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최인실 교수

In Sil Choi

서울대학교 · 의학

연구실 소개

최인실 교수의 연구실은 소재의학 및 정밀의료 분야에서 활동하며, 특히 암 치료의 개인화와 비침습적 진단 기술 개발에 초점을 맞추고 있습니다. 전이성 위암, 대장암 등 고형암 환자 대상으로 순환 종양 DNA(ceDNA) 분석, 유전자 프로파일링, 그리고 치료 반응 예측 지표 개발을 통해 실생활 임상 적용이 가능한 연구를 진행하고 있습니다. 특히, 21유전자 리스크 스코어, ctDNA 동적 변화, 화학요법 반응 예측 등에서 실증적 데이터를 확보하며 정밀의료의 실현 가능성을 탐색하고 있습니다.

순환 종양 DNA유전자 프로파일링정밀의료암 치료 반응 예측비침습적 진단

연구 현황

논문 수
140
총 인용 수
2,537
최근 5년 논문
49
주요 분야
의학

연구 성과 추이

표시된 성과는 수집된 데이터 기준으로 산출되며, 일부 차이가 있을 수 있습니다.

5개년 연도별 논문 게재 수
49총합
2021
2022
2023
2024
2025
5개년 연도별 피인용 수
214총합
20212022202320242025

주요 논문

15
1
논문|인용수 59·2021
A randomised phase II study of oxaliplatin/5-FU (mFOLFOX) versus irinotecan/5-FU (mFOLFIRI) chemotherapy in locally advanced or metastatic biliary tract cancer refractory to first-line gemcitabine/cisplatin chemotherapy
In Sil Choi, Ki Hwan Kim, Ju Hyun Lee, Koung Jin Suh, Ji‐Won Kim, Jin Hyun Park, Yu Jung Kim, Jin-Soo Kim, Jee Hyun Kim, Jin Won Kim
SJR Q1FWCI 8.2European Journal of Cancer
SurgeryMedicine
2
논문|인용수 42·2018
Treatment patterns and outcomes in patients with metastatic gastric cancer receiving third-line chemotherapy: A population-based outcomes study
In Sil Choi, Mihong Choi, Ju Hyun Lee, Jee Hyun Kim, Koung Jin Suh, Ji Yun Lee, Beodeul Kang, Ji‐Won Kim, Se Hyun Kim, Jin Won Kim, Jeong‐Ok Lee, Yu Jung Kim
SJR Q1FWCI 3.1PLoS ONEOA

In patients with MGC receiving third-line chemotherapy, TF1T3 was the only significant factor associated with OS. The sequence of using taxane and irinotecan as subsequent therapy after first-line failure was not shown to impact survival outcome.

Pulmonary and Respiratory MedicineMedicine
3
논문|인용수 33·2020
Association Between Fatty Liver Index and Risk of Breast Cancer: A Nationwide Population-Based Study
Jin Hyun Park, In Sil Choi, Kyungdo Han, Hyunkyung Park, Ki Hwan Kim, Jin-Soo Kim
SJR Q2FWCI 3.1Clinical Breast Cancer
EpidemiologyMedicine
4
논문|인용수 29·2002
Efficacy of modified regimen with attenuated doses of paclitaxel plus carboplatin combination chemotherapy in elderly and/or weak patients with advanced non-small cell lung cancer
In Sil Choi, Byung Su Kim, Sook Ryun Park, Sang Yoon Lee, Do Yeun Kim, Jee Hyun Kim, Se‐Hoon Lee, Tae‐You Kim, Dae Seog Heo, Yung‐Jue Bang, Noe Kyeong Kim
SJR Q1FWCI 2.1Lung Cancer
Pulmonary and Respiratory MedicineMedicine
5
논문|인용수 27·2007
Oxaliplatin, 5-FU, Folinic Acid as First-line Palliative Chemotherapy in Elderly Patients with Metastatic or Recurrent Gastric Cancer
In Sil Choi, Do‐Youn Oh, Byoung-Su Kim, Keun‐Wook Lee, Jee Hyun Kim, Jong-Seok Lee
SJR Q1FWCI 1.5Cancer Research and TreatmentOA

This oxaliplatin/5-FU/FA regimen showed good efficacy and an acceptable toxicity profile in elderly patients with metastatic or recurrent gastric cancer.

