전상학 교수

Phosphatidylserine (PS) is an integral component of eukaryotic cell membranes and organelles. The <i>Drosophila</i> genome contains a single PS synthase (PSS)-encoding gene (<i>Pss</i>) homologous to mammalian PSSs. Flies with <i>Pss</i> loss-of-function alleles show a reduced life span, increased bang sensitivity, locomotor defects, and vacuolated brain, which are the signs associated with neurodegeneration. We observed defective mitochondria in mutant adult brain, as well as elevated productio

Biological sciences have been dramatically changed since the discovery of DNA structure and now biological engineering is expected to be a key industrial area in the twenty-first century. Among several biological areas, "reproduction and development" become more interesting as they are directly related to the maintenance of human beings and recent technological success on these areas. Cloned animals produced by nuclear transplantation and artificial insemination are such cases. In this paper, it

Maintenance of appropriate muscle mass is crucial for physical activity and metabolism. Aging and various pathological conditions can cause sarcopenia, a condition characterized by muscle mass decline. Although sarcopenia has been actively studied, the mechanisms underlying muscle atrophy are not well understood. Thus, we aimed to investigate the role of Phosphatidylserine synthase (Pss) in muscle development and homeostasis in Drosophila. The results showed that muscle-specific Pss knockdown de

The ventral nerve cord (VNC) of Drosophila exhibits significant segmental-specific characteristics during embryonic development. Homeotic genes are expressed over long periods of time and confer identity to the different segments. castor (cas) is one of the genes which are expressed in neuroblasts along the VNC. However, at late embryonic stages, cas transcripts are found only in head and thoracic segments and terminal abdominal segments, while Cas protein lasts longer in all segments. In this s

Nervous system development takes place after positional information has been established along the dorsal-ventral (D/V) axis. The initial subdivision provided by a gradient of nuclear dorsal protein is maintained by the zygotic genes expressed along the D/V axis. In this study, an investigation was conducted to determine the range of Dpp function in repressing the expression of eagle (eg) that is present in intermediate neuroblasts defective (ind) and muscle specific homeobox (msh) gene domain.

Different proliferation of neuroblast 6-4 (NB6-4) in the thorax and abdomen produces segmental specific expression pattern of several neuroblast marker genes. NB6-4 is divided to form four medialmost cell body glia (MM-CBG) per segment in thorax and two MM-CBG per segment in abdomen. As homeotic genes determine the identities of embryonic segments along theA/P axis, we investigated if temporal and specific expression of homeotic genes affects MM-CBG patterns in thorax and abdomen. A Ubx loss-of-

This study examines the growth of an innovative pre-service science teachers’ (PST) community over a period of three years in a voluntary and informal setting for teaching science to high school students. The objective of this study is to understand the traits and conditions necessary for the learning and development that occurred in the PST group. We describe the growth of the PST group with a focus on the group’s endeavor to move from simple laboratory work to a more inquiry-based approach to

Glial cells play essential roles in the nervous system. Although glial populations are tightly regulated, the mechanisms regulating the population size remain poorly understood. Since Drosophila glial cells are similar to the human counterparts in their functions and shapes, rendering them an excellent model system to understand the human glia biology. Lipid phosphate phosphatases (LPPs) are important for regulating bioactive lipids. In Drosophila, there are three known LPP-encoding genes: wunen

초파리에서 호메오틱 유전자의 발현 유지에 관여하는 것으로 알려진 extra sex caribs (eso)유전자 돌연변이가 중배엽에서 Ultrabithorax (Ubx)유전자의 발현에 미치는 영향을 조사하였다. 동형의 esc 돌연변이는 배아에서 치사적이며 초파리의 초기 발현에 영향을 주지 않기 때문에 모게 영향을 나타내는 돌연변이 을 선택하여 Ubx repnrter초파리와 재 조합시켰다. Ubx는 정상의 초파리에서는 parasegment 7에서 발현되지만, esc 모계영향 돌연변이에서는 매우 적은 수의 배아에서 전위적 (ectopic) 인 발현이 관찰되었으며, 대부분의 배아에서는 발현이 억제되는 것이 관찰되었다. 이러한 억제 현상은 Ubx보다 뒤쪽에서 발현되는 abdomina]-A (abd-A)와 Abdominal-B (Abd-B)유전자가 Ubx가 발현되는 지역에서 또한 발현되어 Ubx의 발현을 억제하는 것으로 생각되며, 전위적인 발현을 보이는 것은 개체마다 모계 영향이 차이가 있어