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이정렬 교수

Jung Ryeol Lee

서울대학교 · 의학

연구실 소개

이정렬 교수의 연구실은 난소 조직의 동결보존 및 이식을 통한 생식력 보존 기술 개발에 초점을 맞추고 있습니다. 특히, 고처리도 동결보존 솔루션에 포함되는 항결빙단백질(AFPs)과 혈관형성 인자(VEGF, Ang-2)의 활용을 통해 이식 후 조직 손상과 허혈성 손상을 최소화하는 데 주력하고 있으며, 이는 난소 기능 유지와 생식력 회복에 기여합니다. 또한, 난소 호르몬인 AMH의 변화와 난소 자극 반응 예측 가능성에 대한 기초 연구도 병행하고 있습니다.

생식력 보존난소 조직 동결보존혈관형성 인자항결빙단백질이식 후 손상 최소화

연구 현황

논문 수
461
총 인용 수
3,854
최근 5년 논문
59
주요 분야
의학

연구 성과 추이

표시된 성과는 수집된 데이터 기준으로 산출되며, 일부 차이가 있을 수 있습니다.

5개년 연도별 논문 게재 수
59총합
2021
2022
2023
2024
2025
5개년 연도별 피인용 수
377총합
20212022202320242025

주요 논문

15
1
논문|인용수 65·2015
Effects of antifreeze proteins on the vitrification of mouse oocytes: comparison of three different antifreeze proteins
Hyang Heun Lee, Hee Jun Lee, Hak Jun Kim, Jun Hyuck Lee, Yong Ko, Sun Mie Kim, Jung Ryeol Lee, Chang Suk Suh, Seok Hyun Kim
SJR Q1FWCI 4.3Human ReproductionOA

This study was supported by a grant of the Korea Healthcare technology R&D Project, Ministry of Health & Welfare, Republic of Korea (HI12C0055). The authors have no conflict of interest to declare.

Public Health, Environmental and Occupational HealthMedicine
2
논문|인용수 60·2015
Effects of Three Different Types of Antifreeze Proteins on Mouse Ovarian Tissue Cryopreservation and Transplantation
Jaewang Lee, Jaewang Lee, Seul Ki Kim, Hye Won Youm, Hak Jun Kim, Jung Ryeol Lee, Jung Ryeol Lee, Chang Suk Suh, Seok Hyun Kim
SJR Q1FWCI 7.6PLoS ONEOA

A supplementation with high concentrations of AFPs had protective effects on follicle preservation during OT vitrification-warming procedures. The group treated with LeIBP was protected most effectively. The beneficial effects of LeIBP were also observed after autotransplantation of vitrified-warmed OT. Further studies are necessary to determine the exact mechanism of these protective effects.

Public Health, Environmental and Occupational HealthMedicine
3
논문|인용수 51·2010
Anti-Mullerian hormone dynamics during controlled ovarian hyperstimulation and optimal timing of measurement for outcome prediction
Jung Ryeol Lee, Sang Hyuck Kim, Sun Moon Kim, B. C. Jee, Seung‐Yup Ku, Chang Suk Suh, Y. M. Choi, J. G. Kim, So Young Moon
SJR Q1FWCI 4.9Human ReproductionOA

The results of the present study suggest that changes in the hormonal milieu during stimulation and after the LH surge may affect AMH secretion. Serum AMH levels during COH are good markers to predict ovarian response, but the baseline serum level seems to be the most predictive marker.

Reproductive MedicineMedicine
4
논문|인용수 46·2011
Conventional Linear versus Purse-string Skin Closure after Loop Ileostomy Reversal: Comparison of Wound Infection Rates and Operative Outcomes
Jung Ryeol Lee, Young Wan Kim, Jong Je Sung, Ok-Pyung Song, Hyung Chul Kım, Cheol-Wan Lim, Gyu-Seok Cho, Jun Chul Jung, Eung-Jin Shin
FWCI 1.5Journal of the Korean society of coloproctologyOA

Based on this study, purse-string skin closure after a loop ileostomy reversal showed comparable outcomes, in terms of wound infection rates, to those of linear skin closure. Thus, purse-string skin closure could be a good alternative to the conventional linear closure.

OncologyMedicine
5
논문|인용수 43·2015
Effect of Antifreeze Protein on Mouse Ovarian Tissue Cryopreservation and Transplantation
Jung Ryeol Lee, Hye Won Youm, Hee Jun Lee, Byung Chul Jee, Chang Suk Suh, Seok Hyun Kim
SJR Q2FWCI 4.0Yonsei Medical JournalOA

The results of the present study suggest that supplementing AFP in the vitrification solution has beneficial effects on the survival of ovarian tissue during cryopreservation and transplantation.

