolutions of 2.0 and 1.9 A. The P6(1) structure is isomorphous with several previously reported ec
Employing the glutathione S-transferase column retention method and far Western analysis, we found a physical association between tumor suppressor p53 and the hepatitis B virus X-gene product, which led us to study the function of observed interaction in relation to viral propagation. In the cell culture-based in vitro replication system, expression of p53 resulted in dramatic inhibition of viral replication, and this inhibition was relieved by the coexpression of the X-gene product in a dose-de
Genetic integrity in proliferating cells is guaranteed by the harmony of DNA replication, appropriate DNA repair, and segregation of the duplicated genome. Breast cancer susceptibility gene BRCA2 is a unique tumor suppressor that is involved in all three processes. Hence, it is critical in genome maintenance. The functions of BRCA2 in DNA repair and homology-directed recombination (HDR) have been reviewed numerous times. Here, I will briefly go through the functions of BRCA2 in HDR and focus on
From a managerial perspective, the implications of these factors for developing organizational strategies that encourage and foster the knowledge management process are discussed.
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