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김지원 교수

Ji Won Kim

서울대학교 · 의학

연구실 소개

김지원 교수의 연구실은 주로 약물 유도 간손상, 장내 미생물군의 변화, 염증성 장질환의 분자 기전에 초점을 맞추고 있습니다. 특히 간 손상 생물학적 마커의 정량적 평가와 항생제에 의한 장내 미생물군의 변화에 대한 프로바이오틱스의 영향을 연구하며, Crohn병 등 염증성 장질환에서의 전사 인자 NF-κB의 역할을 규명하고자 합니다. 또한, 암세포 및 간세포를 특이적으로 인식하는 아ptoamer 개발을 통해 진단 및 치료 기반 기술을 개발하고 있습니다.

약물유도간손상장내미생물군NF-κB아ptoamer염증성장질환

연구 현황

논문 수
303
총 인용 수
3,302
최근 5년 논문
66
주요 분야
의학

연구 성과 추이

표시된 성과는 수집된 데이터 기준으로 산출되며, 일부 차이가 있을 수 있습니다.

5개년 연도별 논문 게재 수
66총합
2022
2023
2024
2025
2026
5개년 연도별 피인용 수
180총합
20222023202420252026

주요 논문

15
1
논문|인용수 167·2015
The Effect of Probiotics on Gut Microbiota during the <i>Helicobacter pylori</i> Eradication: Randomized Controlled Trial
Bumjo Oh, Bong Soo Kim, Ji Won Kim, Ji Won Kim, Jong S. Kim, Jong S. Kim, Seong‐Joon Koh, Byeong Gwan Kim, Kook Lae Lee, Jongsik Chun
SJR Q1FWCI 6.8Helicobacter

Probiotic supplementation can reduce the antibiotic-induced alteration and imbalance of the gut microbiota composition. This effect may restrict the growth of antibiotic-resistant bacteria in the gut and improve the H. pylori eradication success rate.

SurgeryMedicine
2
논문|인용수 63·2017
NF-kappa B activation correlates with disease phenotype in Crohn’s disease
Yoo Min Han, Jaemoon Koh, Ji Won Kim, Ji Won Kim, Changhyun Lee, Seong-Joon Koh, ByeongGwan Kim, Kook Lae Lee, Jong Pil Im, Joo Sung Kim, Joo Sung Kim
SJR Q1FWCI 5.7PLoS ONEOA

Crohn's disease patients with high NF-κB activation showed specific clinical manifestations of higher frequency of ileocolonic involvement and lower frequency of perianal involvement relative to those with low NF-κB activation. High NF-κB activity was associated with higher histologic scores. However, the NF-κB activity did not affect the outcome and disease course after surgery.

GeneticsBiochemistry, Genetics and Molecular Biology
3
논문|인용수 36·2009
4대 사회보험 통합 정책형성과정 분석 - ‘수정된 정책흐름모형’ 적용과 정책적 시사점 -
김지원

본 연구는 4대 사회보험 통합이슈가 몇 차례의 정책변동 시도에도 불구하고 매번 정책의제수준에서 좌절되어 정책표류 현상을 겪었던 원인을 수정된 정책흐름모형을 적용한 정책형성과정분석을 통해 추론한 것이다. 분석대상 기간은 사회보험 통합 이슈가 정책의제로 크게 부각되었던 국민의 정부 기간 내인 제1기(1998년 2월부터 2000년 10월)와 참여정부 기간 내인 제2기(2004년 11월부터 2008년 2월)로 한정한다. 질적 정책사례연구 방식을 이용한 주요 분석결과를 살펴보면 첫째, 시기별로 정책대안은 비일관성을 띠며, 정책문제 해결에 적합한지 여부와 무관하게 제시되었다는 점이다. 둘째, 민주화가 상당히 진전된 시기였음에도 공식적 참여자 주도로 정책의제화가 이루어지는 하향식 접근방법을 보여 여론의 강력한 지지를 얻기 곤란하였다. 결국, 4대 사회보험 통합 정책사례의 경우 정책결정의 지연 이유로 이슈맥락보다는 정치적 흐름과 공식적 행위주체의 정책선호 및 태도, 역량을 반영하는 정치체제맥락이

4
논문|인용수 35·2020
Toll-like receptor 4 regulates intestinal fibrosis via cytokine expression and epithelial-mesenchymal transition
Yu Kyung Jun, So Hyun Kwon, Hee Tae Yoon, Hyunsun Park, Hosim Soh, Hyun Jung Lee, Jong Pil Im, Joo Sung Kim, Ji Won Kim, Seong‐Joon Koh
SJR Q1FWCI 3.6Scientific ReportsOA