Pulmonary and Respiratory MedicineMedicine
6
논문|인용수 24·2019
Genomic Profiling of Blood-Derived Circulating Tumor DNA from Patients with Colorectal Cancer: Implications for Response and Resistance to Targeted Therapeutics
In Sil Choi, Shumei Kato, Paul T. Fanta, Lawrence Leichman, Ryosuke Okamura, Victoria M. Raymond, Richard B. Lanman, Scott M. Lippman, Razelle Kurzrock
SJR Q1FWCI 1.7Molecular Cancer TherapeuticsOA

Molecular profiling of circulating tumor DNA (ctDNA) is a promising noninvasive tool. Here, next-generation sequencing (NGS) of blood-derived ctDNA was performed in patients with advanced colorectal cancer. We investigated ctDNA-derived genomic alterations, including potential actionability, concordance with tissue NGS, and serial dynamics in 78 patients with colorectal cancer using a clinical-grade NGS assay that detects single nucleotide variants (54-73 genes) and selected copy-number variants

Cancer ResearchBiochemistry, Genetics and Molecular Biology
7
논문|인용수 24·2002
Phase II Study of Chemotherapy with ACNU Plus Cisplatin Followed by Cranial Irradiation in Patients with Newly Diagnosed Glioblastoma Multiforme
In Sil Choi, Se‐Hoon Lee, Tae‐You Kim, Jae Seug Bang, Sun Ha Paek, Suzy Kim, Il Han Kim, Dae Seog Heo, Yung‐Jue Bang, Dong Gyu Kim, Hee‐Won Jung, Noe Kyeong Kim
SJR Q1FWCI 0.8Journal of Neuro-Oncology
GeneticsMedicine
8
논문|인용수 17·2010
Biomarker analysis in patients with advanced gastric cancer treated with S-1 plus cisplatin chemotherapy: orotate phosphoribosyltransferase expression is associated with treatment outcomes
In Sil Choi, Hye Seung Lee, Keun-Wook Lee, Haeryoung Kim, Ki Hwan Kim, Yu Jung Kim, Jee Hyun Kim, Woo Ho Kim, Jong Seok Lee
SJR Q1FWCI 1.0Medical Oncology
Pulmonary and Respiratory MedicineMedicine
9
논문|인용수 15·2004
Adult patients with t(8;21) acute myeloid leukemia had no superior treatment outcome to those without t(8;21): a single institution?s experience
In Sil Choi, Eun Youn Roh, Dae‐Young Kim, Keun‐Wook Lee, Tak Yun, Dong Soon Lee, Sung‐Soo Yoon, Seonyang Park, Byoung Kook Kim, Noe Kyeong Kim
SJR Q2FWCI 0.8Annals of Hematology
HematologyMedicine
10
논문|인용수 12·2018
A population-based outcomes study of patients with metastatic gastric cancer receiving second-line chemotherapy: A nationwide health insurance database study
In Sil Choi, Jee Hyun Kim, Ju Hyun Lee, Koung Jin Suh, Ji Yun Lee, Jiwon Kim, Se Hyun Kim, Jin Won Kim, Jeong‐Ok Lee, Yu Jung Kim, Soo‐Mee Bang, Jong Seok Lee
SJR Q1FWCI 1.5PLoS ONEOA

The findings provide a better understanding of second-line treatment patterns and outcomes in patients with MGC and will help guide treatment decisions in real-world clinical practice.

