최지혜 교수

Emerging evidence suggests that the mammalian target of rapamcyin (mTOR) pathway is associated with radio-resistance in cancer treatment. We hypothesised that phosphorylated ribosomal S6 kinase 1 (p-S6K1), a major downstream regulator of the mTOR pathway, may play a role in predicting radio-resistance. Therefore, we evaluated the association of p-S6K1 expression with radio-resistance in breast cancer cell lines and patients. During median follow-up of 33 (range, 0.1-111) months for 1770 primary

Nanoscale electrokinetic phenomenon called ion concentration polarization (ICP) has opened a new era in bio- and chemical-analysis platform due to its high efficiency and easy sample handling. In this review, the most recent advancements of selective preconcentration process using ICP were introduced. The flux balances of charged analytes were theoretically analyzed so that the behavior and the shape of preconcentrated plug were categorized into stacking/propagating and dumbbell/plug, respective

A true diaphragmatic hernia is a congenital diaphragmatic malformation that can appear identical to a peritoneopericardial diaphragmatic hernia (PPDH). True diaphragmatic hernias are rare in dogs. Herein we describe the use of positive contrast peritoneography for diagnosis of a true diaphragmatic hernia in two dogs.

The purpose of this study was to explore the advanced utterances of students with different learning approaches and levels of scientific knowledge during small-group argumentation. It was also investigated how these advanced utterances accompanied social support to contribute to group argumentation in the science classroom. Four students were selected for the focus group and participated in the lessons designed for group argumentation about blood circulation. The following data were analyzed: tr

pS6K1 expression may predict AI therapy outcomes and serve as a potential predictive marker for adjuvant endocrine therapy in postmenopausal and ovarian function-suppressed patients with hormone-sensitive breast cancer. AIs may be more effective in patients with pS6K1 positive tumors, while SERM could be considered an alternative option for patients with pS6K1 negative tumors.

Our study provides insights into genetic susceptibility and NGRFs for predicting breast cancer in Korean women.

본 연구는 친환경 제품에 대한 소비자의 지불의사 금액을 추정하고자 하였다. 특히 친환경 제품이 타인에게 보여지는 정도, 즉 공개성 유무에 따라 친환경 제품에 대한 소비자의 지불의사 금액이 달라지는 지 확인하였다. 서울과 경기권역에 거주중인 20,30대 남녀를 대상으로 가상가치측정법 중 이중양분형설계를 사용하여 설문조사를 실시하였다. SPIKE모델을 통해 지불의사금액을 추정한 결과 친환경 제품에 대한 소비자 평균 지불의사금액은 16823.59원으로 준거 가격대비 프리미엄은 68.23%로 조사되었다. 다음으로 친환경 제품의 공개성을 조작하기 위해 공적 제품으로 가방을 사적 제품으로 정리박스를 선정하여 소비자의 지불의사 금액을 조사하였다. 공적 제품에 대한 소비자의 지불의사금액은 18937.32원, 사적 제품에 대한 소비자의 지불의사금액은 13376.47 원으로 나타났다. 각각 준거 가격 대비 프리미엄은 89.3%, 33.7%로, 공적 제품이 사적 제품에 비해 프리미엄이 높다는 것을 알

Endocrine test data from a 13-year old intact female Maltese was indicative of the presence of an insulinoma, however ultrasonography identified a pancreatic mass only after 10 months after the first admission. Following identification of both pancreatic tumor and hepatic metastasis on computed tomography (CT), surgical excision of the mass was attempted. However, total excision failed because of tumor adhesion to adjacent large vessels. The pancreatic mass was monitored over the next 25 months

This study aims to compare the effectiveness of three magnetic resonance angiography (MRA) sequences-Time-of-Flight (TOF), Phase-Contrast (PC), and Time-Resolved Imaging of Contrast Kinetics (TRICKS)-in visualizing cerebral arteries and veins in dogs. The goal is to determine the most suitable MRA sequence for improving diagnostic accuracy in canine cerebral imaging. Five healthy adult beagles underwent imaging using a 1.5-T MRI system. Quantitative measures, including signal-to-noise ratio (SNR

Objective: This study aimed to analyze the changes and predictive factors of mothers’ parenting competencies during their children’s second to third grades in primary school. Methods: We used the data from the Panel study of Korean Parental Educational Involvement. We classified 373 mothers into three groups, ‘reduced’ parenting competency, ‘maintained’ parenting competency, and ‘increased’ parenting competency, and conducted one-way variance analysis and multinomial logistic regression analysis

<p>The absolute risk of developing breast cancer was estimated using data from 20,434 Korean women. The absolute risk of breast cancer was estimated by PRS38_ASN+PRS190_EB for women in different percentiles and age categories. The dotted lines represent the average risks. (A) Lifetime absolute risk (B) 5-year absolute risk</p>

<p>Beta weights and number of breast cancer associated SNPs used to construct single PRS</p>

<p>Relative risk and population distribution of NGRFs for breast cancer in Korean women</p>