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박지원 교수

Ji Won Park

서울대학교 · 의학

연구실 소개

박지원 교수의 연구실은 주로 산화환원 조절 메커니즘과 단백질의 글루타티온화를 중심으로 세포 신호전달 및 질병 발생 메커니즘을 규명하고 있습니다. 특히 퍼옥시레독신과 퍼옥시레독신 가족 단백질의 기능 전환, 글루타티온화가 세포 기능에 미치는 영향을 분석하며, 이는 암, 심혈관 질환 등 다양한 질병의 생물학적 기전 해독에 기여하고 있습니다. 또한, 유전자 전달 기술 및 대사체 분석을 활용한 신진대사 생물학적 마커 탐색 등 다학제적 접근을 통해 임상적 응용 가능성을 탐색하고 있습니다.

글루타티온화퍼옥시레독신산화환원 조절대사체 분석유전자 전달

연구 현황

논문 수
439
총 인용 수
12,325
최근 5년 논문
84
주요 분야
의학

연구 성과 추이

표시된 성과는 수집된 데이터 기준으로 산출되며, 일부 차이가 있을 수 있습니다.

5개년 연도별 논문 게재 수
84총합
2022
2023
2024
2025
2026
5개년 연도별 피인용 수
974총합
20222023202420252026

주요 논문

15
1
논문|인용수 324·2017
Robot-assisted Versus Laparoscopic Surgery for Rectal Cancer
Min Jung Kim, Sung Chan Park, Ji Won Park, Hee Jin Chang, Dae Yong Kim, Byung‐Ho Nam, Dae Kyung Sohn, Jae Hwan Oh
SJR Q1FWCI 10.0Annals of Surgery

Robot-assisted surgery in rectal cancer showed TME quality comparable with that of laparoscopic surgery, and it demonstrated similar postoperative morbidity, bowel function recovery, and quality of life.

OncologyMedicine
2
논문|인용수 107·2007
The usefulness of preoperative colonoscopic tattooing using a saline test injection method with prepackaged sterile India ink for localization in laparoscopic colorectal surgery
Ji Won Park, Dae Kyung Sohn, Chang Won Hong, Kyung Su Han, Dong Hyun Choi, Hee Jin Chang, Seok‐Byung Lim, Han Saem Choi, S.-Y. Jeong
SJR Q1FWCI 1.5Surgical Endoscopy
OncologyMedicine
3
논문|인용수 103·2010
Clustered Magnetite Nanocrystals Cross-Linked with PEI for Efficient siRNA Delivery
Ji Won Park, Ki Hyun Bae, Chun-Soo Kim, Tae Gwan Park
SJR Q1FWCI 2.6Biomacromolecules

Magnetofection has been utilized as a powerful tool to enhance gene transfection efficiency via magnetic field-enforced cellular transport processes. The accelerated accumulation of nucleic acid molecules by applying an external magnetic force enables the rapid and improved transduction efficiency. In this study, we developed magnetite nanocrystal clusters (PMNCs) cross-linked with polyethylenimine (PEI) to magnetically trigger intracellular delivery of small interfering RNA (siRNA). PMNCs were

Molecular BiologyBiochemistry, Genetics and Molecular Biology
4
논문|인용수 94·2021
Open versus laparoscopic surgery for mid or low rectal cancer after neoadjuvant chemoradiotherapy (COREAN trial): 10-year follow-up of an open-label, non-inferiority, randomised controlled trial
Ji Won Park, Sung‐Bum Kang, Jie Hao, Seok‐Byung Lim, Hyo Seong Choi, Duck-Woo Kim, Hee Jin Chang, Dae Yong Kim, Kyung Hae Jung, Tae‐You Kim, Gyeong Hoon Kang, Eui Kyu Chie
SJR Q1FWCI 6.7˜The œLancet. Gastroenterology & hepatology
OncologyMedicine
5
논문|인용수 88·2008
Carcinoembryonic Antigen as a Predictor of Pathologic Response and a Prognostic Factor in Locally Advanced Rectal Cancer Patients Treated With Preoperative Chemoradiotherapy and Surgery
Ji Won Park, Seok‐Byung Lim, Dae Yong Kim, Kyung Hae Jung, Yong Sang Hong, Hee Jin Chang, Hyo Seong Choi, Seung‐Yong Jeong
SJR Q1FWCI 1.8International Journal of Radiation Oncology*Biology*Physics
OncologyMedicine
6
논문|인용수 86·2009
The impact of obesity on outcomes of laparoscopic surgery for colorectal cancer in Asians
Ji Won Park, Sangwoo Lim, Hyo Seong Choi, Seung‐Yong Jeong, Jae Hwan Oh, Seok‐Byung Lim
SJR Q1FWCI 1.9Surgical Endoscopy
OncologyMedicine
7
논문|인용수 82·2013
Effect of Blood Nitrite and Nitrate Levels on Murine Platelet Function
Ji Won Park, Barbora Piknova, Paul L. Huang, Constance Tom Noguchi, Alan N. Schechter
SJR Q1FWCI 6.5PLoS ONEOA