Pulmonary and Respiratory MedicineMedicine
11
논문|인용수 9·2020
The 21-Gene Recurrence Score Assay and Prediction of Chemotherapy Benefit: A Propensity Score-Matched Analysis of the SEER Database
In Sil Choi, Jiwoong Jung, Byoung Hyuck Kim, Sohee Oh, Jong-Jin Kim, Jin Hyun Park, Jeong Hwan Park, Ki‐Tae Hwang
SJR Q1FWCI 0.6CancersOA

Our findings provide real-world evidence that the 21-gene RS assay is predictive of chemotherapy benefit among patients in clinical practice. More refined risk estimates would be needed for patients with an intermediate RS.

Cancer ResearchBiochemistry, Genetics and Molecular Biology
12
논문|인용수 9·2011
Leukopenia in Patients with Iron Deficiency Anemia
Yoojoo Lim, Eun Young Lee, In Sil Choi, Tae Yong Kim, Sung‐Soo Yoon, Ki Hwan Kim
SJR Q1Blood

Abstract Abstract 5279 Background: There is a lack of clinical research regarding the effect of iron deficiency anemia on white blood cells (WBC).This study presents the incidence of leukopenia in patients with iron deficiency anemia and the relationship between the white blood cell count and the level of hemoglobin(Hb). Patients and Method: Medical records of patients over 12 years of age with iron deficiency anemia were reviewed. Patients with concomitant disease that may alter the WBC count s

OncologyMedicine
13
논문|인용수 8·1988
Production of charged Higgs particles in the two-photon process at e-p scattering (HERA)
In Sil Choi, B.H. CHO, B.R. Kim, R. Rodenberg
SJR Q1FWCI 2.6Physics Letters B
Nuclear and High Energy PhysicsPhysics and Astronomy
14
논문|인용수 7·1990
Photon polarization in B→<mml:math xmlns:mml="http://www.w3.org/1998/Math/MathML" display="inline"><mml:mrow><mml:msup><mml:mrow><mml:mi>K</mml:mi></mml:mrow><mml:mrow><mml:mo>/</mml:mo><mml:mi>e</mml:mi><mml:mi>m</mml:mi><mml:mi>p</mml:mi><mml:mi>h</mml:mi><mml:mo>&gt;</mml:mo><mml:mn/><mml:mo>γ</mml:mo></mml:mrow></mml:msup></mml:mrow></mml:math>
In Sil Choi, S. Choi, H. S. Song
FWCI 0.6Physical review. D. Particles, fields, gravitation, and cosmology/Physical review. D. Particles and fields

The polarization of the outgoing photon in the decay process B\ensuremath{\rightarrow}${K}^{\mathbf{*}}$\ensuremath{\gamma} followed by the decay process ${K}^{\mathbf{*}}$\ensuremath{\rightarrow}K\ensuremath{\pi} is considered and it is shown that information on form factors in the B decay can be obtained through the photon polarization.

Nuclear and High Energy PhysicsPhysics and Astronomy
15
논문|인용수 6·2023
A Phase 3 Randomized Clinical Trial to Compare Efficacy and Safety between Combination Therapy and Monotherapy in Elderly Patients with Advanced Gastric Cancer (KCSG ST13-10)
Keun‐Wook Lee, Dae Young Zang, Min‐Hee Ryu, Hye Sook Han, Ki Hyang Kim, Mi‐Jung Kim, Sung Ae Koh, Sung Sook Lee, Dong‐Hoe Koo, Yoon Ho Ko, Byeong Seok Sohn, Jin Won Kim
SJR Q1FWCI 1.6Cancer Research and TreatmentOA

Combination therapy was associated with numerically improved OS, although statistically insignificant, and a significant PFS benefit compared with monotherapy. Although combination therapy showed more frequent TRAEs, there was no difference in the frequency of severe TRAEs.

Pulmonary and Respiratory MedicineMedicine

대표 연구 분야

OncologyCancer ResearchPulmonary and Respiratory MedicineSurgeryPathology and Forensic MedicineEpidemiology

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