Intestinal fibrosis induced by chronic and recurrent colitis, which is exacerbated by bowel stenosis, stricture, and obstruction, is challenging to treat. Toll-like receptor 4 (TLR4) stimulates innate and acquired immunity in response to specific microbial components, but the role of TLR4 in intestinal fibrosis is largely unknown. We investigated its role in intestinal fibrosis using not only a murine fibrosis model but also human myofibroblasts and intestinal epithelial cells. Colon fibrosis wa

GeneticsBiochemistry, Genetics and Molecular Biology
5
논문|인용수 32·2022
Adverse events following COVID-19 vaccination in South Korea between February 28 and August 21, 2021: A nationwide observational study
Dong Seok Lee, Ji Won Kim, Kook Lae Lee, Yong Jin Jung, Hyoun Woo Kang
SJR Q1FWCI 3.1International Journal of Infectious DiseasesOA

Although there were differences in the frequency of occurrence, various adverse reactions were confirmed in using all 4 COVID-19 vaccines, even with the BNT162b2 (Pfizer-BioNTech) vaccine. Caution is needed, and further research should be continuously conducted.

Infectious DiseasesMedicine
6
논문|인용수 30·2013
Comparison of Clinical Outcomes between Endoscopic and Radiologic Placement of Self-expandable Metal Stent in Patients with Malignant Colorectal Obstruction
Ji Won Kim, Ji Bong Jeong, Kook Lae Lee, Byeong Gwan Kim, Yong Jin Jung, Won Kim, Hwi Young Kim, Dong‐Won Ahn, Seong‐Joon Koh, Jaekyung Lee
SJR Q3FWCI 1.3Korean Journal of GastroenterologyOA

When the colorectal obstruction had a tortuous, curved angulation of the colon or was located at or proximal to the descending colon, the endoscopic method of SEMS placement appears to be more useful than the radiologic method. However, once SEMS placement was technically successful, the clinical success rate, complication rate, and stent patency did not differ with the method of insertion.

OncologyMedicine
7
논문|인용수 29·2018
Online incivility in comment boards: Partisanship matters - But what I think matters more
Ji Won Kim
SJR Q1FWCI 3.4Computers in Human Behavior
CommunicationSocial Sciences
8
논문|인용수 27·2016
Comparable Efficacy of a 1-L PEG and Ascorbic Acid Solution Administered with Bisacodyl versus a 2-L PEG and Ascorbic Acid Solution for Colonoscopy Preparation: A Prospective, Randomized and Investigator-Blinded Trial
Jieun Kwon, Jung Won Lee, Jong Pil Im, Ji Won Kim, Ji Won Kim, Su Hwan Kim, Seong‐Joon Koh, Byeong Gwan Kim, Kook Lae Lee, Sang Gyun Kim, Joo Sung Kim, Joo Sung Kim
SJR Q1FWCI 1.9PLoS ONEOA

ClinicalTrials.gov NCT 01745835; Clinical Research Information Service (CRiS) KCT0000708.

OncologyMedicine
9
논문|인용수 27·2021
Association of obesity, visceral adiposity, and sarcopenia with an increased risk of metabolic syndrome: A retrospective study
Su Hwan Kim, Hyoun Woo Kang, Ji Bong Jeong, Dong Seok Lee, Dong‐Won Ahn, Ji Won Kim, Byeong Gwan Kim, Kook Lae Lee, Sohee Oh, Soon Ho Yoon, Sang Joon Park
SJR Q1FWCI 2.3PLoS ONEOA

Obesity, visceral adiposity, and sarcopenia showed additive effects on MS prediction. Subjects with obesity, visceral adiposity, or sarcopenia were significantly associated with the increased risk of MS after adjustment for multiple confounders. Increasing skeletal muscle and reducing visceral fat may be strategies for the prevention or treatment of MS.

PhysiologyMedicine
10
논문|인용수 25·2022
A Double-Blind, Randomized, Placebo-Controlled, Phase II Clinical Study To Evaluate the Efficacy and Safety of Camostat Mesylate (DWJ1248) in Adult Patients with Mild to Moderate COVID-19
Kim Ys, Seng‐Ho Jeon, Jung-Hee Kim, Jung-Hee Kim, Jong Hoon Koh, Seung Won, Ji Won Kim, Ji Won Kim, Yeonjae Kim, Choon Kwan Kim, Yun Chul Shin, Beodeul Kang
SJR Q1FWCI 2.5Antimicrobial Agents and ChemotherapyOA

Although several antiviral agents have become available for coronavirus disease 2019 (COVID-19) treatment, oral drugs are still limited. Camostat mesylate, an orally bioavailable serine protease inhibitor, has been used to treat chronic pancreatitis in South Korea, and it has an <i>in vitro</i> inhibitory potential against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). This study was a double-blind, randomized, placebo-controlled, multicenter, phase 2 clinical trial in mild to mod