Nitric oxide (NO) appears to play an important role in the regulation of thrombosis and hemostasis by inhibiting platelet function. The discovery of NO generation by reduction of nitrite (NO₂⁻) and nitrate (NO₃⁻) in mammals has led to increased attention to these anions with respect to potential beneficial effects in cardiovascular diseases. We have previously shown that nitrite anions at 0.1 µM inhibit aggregation and activation of human platelet preparations in vitro in the presence of red blo

PhysiologyMedicine
8
논문|인용수 78·2020
The relationships between systemic cytokine profiles and inflammatory markers in colorectal cancer and the prognostic significance of these parameters
Ji Won Park, Hee Jin Chang, Hyun Yang Yeo, Nayoung Han, Byung Chang Kim, Sun‐Young Kong, Jeongseon Kim, Jae Hwan Oh
SJR Q1FWCI 3.6British Journal of CancerOA

Systemic cytokine profiles and inflammatory markers have relatively weak intergroup correlations. A composite classification of systemic cytokine profiles and inflammatory markers has an enhanced prognostic value in CRC.

OncologyMedicine
9
논문|인용수 75·2012
Silver nanoparticles modify VEGF signaling pathway and mucus hypersecretion in allergic airway inflammation
Ji Won Park, Jang, Cha, Jung, JE Lee, Jung, Ju Ock Kim, Soo Y. Kim, Lee, Hee Sun Park
SJR Q1FWCI 4.0International Journal of NanomedicineOA

The anti-inflammatory action of silver nanoparticles (NPs) has been reported in a murine model of asthma in a previous study. But more specific mechanisms of silver NPs in an attenuation of allergic airway inflammation have not yet been established. Vascular and mucous changes are believed to contribute largely in pathophysiology in asthma. Among various factors related to vascular changes, vascular endothelial growth factor (VEGF) plays a pivotal role in vascular changes in asthma. Mucin protei

PhysiologyMedicine
10
논문|인용수 64·2009
Prognostic Values of α-fetoprotein and Protein Induced by Vitamin K Absence or Antagonist-II in Hepatitis B Virus-related Hepatocellular Carcinoma
Hyoung Su Kim, Ji Won Park, Jisun Jang, Ha Jung Kim, Woon Geon Shin, Kyung Ho Kim, Jin Heon Lee, Hak Yang Kim, Myoung Kuk Jang
SJR Q2FWCI 2.4Journal of Clinical Gastroenterology

Serum PIVKA-II level, not serum AFP, was a valuable independent prognostic factor in HBV-related HCC.

HepatologyMedicine
11
논문|인용수 50·2014
How to interpret the bile culture results of patients with biliary tract infections
Ji Won Park, Jong Kyun Lee, Kyu Taek Lee, Kwang Hyuk Lee, Young Kyung Sung, Cheol‐In Kang
SJR Q2FWCI 1.7Clinics and Research in Hepatology and Gastroenterology
Pulmonary and Respiratory MedicineMedicine
12
논문|인용수 46·2010
Early Intrapulmonary Recurrence After Pulmonary Metastasectomy Related to Colorectal Cancer
Mi Ri Hwang, Ji Won Park, Dae Yong Kim, Hee Jin Chang, Sun Young Kim, Hyo Seong Choi, Moon Soo Kim, Jae Ill Zo, Jae Hwan Oh
SJR Q1FWCI 2.0The Annals of Thoracic Surgery
OncologyMedicine
13
논문|인용수 41·2007
Epidermal growth factor (EGF) receptor targeted delivery of PEGylated adenovirus
Ji Won Park, Hyejung Mok, Tae Gwan Park
SJR Q2FWCI 2.9Biochemical and Biophysical Research Communications
GeneticsBiochemistry, Genetics and Molecular Biology
14
논문|인용수 38·2009
Physical adsorption of PEG grafted and blocked poly-l-lysine copolymers on adenovirus surface for enhanced gene transduction
Ji Won Park, Hyejung Mok, Tae Gwan Park
SJR Q1FWCI 3.3Journal of Controlled Release
GeneticsBiochemistry, Genetics and Molecular Biology
15
논문|인용수 32·2014
The Mediolateral CoP Parameters can Differentiate the Fallers among the Community-dwelling Elderly Population
Ji Won Park, Mi Sook Jung, Migyoung Kweon
FWCI 9.7Journal of Physical Therapy ScienceOA

[Purpose] Age-related mediolateral (ML) instability of static postural control in the elderly has been well studied. Recent studies have provided evidence that ML center of pressure (CoP) parameters during dynamic postural control are more sensitive for differentiation of the fallers in the elderly. However, very limited studies have been done in which ML stability differences between fallers and non-fallers were investigated. The purpose of this study was to investigate the differences in ML Co

Physical Therapy, Sports Therapy and RehabilitationHealth Professions

대표 연구 분야

OncologySurgeryPhysiologyMolecular BiologyPulmonary and Respiratory MedicinePathology and Forensic Medicine

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