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이재협 교수

Jae Hyup Lee

서울대학교 · 의학

연구실 소개

이재협 교수의 연구실은 척추 외과에서의 생체재료 및 임상적 응용을 중심으로 한 혁신적 연구를 수행하고 있습니다. 특히 척추 임플란트의 생체적합성 향상과 뼈 재생 촉진을 위한 생체세라믹스, PEEK 소재의 하이드로우레이트 코ating 기술 개발에 주력하고 있으며, 골다공리아 환자 대상 척추 후방유합술의 안정성과 생체역학적 성능 향상에 기여하고자 합니다. 또한, 자연 뼈의 구성 원리를 모방한 생체모방 세라믹스 개발을 통해 보다 효과적인 뼈 재생 재료를 개발하고 있습니다.

생체세라믹스PEEK 코ating뼈 재생척추 임플란트생체모방 재료

연구 현황

논문 수
306
총 인용 수
4,841
최근 5년 논문
46
주요 분야
의학

연구 성과 추이

표시된 성과는 수집된 데이터 기준으로 산출되며, 일부 차이가 있을 수 있습니다.

5개년 연도별 논문 게재 수
46총합
2021
2022
2023
2024
2025
5개년 연도별 피인용 수
515총합
20212022202320242025

주요 논문

15
1
논문|인용수 215·2012
In vitro and in vivo evaluation of the bioactivity of hydroxyapatite-coated polyetheretherketone biocomposites created by cold spray technology
Jae Hyup Lee, Hae Lin Jang, Kyung Mee Lee, Hae-Ri Baek, Kyoungsuk Jin, Kug Sun Hong, Jun Hong Noh, Hyun-Kyung Lee
SJR Q1FWCI 5.6Acta Biomaterialia
Biomedical EngineeringEngineering
2
논문|인용수 183·2015
The Correlation Between Cage Subsidence, Bone Mineral Density, and Clinical Results in Posterior Lumbar Interbody Fusion
Kyu Won Oh, Jae Hyup Lee, Ji Ho Lee, Do-Yoon Lee, Hee Jong Shim
SJR Q1FWCI 3.5Clinical Spine Surgery A Spine Publication

This study revealed that cage subsidence is relevant to BMD. However, it was demonstrated that subsidence is not related to the clinical deterioration. Therefore, PLIF procedure which is conducted carefully can be a good surgical option to treat lumbar degenerative disease for osteoporotic patients.

Pathology and Forensic MedicineMedicine
3
논문|인용수 150·2020
Green New Deal Policy of South Korea: Policy Innovation for a Sustainability Transition
Jae-Hyup Lee, Jisuk Woo
SJR Q1FWCI 8.8SustainabilityOA

This paper explores the recently announced “Green New Deal” policy of South Korea as a sustainability transition strategy. Originally proposed as a post-COVID-19 stimulus plan, the Green New Deal is a sustainability-centered strategy for building a low-carbon and climate-neutral economy. The Green New Deal sets out eight targets to be accomplished under three strategic areas: green urban development, low-carbon decentralized energy, and innovative green industry. The Deal also takes measures to

Global and Planetary ChangeEnvironmental Science
4
논문|인용수 133·2015
In Vitro and In Vivo Evaluation of Whitlockite Biocompatibility: Comparative Study with Hydroxyapatite and <i>β</i>‐Tricalcium Phosphate
Hae Lin Jang, Guang Bin Zheng, Jungha Park, Hwan Kim, Hae‐Ri Baek, Hye Kyoung Lee, Keunho Lee, Heung Nam Han, Choon‐Ki Lee, Nathaniel S. Hwang, Jae Hyup Lee, Ki Tae Nam
SJR Q1FWCI 4.2Advanced Healthcare Materials

Biomimicking ceramics have been developed to induce efficient recovery of damaged hard tissues. Among them, calcium phosphate-based bioceramics have been the most widely used because of their similar composition with human hard tissue and excellent biocompatibilities. However, the incomplete understanding of entire inorganic phases in natural bone has limited the recreation of complete bone compositions. In this work, broad biomedical evaluation of whitlockite (WH: Ca18Mg2(HPO4)2(PO4)12), which

Biomedical EngineeringEngineering
5
논문|인용수 83·2010
Fusion Rates and Subsidence of Morselized Local Bone Grafted in Titanium Cages in Posterior Lumbar Interbody Fusion Using Quantitative Three-Dimensional Computed Tomography Scans
Jae Hyup Lee, Do-Whan Jeon, Suk-Jae Lee, Bong‐Soon Chang, Choon‐Ki Lee
SJR Q1FWCI 2.6Spine

The ratio of fused area of local bone inside cages at regions exposed to endplates was <50%, which is insufficient for physiologic load transmission. The authors recommend that additional bone should be grafted into the disc space or new bone bonding interbody spacer should be considered.