Public Health, Environmental and Occupational HealthMedicine
6
논문|인용수 42·2019
The new biocompatible material for mouse ovarian follicle development in three-dimensional in vitro culture systems
Eun Jung Kim, Chungmo Yang, Jaewang Lee, Jaewang Lee, Hye Won Youm, Jung Ryeol Lee, Jung Ryeol Lee, Chang Suk Suh, Seok Hyun Kim
SJR Q1FWCI 3.8Theriogenology
Public Health, Environmental and Occupational HealthMedicine
7
논문|인용수 39·2020
Oocyte cryopreservation for fertility preservation in women with ovarian endometriosis
Se Jeong Kim, Seul Ki Kim, Jung Ryeol Lee, Chang Suk Suh, Seok Hyun Kim
SJR Q1FWCI 5.4Reproductive BioMedicine Online
Reproductive MedicineMedicine
8
논문|인용수 37·2008
Follicular fluid anti-Müllerian hormone and inhibin B concentrations: comparison between gonadotropin-releasing hormone (GnRH) agonist and GnRH antagonist cycles
Jung Ryeol Lee, Seok Hyun Kim, Sun Mie Kim, Byung Chul Jee, Seung‐Yup Ku, Chang Suk Suh, Young Min Choi, Jung Gu Kim, Shin Yong Moon
SJR Q1FWCI 6.2Fertility and Sterility
Reproductive MedicineMedicine
9
논문|인용수 36·2017
Effect of treatment with angiopoietin-2 and vascular endothelial growth factor on the quality of xenografted bovine ovarian tissue in mice
Hyun Sun Kong, Jaewang Lee, Jaewang Lee, Hye Won Youm, Seul Ki Kim, Jung Ryeol Lee, Jung Ryeol Lee, Chang Suk Suh, Seok Hyun Kim
SJR Q1FWCI 2.0PLoS ONEOA

Cryopreservation and transplantation of ovarian tissue (OT) represents a method for fertility preservation. However, as the transplantation is performed without vessel anastomosis, unavoidable ischemic damage occurs. To reduce this ischemic damage and improve outcomes after transplantation, we used two kind of angiogenic factors, angiopoietin-2 (ang-2) and vascular endothelial growth factor (VEGF). Fresh or vitrified-warmed bovine OTs were prepared for xenotransplantation (XT). Fresh OTs were im

Public Health, Environmental and Occupational HealthMedicine
10
논문|인용수 35·2017
Advantages of Single-Port Laparoscopic Myomectomy Compared with Conventional Laparoscopic Myomectomy: A Randomized Controlled Study
Dayong Lee, Seul Ki Kim, Kidong Kim, Jung Ryeol Lee, Chang Suk Suh, Seok Hyun Kim
SJR Q2FWCI 2.9Journal of Minimally Invasive Gynecology
Obstetrics and GynecologyMedicine
11
논문|인용수 35·2015
Learning Curve Analysis and Surgical Outcomes of Single-port Laparoscopic Myomectomy
Hee Jun Lee, Ju-Yeong Kim, Seul Ki Kim, Jung Ryeol Lee, Chang Suk Suh, Seok Hyun Kim
SJR Q2FWCI 3.0Journal of Minimally Invasive Gynecology
SurgeryMedicine
12
논문|인용수 27·1976
EFFECTS OF MORPHINE ON BRAIN HISTAMINE, ANTINOCICEPTION AND ACTIVITY IN MICE
Jung Ryeol Lee, M. R. Fennessy
SJR Q2FWCI 0.8Clinical and Experimental Pharmacology and Physiology

1. The effect of morphine on the histamine content of the mouse brain has been investigated. The changes in the brain histamine level have been related to morphine-induced analgesia and morphine-induced changes in locomotor activity. 2. With doses of morphine between 1 and 5 mg/kg there was a significant increase in histamine levels. The time required to produce a maximal rise in the brain histamine level with 5 mg/kg of morphine was 15 min. 3. There was a significant decrease in brain histamine

ImmunologyImmunology and Microbiology
13
논문|인용수 25·2017
Comparison of Follicle Isolation Methods for Mouse Ovarian Follicle Culture In Vitro
Eun Jung Kim, Jaewang Lee, Hye Won Youm, Seul Ki Kim, Jung Ryeol Lee, Chang Suk Suh, Seok Hyun Kim
SJR Q1FWCI 1.0Reproductive Sciences
Public Health, Environmental and Occupational HealthMedicine
14
리뷰|인용수 23·2019
A systematic review and meta-analysis comparing single port laparoscopic myomectomy with conventional laparoscopic myomectomy
Dayong Lee, Jung Ryeol Lee, Chang Suk Suh, Seok Hyun Kim
SJR Q2FWCI 2.2European Journal of Obstetrics & Gynecology and Reproductive Biology
Obstetrics and GynecologyMedicine
15
논문|인용수 23·2008
Pregnancy Outcomes of Different Methods for Multifetal Pregnancy Reduction: A Comparative Study
Jung Ryeol Lee, Seung‐Yup Ku, Byung Chul Jee, Chang Suk Suh, Ki Chul Kim, Seok Hyun Kim
SJR Q2FWCI 1.4Journal of Korean Medical ScienceOA

The purpose of this study was to evaluate the outcomes of various methods of multifetal pregnancy reduction (MFPR) and to determine which method produces better outcomes. One hundred and forty-eight patients with multiple pregnancies resulting from assisted reproduction programs and underwent MFPR were included. According to the use of potassium chloride (KCl), patients were divided into 'KCl', and 'non- KCl' groups, and based on gestational age at the time of procedures, patients were divided i

Pediatrics, Perinatology and Child HealthMedicine

대표 연구 분야

Aerospace EngineeringPublic Health, Environmental and Occupational HealthReproductive MedicineObstetrics and GynecologySurgeryPediatrics, Perinatology and Child Health

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