손지훈 교수

ObjectiveaaThe aim of this study was to estimate the prevalence and correlates of mental disorders in Korean adults. MethodsaaDoor to door household surveys were conducted with community residents aged 18–74 years from July 19, 2011, to November 16, 2011 (n=6,022, response rate 78.7%). The sample was drawn from 12 catchment areas using a multistage cluster method. Each subject was assessed using the Korean version of the World Health Organization Composite International Diagnostic Interview (CID

Alzheimer's disease (AD) is the fastest growing neurodegenerative disease in the elderly population, and the search for therapeutic targets and diagnostic AD biomarkers is an exigent issue. Because amyloid-β (Aβ) aggregation constitutes the epicenter of AD pathology, Aβ-binding proteins that regulate Aβ aggregation, such as transthyretin (TTR), have attracted much attention. TTR binds to Aβ, prevents its aggregation, and consequently inhibits Aβ-induced cellular toxicity. Decreased TTR levels in

The (Ba0.5Sr0.5)TiO3 (BST) thin films were deposited on the LaNiO3/Pt(111)/Ti/SiO2/Si [LNO/Pt(111)] and LaNiO3/Pt(200)/SiO2/Si [LNO/Pt(200)] substrates by metalorganic deposition process. The BST films directly grown on the Pt(200) and Pt(111) substrates exhibited random orientation. In case of the LNO/Pt(111) substrates, the BST film was also randomly oriented, but the insertion of LNO interlayer on the Pt(200) substrates caused the growth of (100) textured BST films. The dielectric constant of

With a rapidly aging society, geriatric mental health is emerging as important public health concern. Despite the short history of psychiatric epidemiology in Korea, recently,epidemiologic data regarding geriatric psychiatric problems has started to accumulate. In the current study, we reviewed epidemiological findings regarding geriatric mental health in Korea. It was found that up to 10% of the elderly suffer from dementia, and 10% to 20% from depressive disorder. Further, prevalence estimates

Objective The 12-item General Health Questionnaire (GHQ-12) has been used extensively in various settings across different cultures. This study was conducted to determine the thresholds associated with optimum sensitivity and specificity for the GHQ-12 in Korean adults. Methods Data was acquired from a sample of 6,510 Korean adults, ages 18 to 64 years old, who were selected from the 2005 Census (2,581 men and 3,929 women). Participants completed the GHQ-12 and the Korean Composite International

Alzheimer's disease (AD) is characterized by two major neurological features: amyloid deposits and neurofibrillary tangles in the brain. According to the amyloid cascade hypothesis, accumulation of amyloid-beta peptide (A-beta) plays a central role in the pathogenesis of AD. Several lines of evidence suggest that antibodies against A-beta play a protective role in the neuropathology of AD. In this study, we describe the purification of an autoantibody against A-beta from human serum using affini

We identified barriers to maternal and child healthcare and coping strategies among African refugee mothers in Korea. Future research should assess refugees' health status and improve health access and literacy among refugee mothers.

DSM-IV가 제시하는 주요우울장애 진단 기준은 한국인의 우울증을 평가하는 데 있어 타당하기는 하나, 진단 기준의 역치가 높다. 우울증의 중증도에 따라 호소하는 증상들이 달랐다.

Personality traits, especially extraversion, and neuroticism, may be useful for predicting the mental health outcomes of LTE in older adults. Further longitudinal studies investigating the relationship between traumatic events and mental health outcomes are needed.