박지웅 교수
Ji Ung Park
서울대학교 · 의학
연구실 소개
박지웅 교수의 연구실은 만성 상처 치유와 피부 재생을 핵심 목표로 하며, 특히 당뇨병성 발저림(DFU)의 병태생리적 환경에서 미생물군집의 역할과 피부 미생물과의 상호작용을 분석하고 있습니다. 또한 생체재료 기반의 상처 피복재(예: 케이터산-실리카 하이브리드 막)와 혈관성 신경성 줄기세포를 활용한 피부질환 치료 전략을 개발하고 있습니다. 최근에는 고온 처리를 통한 생체재료 기반의 섬유성 낭종 형성 억제 기술과 같은 혁신적 생체재료 기술도 함께 연구하고 있습니다.
연구 현황
연구 성과 추이
표시된 성과는 수집된 데이터 기준으로 산출되며, 일부 차이가 있을 수 있습니다.
주요 논문
15Diabetic foot ulcer (DFU) is a complication experienced by diabetic patients and does not heal well in an altered wound environment. Although diverse microbes in DFU were detected, little is known about their influences on diabetic foot wound (DFW) and the association with the skin microbiota in normal tissue from the same patients according to clinical features. We aimed to analyze the microbiota in normal skin and DFW tissue from the same subject and predict their roles based on clinical featu
Abstract In this article, a triple‐band folded dipole antenna consists of modified planar dual‐element folded dipoles and a monopole for global positioning system (GPS)/digital communication system (DCS)/wireless local area network (WLAN)/worldwide interoperability for microwave access (WiMAX) applications is proposed. The triple‐band operation is enabled by applying a bilateral symmetric structure and coupling by adding stubs to the wideband antenna. The antenna passbands are satisfying the typ
This article presents the efficacy of heat-induced MPC-grafting against excessive fibrous capsule formation and related inflammation in tissues surrounding silicone breast implants inserted in a pig model.
In this study, we evaluated the surface characterization of a novel chitosan-silica hybridized membrane and highlighted the substantial role of silica in the wound environment. The chemical coupling of chitosan and silica resulted in a more condensed network compared with pure chitosan, which was eventually able to stably maintain its framework, particularly in the wet state. In addition, we closely observed the wound-healing process along with the surface interaction between chitosan-silica and
FU hair transplantation could be an effective method for managing scar tissue on the scalp and offers several advantages, including a high transplantation survival rate and satisfactory postoperative results.
Commercialized dressing materials with or without silver have played a passive role in early-phase wound healing, protecting the skin defects from infections, absorbing exudate, and preventing dehydration. Chitosan (CTS)-based sponges have been developed in pure or hybrid forms for accelerating wound healing, but their wound-healing capabilities have not been extensively compared with widely used commercial dressing materials, providing limited information in a practical aspect. In this study, w
Abstract There is an unmet need in novel therapeutics for atopic dermatitis ( AD ). We examined the effects of autologous adipose‐derived stem cells ( ADSC s) on AD ‐like skin lesions induced by the application of 2,4‐dinitrochlorobenzene ( DNCB ) in NC /Nga mice. Autologous ADSC s and ADSC ‐conditioned medium ( ADSC ‐ CM ) were injected intralesionally three times. Clinical severity and histopathologic findings were compared in sham naïve control, saline‐treated, ADSC ‐treated, ADSC ‐ CM ‐treat
The surface of human silicone breast implants is covalently grafted at a high density with a 2-methacryloyloxyethyl phosphorylcholine (MPC)-based polymer. Addition of cross-linkers is essential for enhancing the density and mechanical durability of the MPC graft. The MPC graft strongly inhibits not only adsorption but also the conformational deformation of fibrinogen, resulting in the exposure of a buried amino acid sequence, γ377-395, which is recognized by inflammatory cells. Furthermore, the
This study aimed to investigate the prevalence pattern of pressure injuries (PIs), or 'sores', in South Korea and investigate the factors affecting its development. We estimated the annual prevalence of PIs using the National Inpatient Sample (NIS) data extracted from the Health Insurance Review and Assessment Service (HIRA) database from 2009 to 2015. Multivariable logistic regression was performed to examine the association between hospitalization and socio-demographic characteristics, such as
Although silicone implants are widely used in breast and other reconstructive surgeries, the limited biocompatibility of these materials leads to severe complications, including capsular contracture. Here, we aimed to clarify the relationship between periostin and the process of capsule formation after in vivo implantation. Seven-week-old wild-type (WT) C57BL/6 mice and periostin-deficient mice were used. Round silicone implants were inserted into a subcutaneous pocket on the dorsum of the mice.
This paper presents guidelines for the design and optimization of on-chip coils used for wirelessly-powered mm-scale neural implants. Since available real estate is limited, on-chip coil design involves managing difficult trade-offs between the number of turns, trace width and spacing, proximity to other active circuits and metalization, quality factor, matching network performance/size, and load impedance conditions, all towards achieving high power transfer efficiency. To illustrate the design
The incidence of distant migration of a subdermal implant is possible and should be checked up regularly. If the device cannot be palpated or detected by ultrasound at the original implanting site, this should be concerned. Since the single-rod subdermal implant is radiopaque, it can be detected by roentgenography. In this case the distant migration was detected in the axilla, therefore using C arm-guided technique is feasible for the removal of the migrating device. After reviewing the literatu
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