Infectious DiseasesMedicine
11
논문|인용수 17·2015
The effect of long Roux-en-Y gastrojejunostomy in gastric cancer patients with type 2 diabetes and body mass index &amp; 35 kg/m<sup>2</sup>: preliminary results
Ji Won Kim, Kwang‐Yong Kim, Seung‐Chul Lee, Dae Hyun Yang, Byung Chun Kim
SJR Q2FWCI 1.8Annals of Surgical Treatment and ResearchOA

The effect of long RY gastrojejunostomy after gastrectomy for diabetes control could be contentious but an applicable reconstruction method for diabetes control in gastric cancer patients with type 2 diabetes and BMI < 35 kg/m(2). Diabetes remission is expected to be higher in patients with greater BMI reduction, short duration of diabetes, and lower preoperative HbA1c.

SurgeryMedicine
12
논문|인용수 17·2021
Telemedicine Surge for Pediatric Patients in Response to the COVID-19 Pandemic in New York City
Ji Won Kim, Maria Lame, Leanna R Szalay, Brian Lefchak, Bille Johnsson, Kriti Gogia, Sunday Clark, David Kessler, David Leyden, Rahul Sharma, Shari L. Platt
SJR Q1FWCI 1.4Telemedicine Journal and e-Health

<b> <i>Background:</i> </b> <i>Our objective is to describe our pediatric virtual urgent care (VUC) experience at a large urban academic medical center, in response to the COVID-19 pandemic in New York City (NYC).</i> <b> <i>Materials and Methods:</i> </b> <i>We conducted a retrospective cohort study of our pediatric VUC program of patients less than age 18 years, from March 1 to May 31, 2020. We include data on expansion of staffing, patient demographics, virtual care, and outcomes.</i> <b> <i>

OncologyMedicine
13
논문|인용수 17·2017
누가 ‘진짜 피해자’인가?: 가습기 살균제 참사에서 피해자 범주의 구성
김지원
http://iccs.snu.ac.kr/03_research/research01.htm?Item=board2&mode=view&s_t=1&Page=4&No=422

가습기 살균제 참사에서 책임해명을 둘러싼 논란은 ‘가짜’를 배제한 ‘진 짜’ 피해자의 범주를 만드는 문제로 진행되어왔다. 본고는 가습기 살균제 피해제도를 둘러싼 논란으로 표면화된 ‘진짜’ 피해자의 범주를 둘러싼 협상 과 갈등을 다루었다. 가습기 살균제 피해지원제도의 법적 근거로서 가습기 살균제로 인한 중증 폐손상이 환경성질환으로 지정된 것은 가습기 살균제 의 독성물질과 증상(피해)과의 일반적 인과관계의 공식적 승인인 동시에, 제도를 통해 피해자가 시민으로서 자신의 건강에 대한 권리를 실현하는 계기였다. 제도는 생의학적 지식에 기반한 피해 판정을 통해 피해자 범주 를 통제, 재생산했고 피해자들은 제도와 의학의 담론에 맞춰 자신의 경험 을 조정해가면서 국가와 기업과 협상하게 되었다. 가습기 살균제의 독성물 질이 인체에 미치는 영향이 과학적으로 불확실한 상황 속에서, 가습기 살 균제 참사에 대한 사회적인 대응이 의학, 제도, 배상을 통해 ‘진짜’ 피해자 를 가려내는 것에 초점이 맞춰지면서

14
논문|인용수 16·2017
Plasma ghrelin level and plasma ghrelin/obestatin ratio are related to intestinal metaplasia in elderly patients with functional dyspepsia
Su Hwan Kim, Ji Won Kim, Junsu Byun, Ji Bong Jeong, Byeong Gwan Kim, Kook Lae Lee
SJR Q1FWCI 2.5PLoS ONEOA

Patients with intestinal metaplasia, a known precursor of gastric cancer, had significantly less plasma ghrelin levels and G/O ratio than those without intestinal metaplasia.

SurgeryMedicine
15
논문|인용수 15·2018
How <i>perceptions</i> of incivility and social endorsement in online comments (Dis) encourage engagements
Ji Won Kim, Sungyong Park
SJR Q1FWCI 1.1Behaviour and Information Technology

While the powerful role of partisan identity in provoking incivility has been pointed out, relatively little attention has been directed toward incivility that also occurs among individuals who share the same partisan identity. Two experiments examined how uncivil expressions made by in-group members with aligned partisanship as well as uncivil expressions made by out-group members with opposing partisanship led to perceptual, attitudinal, and behavioural intentions. Also examined are how the ef

CommunicationSocial Sciences

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SurgeryGeneticsOncologyPulmonary and Respiratory MedicineGastroenterologyEpidemiology

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