Pathology and Forensic MedicineMedicine
6
논문|인용수 64·2015
Cold-spray coating of hydroxyapatite on a three-dimensional polyetheretherketone implant and its biocompatibility evaluated by<i>in vitro</i>and<i>in vivo</i>minipig model
Jae Hyup Lee, Hae Lin Jang, Kyung Mee Lee, Hae-Ri Baek, Kyoungsuk Jin, Jun Hong Noh
SJR Q2FWCI 2.0Journal of Biomedical Materials Research Part B Applied Biomaterials

PEEK is a bioinert material that does not chemically bind to native bone tissue and thus formation of natural bone-like hydroxyapatite (HA) coating layer on PEEK has been an important challenge to improve biocompatibility and to preserve mechanical property of PEEK. Among various coating techniques, cold-spray coating method is suitable to form stable HA coating layer on PEEK while maintaining their chemical properties, because it can be conducted in relatively low-temperature range. Therefore,

Biomedical EngineeringEngineering
7
논문|인용수 60·2011
The First Clinical Trial of Beta-Calcium Pyrophosphate as a Novel Bone Graft Extender in Instrumented Posterolateral Lumbar Fusion
Jae Hyup Lee, Bong‐Soon Chang, Ul-Oh Jeung, Kunwoo Park, Min‐Seok Kim, Choon‐Ki Lee
SJR Q1FWCI 3.8Clinics in Orthopedic SurgeryOA

β-CPP combined with an autograft is as effective as autologous bone for grafting during instrumented posterolateral spinal fusion. These findings suggest that β-CPP bone chips can be used as a novel bone graft extender for short-segment posterolateral spinal fusion.

Pathology and Forensic MedicineMedicine
8
논문|인용수 58·2011
Fusion rates of a morselized local bone graft in polyetheretherketone cages in posterior lumbar interbody fusion by quantitative analysis using consecutive three-dimensional computed tomography scans
Jae Hyup Lee, Jae Hyup Lee, Ji-Ho Lee, Ji-Ho Lee, Jaewoo Park, Hye Soo Lee
SJR Q1FWCI 1.6The Spine Journal
Pathology and Forensic MedicineMedicine
9
논문|인용수 55·2004
Biomechanical and histomorphometric study on the bone–screw interface of bioactive ceramic-coated titanium screws
Jae Hyup Lee, Hyun‐Seung Ryu, Dongsoo Lee, Kug Sun Hong, Bong‐Soon Chang, Choon‐Ki Lee
SJR Q1FWCI 1.2Biomaterials
Biomedical EngineeringEngineering
10
논문|인용수 49·2012
Comparative study of fusion rate induced by different dosages of Escherichia coli–derived recombinant human bone morphogenetic protein-2 using hydroxyapatite carrier
Jae Hyup Lee, Chang Hun Yu, Jae Jun Yang, Hae‐Ri Baek, Kyung-Mee Lee, Taeyoung Koo, Bong‐Soon Chang, Choon‐Ki Lee
SJR Q1FWCI 3.7The Spine Journal
Biomedical EngineeringEngineering
11
논문|인용수 48·2008
A prospective consecutive study of instrumented posterolateral lumbar fusion using synthetic hydroxyapatite (Bongros®‐HA) as a bone graft extender
Jae Hyup Lee, Chang Ju Hwang, Byung‐Wook Song, Ki‐Hyung Koo, Bong‐Soon Chang, Choon‐Ki Lee
SJR Q1FWCI 1.0Journal of Biomedical Materials Research Part A

A prospective, single institution, clinical case-matched, radiographic study was undertaken. Thirty-two patients underwent posterior lumbar interbody fusion with cages containing laminectomized bone chips and posterolateral lumbar fusion with pedicle screws. Autogenous bone graft (3 mL) plus 3 mL of hydroxyapatite was placed in one side of a posterolateral gutter, and 6 mL of autogenous iliac bone graft was placed on the other side. Bony union, volumes of fusion mass, and bone absorption rates w

Pathology and Forensic MedicineMedicine
12
논문|인용수 48·2020
BMP-2 and hMSC dual delivery onto 3D printed PLA-Biogel scaffold for critical-size bone defect regeneration in rabbit tibia
Shi Huan Han, Misun Cha, Yuan Jin, Kyung-Mee Lee, Jae Hyup Lee
SJR Q2FWCI 2.5Biomedical Materials

3D printing technology has various advantages, and the incorporation of bioactive substances into the 3D printed scaffold provides the biological and architectural characteristics of the scaffolds, which is very important for obtaining a good osseointegration effect. In this relation, this study prepared a novel porous hollow cage poly(lactic acid) (PLA) 3D printed scaffold and combined recombinant human bone morphogenetic protein-2 (rhBMP-2) and/or mesenchymal stem cells (MSCs) with Biogel comp

Biomedical EngineeringEngineering
13
논문|인용수 48·2014
Comparison of radiological and clinical results of balloon kyphoplasty according to anterior height loss in the osteoporotic vertebral fracture
Jae Hyup Lee, Dong‐Oh Lee, Jiho Lee, Hyeong-Seok Lee, Ji-Ho Lee, Hyeong-Seok Lee
SJR Q1FWCI 2.1The Spine Journal
SurgeryMedicine
14
논문|인용수 47·2016
Comparison of fusion rate and clinical results between CaO-SiO2-P2O5-B2O3 bioactive glass ceramics spacer with titanium cages in posterior lumbar interbody fusion
Jae Hyup Lee, Chang-Bae Kong, Jae Jun Yang, Hee-Jong Shim, Ki Hyoung Koo, Jeehyoung Kim, Choon‐Ki Lee, Bong‐Soon Chang
SJR Q1FWCI 1.0The Spine Journal
Pathology and Forensic MedicineMedicine
15
논문|인용수 43·2011
Bioactive ceramic coating of cancellous screws improves the osseointegration in the cancellous bone
Jae Hyup Lee, Hwa Kyung Nam, Bong‐Soon Chang, Choon‐Ki Lee, Hyun‐Seung Ryu, Jun-Hyuk Seo
SJR Q2FWCI 2.8Journal of Orthopaedic Science
Biomedical EngineeringEngineering

대표 연구 분야

Biomedical EngineeringSurgeryPathology and Forensic MedicineLawOrthopedics and Sports MedicineOphthalmology

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