최재혁 교수

A number of pathogenic species of basidiomycete fungi are either life-threatening pathogens of humans or major economic pests for crop production. Sensing the host is a key aspect of pathogen proliferation during disease, and signal transduction pathways are critically important for detecting environmental conditions and facilitating adaptation. This review focuses on the contributions of the cAMP/protein kinase A (PKA) signaling pathway in Cryptococcus neoformans, a species that causes meningit

Agrobacterium tumefaciens-mediated transformation (ATMT) has become a prevalent tool for functional genomics of fungi, but our understanding of T-DNA integration into the fungal genome remains limited relative to that in plants. Using a model plant-pathogenic fungus, Magnaporthe oryzae, here we report the most comprehensive analysis of T-DNA integration events in fungi and the development of an informatics infrastructure, termed a T-DNA analysis platform (TAP). We identified a total of 1110 T-DN

Outbreaks of rice blast have been a threat to the global production of rice. Members of the Magnaporthe grisea species complex cause blast disease on a wide range of gramineous hosts, including cultivated rice and other grass species. Recently, based on phylogenetic analyses and mating tests, isolates from crabgrass were separated from the species complex and named M. grisea. Then other isolates from grasses including rice were named as M. oryzae. Here, we collected 103 isolates from 11 differen

Cyclic AMP-dependent protein kinase A (PKA) regulates elaboration of the virulence factors melanin and polysaccharide capsule in Cryptococcus neoformans. A mutation in PKA1 encoding the catalytic subunit is known to reduce virulence in mice while a defect in PKR1 encoding the regulatory subunit enhances disease. Here, we constructed strains with galactose-inducible and glucose-repressible versions of PKA1 and PKR1 by inserting the GAL7 promoter upstream of the genes. As expected, no capsule was

Rice blast fungus, Magnaporthe oryzae, is the most destructive pathogen in the rice-growing area. This fungus has a biotrophic phase early in infection and later switches to a necrotrophic lifestyle. During the biotrophic phase, the fungus competes with its host for nutrients and oxygen. Continuous uptake of oxygen is essential for successful establishment of blast disease of this pathogen. Here, we report transcriptional responses of the fungus to oxygen limitation. Transcriptome analysis using

한국 역사 속 과학탐방은 1998년부터 개발, 시행되고 있다. 한국 역사 속 과학 탐방의 효과에 대해서는 일부 논의가 있었으나, 실질적인 연구는 부족하였다. 이 연구에서는 한국 역사 속 과학탐방의 목적을 문화재에 대한 과학적 안목 형성 관점에서 화성 과학탐방의 사례와 함께 논의하였다. 문화재의 과학적 우수성 평가 준거를 고려하여 연구자의 안내된 질문과 수렴적 및 발산적 과학 탐구로 구성된 화성(華城) 과학 탐방 자료가 개발되고 지도 방략이 구안되었다. 본 연구에서는 문화재의 과학적 우수성 평가 준거를 고려한 화성 과학 탐방을 지도하여 중학생들이 문화재의 과학적 우수성을 올바로 평가할 수 있는 분별 능력, 즉 문화재에 대한 과학적 안목을 형성하는지 여부를 조사 하고자 하였다. 서울 지역 중학교 과학 특별활동반 10명을 연구 대상으로 하였다. 탐방 전과 후에 실시된 '문화재의 과학적 우수성 평가하기' 설문과 탐방 후 면담을 통해 탐방을 통한 관점 변화를 분석하여 과학 탐방 활동으로 문화

Nitrogen (N) is a macronutrient important for the survival of plants. To investigate the effects of N deficiency, a time-course metabolic profiling of radish sprouts was performed. A total of 81 metabolites-including organic acids, inorganic acid, amino acids, sugars, sugar alcohols, amines, amide, sugar phosphates, policosanols, tocopherols, phytosterols, carotenoids, chlorophylls, and glucosinolates-were characterized. Principal component analysis and heat map showed distinction between sample

In June 2020, brown spot symptoms were observed in a commercial potato field located in Yeocheon, Gyeonggi Province, Korea. The symptoms were similar to those associated with early blight. Brown lesions on leaves were circular and expanded rapidly under high humidity and warm temperatures ranging 12°C at night to 30°C during daytime. Over 60% of potato (Solanum tuberosum L. cv. Superior) leaves showed the symptoms. For fungal isolation, infected leaf tissues (5 × 5 mm) from 14 infected samples w

The monokaryotic strain, <i>Schizophyllum commune</i> strain IUM1114-SS01, was generated from a basidiospore of dikaryotic parental strain IUM1114. It even showed the decolorizing activities for several textile dyes much better than its parental strain. Based on the results of a single-molecule real-time sequencing technology, we present the draft genome of <i>S. commune</i> IUM1114-SS01, comprising 41.1 Mb with GC contents of the genome were 57.44%. Among 13,380 protein-coding genes, 534 genes

Species in the genus <i>Trametes</i> (<i>Basidiomycota, Polyporales</i>) have been used in natural medicine for a long time. Many studies reported that mycelia or fruiting bodies of <i>Trametes</i> spp. exhibited effects of antioxidant, anti-inflammatory, anticancer, and antimicrobial activities. However, comparative analysis in this genus is scarce due to limitation of morphological identification and the sample number. In this study, the 19 strains of seven <i>Trametes</i> species were chosen

Synthetic dyes are widely used in various industries and their wastage causes severe environmental problems while being hazardous to human health, leading to the need for eco-friendly degradation techniques. The split-gill fungus <i>Schizophyllum commune</i>, which is found worldwide, has the potential to degrade all components of the lignocellulosic biomass and is a candidate for the treatment of synthetic dyes. A systematic molecular analysis of 75 Korean and 6 foreign <i>S. commune</i> strain

This study investigated eating behaviors of high school students (209 males and 230 females) in Daegu region by gender. As a result of analyzing breakfast intake frequency, ‘Not rarely eat’ showed the highest (25.1%), followed by ‘5 times a week’ (24.4%), ‘2 times a week’ (17.3%), ‘3 times a week’ (15.0%), ‘1 time a week’ (11.6%), and ‘4 times a week’ (6.6%). Regarding reasons for skipping breakfast, ‘lack of time’ showed the highest percentages. For their breakfast, 53.5% of students ate boiled

In the article by Choi et al. (2007) an error appeared in Fig. 1. The corrected figure is shown below.

Rice blast fungus, Magnaporthe oryzae, inflicts serious damage to global rice production. Due to high variability of this fungal pathogen, resistance of newly-released rice cultivars is easily broken down. To understand the population structure of M. oryzae, we analyzed the genetic diversity of the Korean population using multilocus microsatellite typing. Eleven microsatellite markers were applied to the population of 190 rice isolates which had been collected in Korea for two decades since the